生体再生歯工学分野
分野の紹介
当分野では、臨床歯科医療の現場で未解決の課題に着目し、生体再生医工学の視点からその解決を図る研究に取り組んでいます。これまで、チタンナノ表面改質技術や細胞内レドックス制御技術を応用し、インプラント周囲における骨・歯周組織の再生および炎症制御を可能とする革新的バイオマテリアルの開発を進めてきました。特に、生体模倣チタンナノ表面を用いて、細胞分化の誘導や免疫応答の制御を実現し、インプラント周囲に歯周組織を選択的に誘導する新技術（Bioimplant）や、インプラント周囲炎を予防する先進的な表面改質技術の確立を目指しています。
さらに、細胞が受容する力学的刺激に注目し、咬合・咀嚼力が誘発する病態メカニズムの解明に向けたメカノバイオロジー研究を推進しています。また、AIや計算機工学と融合した次世代型歯科医療機器や教育支援システムの開発にも積極的に取り組み、医歯工学の学際的連携を実践していきます。
臨床ニーズに根ざした研究と、革新的技術の社会還元を両立させることで、再生歯科医療の新たな地平を切り拓きます。
教員構成
教授：山田 将博
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主な研究テーマ
- 咬合・咀嚼力が関与する病態の解明 力学刺激が引き起こす細胞応答と病態変化をメカノバイオロジーの視点から解析し、個別化歯科治療の基盤構築を目指します。
- 生体模倣ナノバイオマテリアルによる再生医療と病態制御 ナノ構造を活用した材料設計により、標的組織再生と炎症制御を両立する次世代型バイオマテリアルを開発します。
- ナノテクノロジーを応用した診断デバイスの開発 微小な生体反応を高感度に検出し、疾患の早期診断と予後予測を可能とする口腔内診断デバイスおよび生体機能チップを創製します。
- 細胞内レドックス制御を基盤とした組織再生と疾患制御 酸化還元バランスの調節により細胞機能を制御し、再生誘導や炎症抑制を可能とする分子メカニズムの解明と応用を進めます。
- 再生歯科医療の社会実装に向けた研究開発 知的財産の権利化、企業との連携、製品開発を通じて、基礎研究の臨床応用と社会実装を加速させます。
最近の業績
- Ogumi, Kippei, Yamada, Masahiro, Otake, Koki, Ohtake, Takayuki, Watanabe, Jun, Egusa, Hiroshi: Anisotropic three-dimensional titanium nanospike architectures drive matrix mineralization of human cementoblast-like cells through biophysical cues. Dental Materials, in press.
- Tiskratok, Watcharaphol, Yamada, Masahiro, Kyawsoewin, Maythwe, Lwin, Hnin Yu, Egusa, Hiroshi, Jitprasertwong, Paiboon, Limraksasin, Phoonsuk: Substrate stiffness modulates human gingival fibroblast paracrine signaling to promote osteogenic differentiation of human periodontal ligament cells. Frontiers in Bioengineering and Biotechnology, 14: 2026.
- Tiskratok, Watcharaphol, Kyawsoewin, Maythwe, Thuephut, Rachadol, Ketkrathok, Kansuda, Leerahakanch, Chichaya, Chanwises, Patipan, Jitprasertwong, Paiboon, Yamada, Masahiro, Egusa, Hiroshi, Limraksasin, Phoonsuk: Matrix stiffness drives aggressive phenotype in tongue squamous cell carcinoma via mechanotransduction-stromal signalling. International Dental Journal, 76: 2026.
- Yamada, Masahiro: Prosthodontic research in the big data era. Journal of Prosthodontic Research, 70: 2026.
- Hsiao, Mingyuan, Kimura, Tsuyoshi, Suzuki, Mika, Hashimoto, Yoshihide, Yamada, Masahiro, Kim, Yusoon, Harazono, Yousuke, Yoshitake, Hiroyuki, Terauchi, Masahiko, Kishida, Akio, Yoda, Tetsuya: Decellularized porcine pericardium supports periodontal ligament tissue regeneration and attenuates root resorption in a tooth replantation model. Dental Materials Journal, 45: 2026.
- Fushimi, Kunihiro, Yamada, Masahiro, Watanabe, Jun, Washio, Jumpei, Takahashi, Nobuhiro, Egusa, Hiroshi: Moderate heating of waterline improves dental unit water quality by activating bactericidal properties of tap water. Journal of Dental Sciences, 21: 2026.
- Fushimi, Kunihiro, Watanabe, Jun, Yamada, Masahiro, Washio, Jumpei, Takahashi, Nobuhiro, Egusa, Hiroshi: Effects of flushing of dental waterlines in portable dental units on water quality management. Journal of Dental Sciences, 19: 2024.
- Kato, Eiji, Yamada, Masahiro, Kokubu, Eitoyo, Egusa, Hiroshi, Ishihara, Kazuyuki: Anisotropic patterns of nanospikes induces anti-biofouling and mechano-bactericidal effects of titanium nanosurfaces with electrical cue. Materials Today Bio, 29: 2024.
- He, Xindie, Yamada, Masahiro, Watanabe, Jun, Qu, Pengyu, Chen, Jiang, Egusa, Hiroshi: Titanium nanotopography enhances mechano-response of osteocyte three-dimensional network toward osteoblast activation. Biomaterials Advances, 163: 2024.
