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分子・再生歯科補綴学分野

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分野の紹介

　当分野は、教育ではクラウン・ブリッジ補綴学を担当しています。学部教育では、歯科医療のデジタル化の流れに沿った実践的な授業を行うとともに、歯科医学教育を充実させるべく、歯を切削する技能の客観的評価方法やシミュレーションシステムの確立に取り組んでいます。
　診療室（東北大学病院・咬合修復科）ではクラウンやブリッジ、インプラントなどの固定性補綴装置を用いた治療を専門としています。審美性の回復を目的としたクラウン・ブリッジ治療に対する当分野の診療・研究の歴史は長く、近年ではデジタル歯科医療を積極的に導入し、CAD/CAMシステムを用いたメタルフリー歯冠修復治療を専門にしています。同時に、Minimal Interventionの概念に基づく接着ブリッジ、短縮歯列、インプラント補綴治療を実践しています。一方、積極的な感染除去を基本とした歯周補綴治療を実践し、重度の歯周病患者に対する歯周インプラント補綴、短縮歯列による機能回復など、高い専門性を要する治療を手掛けています。これらの専門治療を基本に、患者様の高い満足が得られる診療に努めています。
　研究面で我々が目指すのは、補綴歯科治療を分子レベルで生物学的および材料学的に理解することです。この理解を基盤にして、歯を失うことによって損なわれたQOLを回復し、これを維持していくために必要となる技術を、従来の歯科補綴学のみならず再生医学にも求め、エビデンスをもって追求していきます。当教室では、新規インプラント材料の開発や幹細胞を応用した顎骨あるいは歯の再生医療技術の開発、時計遺伝子に着目したオルガノイド研究や、歯周組織再生を促す新規タンパク質製剤の開発に取り組んでいます。また、CAD/CAM法を用いたメタルフリー歯冠修復治療や歯科金属アレルギーについて、基礎研究と臨床研究の双方から臨床に直結するエビデンスを集積しています。
　当研究室の詳細は、「研究室HP」をご覧ください。

教員構成

江草 宏 山田 将博 新部　邦透
教授:江草 宏 准教授:山田 将博 講師:新部 邦透
教授 江草　宏 ▶ researchmap
准教授 山田　将博 ▶ researchmap
講師 新部　邦透 ▶ researchmap

主な研究テーマ

  • iPS細胞/間葉系幹細胞を基盤とする口腔組織再生技術の開発
  • バイオミメティック骨再生材料/インプラント材料の開発
  • 歯槽骨吸収における骨免疫学の研究
  • 時計遺伝子に着目したオルガノイド研究
  • 新規歯周組織再生タンパク質製剤の開発
  • テーラーメイド補綴歯科医療の確立に向けた術前診断法の開発
  • CAD/CAM法を用いたメタルフリー歯冠修復の基礎・臨床的研究
  • 歯科用金属アレルギーの基礎・臨床研究
  • 支台歯形成を可視化/スコア化したAI評価システムの開発

