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歯科口腔麻酔学分野

分野の紹介

歯科口腔麻酔学分野は、麻酔臨床で生じた疑問や問題点を基礎研究で解き明かし、新たな治療法開発につながる研究を遂行しています。

・気管支痙攣/喘息・COPDの新規治療法の開発
我々は全く新たな気管性痙攣/喘息・COPDの治療法開発を目的に、新規受容体の発現探索とシグナル伝達機構の解明を進めています。本研究は15年以上にわたりColumbia大学医学部麻酔科学講座の基礎研究部門と密に連携し実施しています。

・in vivoイメージングによる口腔顔面痛発症機構の解明
定量的活動依存性マンガン造影MRIとin vivo Ca2+イメージングを併用したマルチスケールin vivo脳機能イメージング技術を用いて、口腔顔面痛発症機構の解明に取り組んでいます。

・ロボット麻酔システムの開発
工学研究科と共同で、AIを利用したclosed-loop自動麻酔システムの開発に取り組んでいます。

・制御性T細胞増強法の開発とヒスタミン産生制御機構の解明
アレルギー性疾患・自己免疫疾患の新規治療法を確立に向けて、制御性T細胞増強法の開発とヒスタミン産生制御機構の解明に取り組んでいます。

教員構成

主な研究テーマ

  • 肥満喘息誘発機序の解明
  • Gタンパク質共役型受容体を介した気管支痙攣/喘息/COPD病態修飾機構の解明
  • 口腔・腸内細菌叢による気管支喘息/COPD病態形成機構の解明
  • 口腔顔面領域における副交感神経反射性血流制御機構の解明

