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歯内歯周治療学分野

分野の紹介

歯内歯周治療学分野は、口腔内の2大感染症の一つである歯周病、そして歯髄/象牙質複合体への感染により生じる歯内疾患(歯髄疾患および根尖性歯周組織疾患)という慢性炎症をターゲットとして、その発症・進展機構解明と歯周組織および歯髄/象牙質の再生治療法の開発を目指した研究を行っています。

歯周病を代表例として、口腔内の細菌感染とそれにより生じた炎症が全身の健康に様々な影響を及ぼすことが近年明らかにされています。当分野では、発症メカニズムとそれに基づいた診断・治療法の開発のみならず、硬・軟両方の組織からなる歯周組織と象牙質/歯髄複合体の再生についての研究を展開しており、歯学だけでなく基礎医学の国際一流誌に数多くの成果を報告しております。

歯内歯周治療学分野は東北大学病院歯科部門において歯周病科と歯内療法科を担当しており、先進医療を含む歯周病と歯内疾患の治療を行うばかりでなく数々の臨床研究・臨床治験も実施しています。口腔から全身の健康確立に寄与していく、それが私たちの目指すものです。

教員構成

主な研究テーマ

  • 歯周病ならびに根尖性歯周疾患の分子生物学的病態解析
  • 歯周病の全身的影響の分子生物学的解析
  • 歯周組織再生医学
  • 歯周病の病態診断法の開発
  • マイクロ精密加工による生体材料の開発
  • 歯髄及び歯周組織の病態生理学