最近の業績

  1. Watanabe J, Iwamatsu-kobayashi Y, Kikuchi K, Kajita T, Morishima H, Yamauchi K, Yashiro Q, Nishimura H, Kanetaka H, Egusa H: Visualization of droplets and aerosols in simulated dental treatments to clarify the effectiveness of oral suction devices. J Prosthodont Res, 68(1):85-91, 2024
  2. Kurihara A, Nakamura K, Shishido S, Inagaki R, Harada A, Kanno T, Egusa H: Mechanism underlying ultraviolet-irradiation-induced discoloration of dental zirconia ceramics stabilized with 3 and 5 mol% yttria. Ceram Int, in press.
  3. Kakinuma H, Koyama S, Kondo T, Harata T, Egusa H: In vitro evaluation of shape-memory hydrogels for removable dental prostheses and optimization of phase-transition temperature for intraoral use. J Prosthet Dent, in press.
  4. Kondo T, Otake K, Kakinuma H, SatoY, Ambo S, Egusa H: Contributed equally Zinc- and fluoride-releasing bioactive glass as a novel bone substitute. J Dent Res, in press.
  5. Kondo T, Yamada M, Egusa H: Innate immune regulation in dental implant osseointegration. J Prosthodont Res, in press.
  6. Kondo T, Kakinuma H, Fujimura K, Ambo S, Otake K, Sato Y, Egusa H: Incomplete polymerization of dual-cured resin cement due to attenuated light through zirconia induces inflammatory responses. Int J Mol Sci, 24(12): 9861, 2023.
  7. Tiskratok W, Yamada M, Watanabe J, Pengyu Q, Kimura T, Egusa H: Mechanoregulation of osteoclastogenesis-inducing potentials of fibrosarcoma cell line by substrate stiffness. Int J Mol Sci, 24(10): 8959, 2023.
  8. Nattasit P, Niibe K, Yamada M, Ohori-Morita Y, Limraksasin P, Tiskratok W, Yamamoto M, Egusa H: Stiffness-Tunable Hydrogel-Sandwich Culture Modulates the YAP-Mediated Mechanoresponse in Induced-Pluripotent Stem Cell Embryoid Bodies and Augments Cardiomyocyte Differentiation. Macromol Biosci, 23(7): e2300021, 2023.
  9. Tiskratok W, Yamada M, Watanabe J, Kartikasari N, Kimura T, Egusa H: Substrate stiffness controls proinflammatory responses in human gingival fibroblasts. Sci Rep, 13(1): 1358, 2023.
  10. Iwamatsu-Kobayashi Y, Watanabe J, Kusama T, Endo H, Ikeda S, Tokuda K, Igarashi K, Egusa H: A 19-year study of dental needlestick and sharps injuries in Japan. Int Dent J, 73(1): 114-120, 2023.
  11. Akashi Y, Nagasaki A, Okawa H, Matsumoto T, Kondo T, Yatani H, Nishimura I, Egusa H: Cyclic pressure-induced cytokines from gingival fibroblasts stimulate osteoclast activity: Clinical implications for alveolar bone loss in denture wearers. J Prosthodont Res, 67(1): 77-86, 2023.
  12. Limraksasin P, Nattasit P, Manokawinchoke J, Tiskratok W, Vinaikosol N, Okawa H, Limjeerajarus CN, Limjeerajarus N, Pavasant P, Osathanon T, Egusa H: Application of shear stress for enhanced osteogenic differentiation of mouse induced pluripotent stem cells. Sci Rep, 12(1): 19021, 2022.
  13. He X, Yamada M, Watanabe J, Tiskratok W, Ishibashi M, Kitaura H, Mizoguchi I, Egusa H. Titanium nanotopography induces osteocyte lacunar-canalicular networks to strengthen osseointegration. Acta Biomater, 151(1): 613-627, 2022.
  14. Kartikasari N, Yamada M, Watanabe J, Tiskratok W, He X, Egusa H: Titania nanospikes activate macrophage phagocytosis by ligand-independent contact stimulation. Sci Rep, 12(1): 12250, 2022.
  15. Zhang M, Niibe K, Kondo T, Limraksasin P, Okawa H, Miao X, Kamano Y, Yamada M, Jiang X, Egusa H: Rapid and efficient generation of cartilage pellets from mouse induced pluripotent stem cells by transcriptional activation of BMP-4 with shaking culture. J Tissue Eng, 13: 20417314221114616, 2022.
  16. Yamada M, Kimura T, Nakamura N, Watanabe J, Kartikasari N, He X, Tiskratok W, Yoshioka H, Shinno H, Egusa H: Titanium nanosurface with a biomimetic physical microenvironment to induce endogenous regeneration of the periodontium. ACS Appl Mater Interfaces, 14(24): 27703-27719, 2022.