- Kondo, Takeru, Yamada, Masahiro, Egusa, Hiroshi: Innate immune regulation in dental implant osseointegration. Journal of Prosthodontic Research, 68(4): 2024.
- Tiskratok, Watcharaphol, Yamada, Masahiro, Watanabe, Jun, Pengyu, Qu, Kimura, Tsuyoshi, Egusa, Hiroshi: Mechanoregulation of Osteoclastogenesis-Inducing Potentials of Fibrosarcoma Cell Line by Substrate Stiffness. International Journal of Molecular Sciences, 24(10): 2023.
- Nattasit, Praphawi, Niibe, Kunimichi, Yamada, Masahiro, Ohori-Morita, Yumi, Limraksasin, Phoonsuk, Tiskratok, Watcharaphol, Yamamoto, Masaya, Egusa, Hiroshi: Stiffness-Tunable Hydrogel-Sandwich Culture Modulates the YAP-Mediated Mechanoresponse in Induced-Pluripotent Stem Cell Embryoid Bodies and Augments Cardiomyocyte Differentiation. Macromolecular Bioscience, 23(7): 2023.
- Tiskratok, Watcharaphol, Yamada, Masahiro, Watanabe, Jun, Kartikasari, Nadia, Kimura, Tsuyoshi, Egusa, Hiroshi: Substrate stiffness controls proinflammatory responses in human gingival fibroblasts. Scientific Reports, 13(1): 2023.
- He, Xindie, Yamada, Masahiro, Watanabe, Jun, Tiskratok, Watcharaphol, Ishibashi, Minoru, Kitaura, Hideki, Mizoguchi, Itaru, Egusa, Hiroshi: Titanium nanotopography induces osteocyte lacunar-canalicular networks to strengthen osseointegration. Acta Biomaterialia, 151: 2022.
- Kartikasari, Nadia, Yamada, Masahiro, Watanabe, Jun, Tiskratok, Watcharaphol, He, Xindie, Egusa, Hiroshi: Titania nanospikes activate macrophage phagocytosis by ligand-independent contact stimulation. Scientific Reports, 12(1): 2022.
- Zhang, Maolin, Niibe, Kunimichi, Kondo, Takeru, Limraksasin, Phoonsuk, Okawa, Hiroko, Miao, Xinchao, Kamano, Yuya, Yamada, Masahiro, Jiang, Xinquan, Egusa, Hiroshi: Rapid and efficient generation of cartilage pellets from mouse induced pluripotent stem cells by transcriptional activation of BMP-4 with shaking culture. Journal of Tissue Engineering, 13: 2022.
- Yamada, Masahiro, Kimura, Tsuyoshi, Nakamura, Naoko, Watanabe, Jun, Kartikasari, Nadia, He, Xindie, Tiskratok, Watcharaphol, Yoshioka, Hayato, Shinno, Hidenori, Egusa, Hiroshi: Titanium Nanosurface with a Biomimetic Physical Microenvironment to Induce Endogenous Regeneration of the Periodontium. Acs Applied Materials & Interfaces, 14(24): 2022.
- Ohori-Morita, Yumi, Niibe, Kunimichi, Limraksasin, Phoonsuk, Nattasit, Praphawi, Miao, Xinchao, Yamada, Masahiro, Mabuchi, Yo, Matsuzaki, Yumi, Egusa, Hiroshi: Novel Mesenchymal Stem Cell Spheroids with Enhanced Stem Cell Characteristics and Bone Regeneration Ability. Stem Cells Translational Medicine, 11(4): 2022.
- Kartikasari, Nadia, Yamada, Masahiro, Watanabe, Jun, Tiskratok, Watcharaphol, He, Xindie, Kamano, Yuya, Egusa, Hiroshi: Titanium surface with nanospikes tunes macrophage polarization to produce inhibitory factors for osteoclastogenesis through nanotopographic cues. Acta Biomaterialia, 137: 2021.
- Limraksasin, Phoonsuk, Kosaka, Yukihiro, Zhang, Maolin, Horie, Naohiro, Kondo, Takeru, Okawa, Hiroko, Yamada, Masahiro, Egusa, Hiroshi: Shaking culture enhances chondrogenic differentiation of mouse induced pluripotent stem cell constructs. Scientific Reports, 10(1): 2020.
- Yamada, Masahiro, Watanabe, Jun, Ueno, Takeshi, Ogawa, Takahiro, Egusa, Hiroshi: Cytoprotective Preconditioning of Osteoblast-Like Cells with N-Acetyl-L-Cysteine for Bone Regeneration in Cell Therapy. International Journal of Molecular Sciences, 20(20): 2019.
- Watanabe, Jun, Yamada, Masahiro, Niibe, Kunimichi, Zhang, Maolin, Kondo, Takeru, Ishibashi, Minoru, Egusa, Hiroshi: Preconditioning of bone marrow-derived mesenchymal stem cells with N-acetyl-L-cysteine enhances bone regeneration via reinforced resistance to oxidative stress. Biomaterials, 185: 2018.
- Yamada, Masahiro, Egusa, Hiroshi: Current bone substitutes for implant dentistry. Journal of Prosthodontic Research, 62(2): 2018.
分野問い合わせ
山田 将博 E-mail：yamamasa*tohoku.ac.jp（*を＠に変えてください。）