最近の業績

  1. Epigenetics in susceptibility, progression, and diagnosis of periodontitis. Shigeki Suzuki, Satoru Yamada. The Japanese dental science review 58 183-192 2022.
  2. Loss of IκBζ drives dentin formation via altered H3K4me3 status H. Yuan, S. Suzuki, H. Terui, S. Hirata-Tsuchiya, E. Nemoto, K. Yamasaki, M. Saito, H. Shiba, S. Aiba, S. Yamada. Journal of Dental Research 101(8) 951-961 2022.
  3. Extracellular vesicles derived from murine cementoblasts possess the potential to increase receptor activator of Nuclear Factor-κB Ligand-induced osteoclastogenesis. Rei Sato, Kentaro Maruyama, Eiji Nemoto, Yukihiko Sakisaka, Shigeki Suzuki, Jiajun Li, Kento Numazaki, Hiroyuki Tada, Satoru Yamada. Frontiers in physiology 13 825596-825596 2022.
  4. Porphyromonas gingivalis induces entero-hepatic metabolic derangements with alteration of gut microbiota in a type 2 diabetes mouse model. Yoichiro Kashiwagi, Shunsuke Aburaya, Naoyuki Sugiyama, Yuki Narukawa, Yuta Sakamoto, Masatomo Takahashi, Hayato Uemura, Rentaro Yamashita, Shotaro Tominaga, Satoko Hayashi, Takenori Nozaki, Satoru Yamada, Yoshihiro Izumi, Atsunori Kashiwagi, Takeshi Bamba, Yasushi Ishihama, Shinya Murakami. Scientific reports 11(1) 18398-18398 2021.
  5. PPARγ-induced global H3K27 acetylation maintains osteo/cementogenic abilities of periodontal ligament fibroblasts. Hang Yuan, Shigeki Suzuki, Shizu Hirata-Tsuchiya, Akiko Sato, Eiji Nemoto, Masahiro Saito, Hideki Shiba, Satoru Yamada. International journal of molecular sciences 22(16) 2021.
  6. Mouse model of Loeys-Dietz syndrome shows elevated susceptibility to periodontitis via alterations in Transforming Growth Factor-Beta signaling. Satoru Yamada, Kenichiro Tsushima, Masaki Kinoshita, Hiromi Sakashita, Tetsuhiro Kajikawa, Chiharu Fujihara, Hang Yuan, Shigeki Suzuki, Takayuki Morisaki, Shinya Murakami. Frontiers in physiology 12 715687-715687 2021.
  7. DMP-1 promoter-associated antisense strand non-coding RNA, panRNA-DMP-1, physically associates with EGFR to repress EGF-induced squamous cell carcinoma migration. Shigeki Suzuki, Hang Yuan, Shizu Hirata-Tsuchiya, Kazuma Yoshida, Akiko Sato, Eiji Nemoto, Hideki Shiba, Satoru Yamada. Molecular and cellular biochemistry 476(4) 1673-1690 2021.
  8. Mice lacking PLAP-1/asporin counteracts high fat diet-induced metabolic disorder and alveolar bone loss by controlling adipose tissue expansion. Hiromi Sakashita, Satoru Yamada, Masaki Kinoshita, Tetsuhiro Kajikawa, Tomoaki Iwayama, Shinya Murakami. Scientific reports 11(1) 4970-4970 2021.
  9. Expression of asporin reprograms cancer cells to acquire resistance to oxidative stress. Yuto Sasaki, Kurara Takagane, Takumi Konno, Go Itoh, Sei Kuriyama, Kazuyoshi Yanagihara, Masakazu Yashiro, Satoru Yamada, Shinya Murakami, Masamitsu TanakaCancer science 112(3) 1251-1261 2021.
  10. Inhibition of the CXCL9-CXCR3 axis suppresses the progression of experimental apical periodontitis by blocking macrophage migration and activation. Tatsuya Hasegawa, V Venkata Suresh, Yoshio Yahata, Masato Nakano, Shigeto Suzuki, Shigeki Suzuki, Satoru Yamada, Hideki Kitaura, Itaru Mizoguchi, Yuichiro Noiri, Keisuke Handa, Masahiro Saito. Scientific reports 11(1) 2613-2613 2021.
  11. A large-scale observational study to investigate the current status of diabetic complications and their prevention in Japan (JDCP study 6): baseline dental and oral findings. Koji Inagaki, Takeshi Kikuchi, Toshihide Noguchi, Akio Mitani, Keiko Naruse, Tatsuaki Matsubara, Masamitsu Kawanami, Jun Negishi, Yasushi Furuichi, Eiji Nemoto, Satoru Yamada, Hiromasa Yoshie, Koichi Tabeta, Sachiyo Tomita, Atsushi Saito, Sayaka Katagiri, Yuichi Izumi, Hiroshi Nitta, Takanori Iwata, Yukihiro Numabe, Matsuo Yamamoto, Nobuo Yoshinari, Tsuyoshi Fujita, Hidemi Kurihara, Fusanori Nishimura, Toshihiko Nagata, Hiromichi Yumoto, Toru Naito, Kazuyuki Noguchi, Koichi Ito, Shinya Murakami, Rimei Nishimura, Naoko Tajima. Diabetology international 12(1) 52-61 2021.
  12. Guidelines for innovation in dental education during the coronavirus disease 2019 pandemic. Guang Hong, Tsai-Yu Chang, Andrew Terry, Supachai Chuenjitwongsa, Young-Seok Park, James K Tsoi, M F Lindawati S Kusdhany, Hiroshi Egusa, Satoru Yamada, Jae-Sung Kwon, Liang-Lin Seow, Ma Cristina A G Garcia, Mun-Loke Wong, Prim Auychai, Ming-Lun Hsu. Journal of oral science 63(1) 107-110 2020.
  13. Evaluation of preosteoblast MC3T3-E1 cells cultured on a microporous titanium membrane fabricated using a precise mechanical punching process. Jingyu Zhang, Yukihiko Sakisaka, Hiroshi Ishihata, Kentaro Maruyama, Eiji Nemoto, Shigeki Chiba, Masaru Nagamine, Hiroshi Hasegawa, Satoru Yamada. Materials (Basel, Switzerland) 13(22) 1-15 2020.
  14. A small nuclear acidic protein (MTI-II, Zn2+-binding protein, parathymosin) attenuates TNF-α inhibition of BMP-induced osteogenesis by enhancing accessibility of the Smad4-NF-κB p65 complex to Smad binding element. Hirata-Tsuchiya S, Suzuki S, Okamoto K, Saito N, Yuan H, Yamada S, Jimi E, Shiba H, Kitamura C. Molecular and Cellular Biochemistry 469(1-2) 133-142 2020.
  15. Dentin phosphoprotein inhibits lipopolysaccharide-induced macrophage activation independent of its serine/aspartic acid-rich repeats. Nakanishi J, Suzuki S, Yoshida K, Hirata-Tsuchiya S, Haruyama N, Yamada S, Shiba H. Archives of Oral Biology 110 104634-104634 2020.
  16. Mechanical regulation of macrophage function - cyclic tensile force inhibits NLRP3 inflammasome-dependent IL-1β secretion in murine macrophages. Maruyama K, Nemoto E, Yamada S. Inflammation and Regeneration 39(1) 3-3 2019.
  17. Heparin–LL37 complexes are less cytotoxic for human dental pulp cells and have undiminished antimicrobial and LPS-neutralizing abilities. Yoshida K, Suzuki S, Kawada-Matsuo M, Nakanishi J, Hirata-Tsuchiya S, Komatsuzawa H, Yamada S, Shiba H. International Endodontic Journal 52(9) 1327-1343 2019.
  18. Cyclic Stretch force induces periodontal ligament cells to secrete exosomes that Suppress IL-1β production through the inhibition of the NF-κB signaling pathway in macrophages. Wang Z, Maruyama K, Sakisaka Y, Suzuki S, Tada H, Suto M, Saito M, Yamada S, Nemoto E. Frontiers in Immunology 10 1310-1310 2019.
  19. Cyclic stretch negatively regulates IL-1β secretion through the inhibition of NLRP3 inflammasome activation by attenuating the AMP kinase pathway. Maruyama K, Sakisaka Y, Suto M, Tada H, Nakamura T, Yamada S, Nemoto E. Frontiers in Physiology 9 802 2018.

分野問い合わせ

E-mail:e-nemoto*dent.tohoku.ac.jp(*を@に変えてください。)
TEL:022-717-8336
FAX:022-717-8339

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