  17. Miao X, Niibe K, Fu Y, Zhang M, Nattasit P, Ohori-Morita Y, Nakamura T, Jiang X, Egusa H: Epiprofin transcriptional activation promotes ameloblast induction from mouse induced pluripotent stem cells via the BMP-Smad signaling axis. Front Bioeng Biotechnol, 10: 890882, 2022.
  18. Inomata M, Harada A, Kasahara S, Kusama T, Ozaki A, Katsuda Y, Egusa H: Potential complications of CAD/CAM-produced resin composite crowns on molars: A retrospective cohort study over four years. PLoS One, 17(4): e0266358, 2022.
  19. Akaishi T, Kushimoto S, Katori Y, Sugawara N, Egusa H, Igarashi K, Fujita M, Kure S, Takayama S, Abe M, Kikuchi A, Ohsawa M, Ishizawa K, Abe Y, Imai H, Inaba Y, Iwamatsu-Kobayashi Y, Nishioka T, Onodera K, Ishii T: Effectiveness of third vaccine dose for coronavirus disease 2019 during the Omicron variant pandemic: a prospective observational study in Japan. Sci Rep, 12(1): 13589, 2022.
  20. Egusa H: Leadership for the further growth of JPR. J Prosthodont Res, 66(3): vi-vii, 2022.
  21. Kartikasari N, Yamada M, Watanabe J, Tiskratok W, He X, Kamano Y, Egusa H. Titanium surface with nanospikes tunes macrophage polarization to produce inhibitory factors for osteoclastogenesis through nanotopographic cues. Acta Biomater, 137: 316-330, 2022.
  22. Ohori-Morita Y, Niibe K, Limraksasin P, Nattasit P, Miao X, Yamada M, Mabuchi Y, Matsuzaki Y, Egusa H: Novel Mesenchymal Stem Cell Spheroids with Enhanced Stem Cell Characteristics and Bone Regeneration Ability. Stem Cells Transl Med, 11(4): 434-449, 2022.
  23. Fakhruddin KS, Samaranayake LP, Hamoudi RA, Ngo HC, Egusa H: Diversity of site-specific microbes of occlusal and proximal lesions in severe- early childhood caries (S-ECC). J Oral Microbiol, 14(1): 2037832, 2022.
  24. Fukuyasu S, Kayashima H, Moribayashi A, Matsuoka S, Nagasaki A, Okawa H, Yatani H, Saeki M, Egusa H. Cell-based double-screening method to identify a reliable candidate for osteogenesis-targeting compounds. Biomedicines, 10:426, 2022.
  25. Egusa H: JPR starts 2022 with a new design -Towards a new frontier in prosthodontics. J Prosthodont Res, 66(1): vi-vii, 2022.
  26. Limraksasin P, Egusa H: A method for in vitro fabrication of hybrid bone/cartilage tissue using mouse induced pluripotent stem cells. iPS Cells: Methods and Protocols 2nd Edition. Springer Nature, 2454: 509-520, 2022.
  27. Miao X, Niibe K, Zhang M, Liu Z, Nattasit P, Ohori-Morita Y, Nakamura T, Jiang X, Egusa H: Stage-specific role of amelx activation in stepwise ameloblast induction from mouse induced pluripotent stem cells. Int J Mol Sci, 22(13): 7195, 2021.
  28. Ozaki A, Shishido S, Nakamura K, Harada A, Katsuda Y, Kanno T, Egusa H: Impact of adhesive primer and light-curing on polymerization kinetics of self-adhesive resin cement in association with free radical reaction. Eur J Oral Sci, 129(6): e12828, 2021.
  29. Egusa H: JPR continues to grow as a leading dental journal and international public asset. J Prosthodont Res, 65(3): vi, 2021.
  30. Osathanon T, Egusa H: Notch signaling in induced pluripotent stem cells. Molecular Players in iPSC Technology, Volume 12, 1st Edition. Ed: Birbrair A, Elsevier, Amsterdam, 249-284, 2021.
  31. Miura S, Yamauchi S, Kasahara S, Katsuda Y, Fujisawa M, Egusa H: Clinical evaluation of monolithic zirconia crowns: A failure analysis of clinically obtained cases from a 3.5-year study. J Prosthodont Res, 65(2): 148-154, 2021.
  32. Manokawinchoke J, Pavasant P, Limjeerajarus CN, Limjeerajarus N, Osathanon T, Egusa H: Mechanical loading and the control of stem cell behavior. Arch Oral Biol,125: 105092, 2021.
