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先端再生医学研究センター

センターの紹介

先端再生医学研究センターは，最先端の再生医学の取り組みから次世代の再生歯科医療を実現・先導するための研究組織として2015年4月に歯学研究科に設置されました。

当センターは，「再生医学研究ユニット」と「再生医療推進ユニット」からなり，再生医療に関する基礎研究から，これを臨床の形にするトランスレーショナルリサーチまで，各ステージの技術開発を推進しています。メンバーはさまざまな基礎・臨床分野の専門家で構成され，既存の歯学概念や枠組にとらわれない独創的で分野融合的な研究を目指します。

センター長　教授：江草　宏

センターの構成

再生医学研究ユニット

  • 星川聖良（小児発達歯科学分野　医員）
  • 千葉満生（小児発達歯科学分野　医員）

再生医療推進ユニット

  • 齋藤正寛（歯科保存学分野　教授）
  • 鈴木　治（顎口腔機能創建学分野　教授）
  • 江草　宏（分子・再生歯科補綴学分野　教授）

主な研究テーマ

  • 歯周組織再生医療に用いるヒト脂肪幹細胞製剤調整技術の開発
  • iPS細胞/間葉系幹細胞を基盤とする口腔組織再生技術の開発
  • 乳歯歯髄幹細胞を用いた病態解明・新規治療法の開発
  • リン酸オクタカルシウム（OCP）を用いた骨再生技術の開発
  • 骨再生分子メカニズムの解明と骨再生医療への応用
  • 口腔癌発症分子機序を基盤とした幹細胞分化制御機構の探索