最近の業績

  1. Sasaki H, Zhang Y, Emala CW Sr, and Mizuta K. Melatonin MT2 receptor is expressed and potentiates contraction in human airway smooth muscle. Am J Physiol Lung Cell Mol Physiol. 321(6): L991-L1005, 2021.
  2. Hoshijima H, Higuchi H, Sato Boku A, Shibuya M, Morimoto Y, Fujisawa T, and Mizuta K. Patient satisfaction with deep versus light/moderate sedation for non-surgical procedures: A systematic review and meta-analysis. Medicine (Baltimore). 100(36): e27176, 2021.
  3. Sasaki H, Hoshijima H, Mizuta K. Ringer's acetate solution-induced precipitation of remimazolam. Br J Anaesth. 126(3): e87-e89, 2021.
  4. Bando K, Kuroishi T, Tada H, Oizumi T, Tanaka Y, Takahashi T, Mizoguchi I, Sugawara S, Endo Y. Nitrogen-containing bisphosphonates and lipopolysaccharide mutually augment inflammation via adenosine triphosphate (ATP)-mediated and interleukin 1β (IL-1β)-mediated production of neutrophil extracellular traps (NETs). J Bone Miner Res. 36(9):1866-1878, 2021.
  5. Hung LY, Tanaka Y, Herbine K, Pastore C, Singh B, Ferguson A, Vora N, Douglas B, Zullo K, Behrens EM, Li Hui Tan T, Kohanski MA, Bryce P, Lin C, Kambayashi T, Reed DR, Brown BL, Cohen NA, Herbert DR. Cellular context of IL-33 expression dictates impact on anti-helminth immunity. Sci Immunol. 5(53): eabc6259, 2021.
  6. Maekawa M, Yasuda M, Sasaki H, Tachinami Y, Mizuta K. Anesthetic management of a patient with ring 18 syndrome. Anesth Prog. 68(3): 178-179, 2021.
  7. Hoshijima H, Takeuchi R, Kikuchi K, Mizuta K. Asystole Triggered by the mouth opening with a dental mouth gag under general anesthesia during pediatric oral surgery: report of a rare case. J Oral Maxillofac Surg. 79(9):1862-1865, 2021.
  8. Hoshijima H, Mihara T, Denawa Y, Shiga T, Mizuta K. Comparison of Hemodynamic responses to administration of vasopressin and norepinephrine under general anesthesia: A systematic review and meta-analysis of randomized controlled trials with trial sequential analysis. J Cardiothorac Vasc Anesth. 35(1):61-69, 2021.
  9. Hoshijima H, Takeuchi R, Kikuchi K, Mizuta K. Anesthetic management in MAO-A and MAO-B deficiency: a case report. J Anesth. 34(5):773-776, 2020.
  10. Mizuta K, Sasaki H, Zhang Y, Matoba A, Emala CW Sr. The short-chain free fatty acid receptor FFAR3 is expressed and potentiates contraction in human airway smooth muscle. Am J Physiol Lung Cell Mol Physiol. 318(6): L1248-L1260, 2020.
  11. Mizuta K, Matoba A, Shibata S, Masaki E, Emala CW Sr. Obesity-induced asthma: Role of free fatty acid receptors. Jpn Dent Sci Rev. 55(1): 103-107, 2019.
  12. Matoba A, Matsuyama N, Shibata S, Masaki E, Emala CW, and Mizuta K. The free fatty acid receptor 1 promotes airway smooth muscle cell proliferation through MEK/ERK and PI3K/Akt signaling pathways. Am J Physiol Lung Cell Mol Physiol. 314(3): L333-L348, 2018.
  13. Matsuyama N, Shibata S, Matoba A, Kudo T, Danielsson J, Kohjitani A, Masaki E, Emala CW, and Mizuta K: The dopamine D1 receptor is expressed and induces CREB phosphorylation and MUC5AC expression in human airway epithelium. Respir Res. 19(1): 53, 2018.
  14. Hoshijima H, Mihara T, Maruyama K, Denawa Y, Mizuta K, Shiga T, and Nagasaka H. C-MAC videolaryngoscope versus Macintosh laryngoscope for tracheal intubation: a systematic review and meta-analysis with trial sequential analysis. J Clin Anesth, 49: 53-62, 2018.
  15. Hoshijima H, Takeuchi R, Mihara T, Kuratani N, Mizuta K, Wajima Z, Masaki E, and Shiga T. Weekend versus weekday admission and short-term mortality: A meta-analysis of 88 cohort studies including 56,934,649 participants. Medicine (Baltimore), 96: e6685, 2017.
  16. Masaki E, Mizuta K, Ohtani N, and Kido K.: Early postoperative nociceptive threshold and production of brain-derived neurotrophic factor induced by plantar incision are not influenced with minocycline in a rat: role of spinal microglia. Neurosignals., 24(1): 15-24, 2016.
  17. Mizuta K, Zhang Y, Mizuta F, Hoshijima H, Shiga T, Masaki E, and Emala CW. Novel identification of the free fatty acid receptor FFAR1 that promotes contraction in airway smooth muscle. Am J Physiol Lung Cell Mol Physiol, 309(9): L970-L982, 2015.
  18. Mizuta K, Zhang Y, Xu D, Mizuta F, D’Ovidio F, Masaki E, and Emala CW. The dopamine D1 receptor is expressed and facilitates relaxation in airway smooth muscle. Respir. Res. 14:89, 2013.
  19. Mizuta K, Zhang Y, Xu D, Masaki E, Panettieri RA Jr., and Emala CW. The dopamine D2 receptor is expressed and sensitizes adenylyl cyclase activity in airway smooth muscle. Am. J. Physiol. Lung Cell. Mol. Physiol., 302(3):L316-324, 2012.
  20. Kawakami S, Izumi H, Masaki E, Kuchiiwa S, and Mizuta K. Role of medullary GABA signal transduction on parasympathetic reflex vasodilatation in the lower lip. Brain Res., 1437:26-37, 2012.
  21. Izumi H, Ishii H, and Mizuta K. Anterior hypothalamic inhibition of reflex parasympathetic vasodilatation in the lower lip and palate of anaesthetized cats. Dent. J. Health., 30(2): 43-52, 2011.
  22. Mizuta K, Mizuta F, Xu D, Masaki E, Panettieri RA Jr., and Emala CW. Gi-coupled γ-aminobutyric acid-B receptors cross-regulate phospholipase C and calcium in airway smooth muscle. Am. J. Respir. Cell Mol. Biol., 45(6):1232-1238, 2011.

分野問い合わせ

E-mail: kentaro.mizuta.e6*tohoku.ac.jp(*を@に変えてください。)
TEL:022-717-8420
FAX:022-717-8404

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