最近の業績

  1. Watahiki A, Hoshikawa S, Chiba M, Egusa H, Fukumoto S, Inuzuka H: Deficiency of lipin2 results in enhanced proinflammatory response and osteoclast formation in macrophages. Int J Mol Sci, 22(6): 2893, 2021.
  2. Limraksasin P, Okawa H, Zhang M, Kondo T, Osathanon T, Pavasant P, Egusa H: Size-optimized micro-space culture facilitates differentiation of mouse induced pluripotent stem cells into osteoid-rich bone constructs. Stem Cells Int, 7082679, 2020.
  3. Sato N, Handa K, Venkataiah VS, Hasegawa T, Njuguna MM, Yahata Y, Saito M: Comparison of the vertical bone defect healing abilities of carbonate apatite, β-tricalcium phosphate, hydroxyapatite and bovine-derived heterogeneous bone. Dent Mater J. 39(2):309-318. 2020.
  4. Baba K, Shiwaku Y, Hamai R, Mori Y, Anada T, Tsuchiya K, Oizumi I, Miyatake N, Itoi E, Suzuki O. Chemical stability-sensitive osteoconductive performance of octacalcium phosphate bone substitute in an ovariectomized rat tibia defect. ACS Appl Bio Mater 3(3): 1444-1458, 2020.
  5. Suzuki O, Shiwaku Y, Hamai R. Octacalcium phosphate bone substitute materials: Comparison between properties of biomaterials and other calcium phosphate materials. Dent Mater J 39(2): 187-199, 2020.
  6. Kawai T, Kamakura S, Matsui K, Fukuda M, Takano H, Iino M, Ishikawa S, Kawana H, Soma T, Imamura E, Kizu H ,Michibata A, Asahisa I, Miura K, Nakamura N, Kibe T, Suzuki O, Takahashi T. Clinical study of octacalcium phosphate and collagen composite in oral and maxillofacial surgery. J Tissue Eng. 11: 1-15, 2020.
  7. Venkataiah VS, Handa K, Njuguna MM, Hasegawa T, Maruyama K, Nemoto E, Yamada S, Sugawara S, Lu L, Takedachi M, Murakami S, Okura H, Matsuyama A, Saito M: Periodontal Regeneration by Allogeneic Transplantation of Adipose Tissue Derived Multi-Lineage Progenitor Stem Cells in vivo. Sci Rep. 9(1):921, 2019.
  8. Watahiki A, Shimizu K, Hoshikawa S, Chiba M, Kitamura H, Egusa H, Fukumoto S, Inuzuka H: Lipin-2 degradation elicits a proinflammatory gene signature in macrophages. Lipin-2 degradation elicits a proinflammatory gene signature in macrophages. Biochem Biophys Res Commun, 524(2):477-483, 2020.
  9. Limraksasin P, Kondo T, Zhang M, Okawa H, Osathanon T, Pavasant P, Egusa H: In Vitro Fabrication of Hybrid Bone/Cartilage Complex Using Mouse Induced Pluripotent Stem Cells. Int J Mol Sci, 21(2), 2020.
  10. Ma Y, Cui D, Xiong X, Inuzuka H, Wei W, Sun Y, North BJ, Zhao Y: SCFβ-TrCP ubiquitinates CHK1 in an AMPK-dependent manner in response to glucose deprivation. Mol Oncol, 13(2):307-321, 2019.
  11. Yamada M, Watanabe J, Ueno T, Ogawa T, Egusa H: Cytoprotective Preconditioning of Osteoblast-Like Cells with N-Acetyl-L-Cysteine for Bone Regeneration in Cell Therapy. Int J Mol Sci, 20(20), 2019.
  12. Suzuki O. Evolution of octacalcium phosphate biomaterials. In Chapter 1, Octacalcium Phosphate Biomaterials, pp.1-15. Edits: O Suzuki, G Insley. Woodhead Publishing Series in Biomaterials, Elsevier. 2019.
  13. Sato T, Anada T, Hamai R, Shiwaku Y, Tsuchiya K, Sakai S, Baba K, Sasaki K, Suzuki O. Culture of hybrid spheroids composed of calcium phosphate materials and mesencymal stem cells on an oxygen-permeable culture device to predict in vivo bone forming capability. Acta Biomater 88: 477-490, 2019.
  14. Kurobane K, Shiwaku Y, Anada T, Hamai R, Tsuchiya K, Baba K, Iikubo M, Takahashi T, Suzuki O. Angiogenesis involvement by octacalcium phosphate-gelatin composite-driven bone regeneration in rat calvaria critical-sized defect. Acta Biomater 88: 514-526, 2019.
  15. Shiwaku Y, Tsuchiya K, Xiao L, Suzuki O. Effect of calcium phosphate phases affecting the cosstalk between osteoblasts and osteoclast in vitro. J Biomed Mater Res A 107(5): 1001-1013, 2019.
  16. Watanabe J, Yamada M, Niibe K, Zhang M, Kondo T, Ishibashi M, Egusa H: Preconditioning of bone marrow-derived mesenchymal stem cells with N-acetyl-L-cysteine enhances bone regeneration via reinforced resistance to oxidative stress. Biomaterials, 185:25-38, 2018.
  17. Huang LY, Zhao J, Chen H, Wan L, Inuzuka H, Guo J, Fu X, Zhai Y, Lu Z, Wang X, Han ZG, Sun Y, Wei W: SCFFBW7-mediated degradation of Brg1 suppresses gastric cancer metastasis. Nat Commun, 9(1):3569, 2018.
  18. Ci Y, Li X, Chen M, Zhong J, North BJ, Inuzuka H, He X, Li Y, Guo J, Dai X: SCFβ-TRCP E3 ubiquitin ligase targets the tumor suppressor ZNRF3 for ubiquitination and degradation. Protein Cell, 9(10):879-889, 2018.
  19. Shimizu K, Nihira NT, Inuzuka H, Wei W: Physiological functions of FBW7 in cancer and metabolism. Cell Signal, 46:15-22, 2018.
  20. Sai Y, Shiwaku Y, Anada T, Tsuchiya K, Takahashi T, Suzuki O. Capacity of octacalcium phosphate to promote osteoblastic differentiation toward osteocytes in vitro. Acta Biomater 69:362-371, 2018.
  21. Iwamatsu-Kobayashi Y, Abe S, Fujieda Y, Orimoto A, Kanehira M, Handa K, Venkataiah VS, Zou W, Ishikawa M, Saito M: Metal ions from S-PRG filler have the potential to prevent periodontal disease. Clin Exp Dent Res, 3(4):126-133, 2017.
  22. Niibe K, Zhang M, Nakazawa K, Morikawa S, Nakagawa T, Matsuzaki Y, Egusa H: The potential of enriched mesenchymal stem cells with neural crest cell phenotypes as a cell source for regenerative dentistry. Jpn Dent Sci Rev, 53(2):25-33, 2017.
  23. Nihira NT, Ogura K, Shimizu K, North BJ, Zhang J, Gao D, Inuzuka H, Wei W: Acetylation-dependent regulation of MDM2 E3 ligase activity dictates its oncogenic function. Sci Signal, 10(466), 2017.
  24. Masuda T, Maruyama H, Arai F, Anada T, Tsuchiya K, Fukuda T, Suzuki O. Application of an indicator-immobilized-gel-sheet for measuring the pH surrounding a calcium phosphate-based biomaterial. J Biomater Appl 31(9): 1296-1304, 2017.
  25. Okawa H, Kayashima H, Sasaki J, Miura J, Kamano Y, Kosaka Y, Imazato S, Yatani H, Matsumoto T, Egusa H. Scaffold-Free Fabrication of Osteoinductive Cellular Constructs Using Mouse Gingiva-Derived Induced Pluripotent Stem Cells. Stem Cells Int, 2016:6240794, 2016.
  26. Tadaki M, Anada T, Shiwaku Y, Nakamura T, Nakamura M, Kojima M, Arai T, Fukumoto S, Suzuki O. A 3D culture model study monitoring differentiation of dental epithelial cells into ameloblast-like cells. RSC Adv 6: 62109-62118, 2016
  27. Hirayama B, Anada T, Shiwaku Y, Miyatake N, Tsuchiya K, Nakamura M, Takahashi T, Suzuki O. Immune cell response and subsequent bone formation induced by implantation of octacalcium phosphate in a rat tibia defect RSC Adv 6: 57475-57484, 2016
  28. Kamoya T, Anada T．Shiwaku Y, Takano-Yamamoto T, Suzuki O. An oxygen-permeable spheroid culture chip (Oxy chip) promotes osteoblastic differentiation of mesenchymal stem cells. Sens Actuators: B Chem 232: 75-83, 2016
  29. Anada T, Sato T, Kamoya T, Shiwaku Y, Tsuchiya K, Takano-Yamamoto T, Sasaki K, Suzuki O. Bioactivity of octacalcium phosphate utilizing osteoblastic cell aggregates in a spheroid culture device. Regen Ther. 3: 58-62, 2016.
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