  33. Niibe K, Ohori-Morita Y, Zhang M, Mabuchi Y, Matsuzaki Y, Egusa H: A shaking-culture method for generating bone marrow derived mesenchymal stromal/stem cell-spheroids with enhanced multipotency in vitro. Front Bioeng Biotechnol, 8: 590332, 2020.
  34. Limraksasin P, Kosaka Y, Zhang M, Horie N, Kondo T, Okawa H, Yamada M, Egusa H: Shaking culture enhances chondrogenic differentiation of mouse induced pluripotent stem cell constructs. Sci Rep, 10(1): 14996, 2020.
  35. Harada A, Shishido S, Barkarmo S, Inagaki R, Kanno T, Örtengren U, Egusa H, Nakamura K: Mechanical and microstructural properties of ultra-translucent dental zirconia ceramic stabilized with 5 mol% yttria. J Mech Behav Biomed Mater, 111: 103974, 2020.
  36. Hong G, Chang TY, Terry A, Chuenjitwongsa S, Park YS, Tsoi KH, Sun JX, Kusdhany S, Egusa H, Yamada S, Kwon JS, Seow LL, Garcia CG, Loke WM, Auychai P, Hsu ML: Guidelines for the innovation of dental education under the coronavirus disease 2019 pandemic situation. J Oral Sci, 63(1): 107-110, 2020.
  37. Limraksasin P, Kondo T, Zhang M, Okawa H, Osathanon T, Pavasant P, Egusa H: In vitro fabrication of hybrid bone/cartilage complex using mouse induced pluripotent stem cells. Int J Mol Sci, 21(2): 581, 2020.
  38. Limraksasin P, Okawa H, Zhang M, Kondo T, Osathanon T, Pavasant P, Egusa H: Size-optimized micro-space culture facilitates differentiation of mouse induced pluripotent stem cells into osteoid-rich bone constructs. Stem Cells Int, Article ID 7082679, 2020.
  39. Watahiki A, Shimizu K, Hoshikawa S, Chiba M, Kitamura H, Egusa H, Fukumoto S, Inuzuka H: Lipin-2 degradation elicits a proinflammatory gene signature in macrophages. Biochem Biophys Res Commun, 524(2): 477-483, 2020.
  40. Okawa H, Egusa H, Nishimura I: Implications of the circadian clock in implant dentistry. Dent Mater J, 39(2): 173-180, 2020.
  41. Yamada M, Watanabe J, Ueno T, Ogawa T, Egusa H: Cytoprotective preconditioning of osteoblast-Like cells with N-acetyl-L-cysteine for bone regeneration in cell therapy. Int J Mol Sci, 20(20): 5199, 2019.
  42. Yamauchi S, Miura S, Kasahara S, Sun J, Egusa H: A thick frame decreases the fracture toughness of veneering ceramics used for zirconia-based all-ceramic restorations. J Prosthodont Res, 63: 184-192, 2019.
  43. Miura S, Kasahara S, Yamauchi S, Katsuda Y, Harada A, Aida J, Egusa H: A possible risk of CAD/CAM-produced composite resin premolar crowns on a removable partial denture abutment tooth: A 3-year retrospective cohort study. J Prosthodont Res, 63: 78-84, 2019.
  44. Watanabe J, Yamada M, Niibe K, Zhang M, Kondo T, Ishibashi M, Egusa H: Preconditioning of bone marrow-derived mesenchymal stem cells with N-acetyl-L-cysteine enhances bone regeneration via reinforced resistance to oxidative stress. Biomaterials, 185: 25-38, 2018.
  45. Nakazawa K, Nakamura K, Harada A, Shirato M, Inagaki R, Ortengren U, Kanno T, Niwano Y, Egusa H: Surface properties of dental zirconia ceramics affected by ultrasonic scaling and low-temperature degradation. PLoS One, 13(9): e0203849, 2018.
  46. Ankyu S, Nakamura K, Harada A, Inagaki R, Kastuda Y, Kanno T, Niwano Y, Ortengren U, Egusa H: Influence of microscale expansion and contraction caused by thermal and mechanical fatigue on retentive strength of CAD/CAM-generated resin-based composite crowns. J Mech Behav Biomed Mater, 86: 89-97, 2018.
  47. Zhang M, Yu W, Niibe K, Zhang W, Egusa H, Jiang X: The effects of platelet-derived growth factor-BB on bone marrow stromal cell-mediated vascularized bone regeneration. Stem Cells Int, Article ID 3272098, 2018.
  48. Shishido S, Miyano R, Nakashima T, Matsuo H, Iwatsuki M, Nakamura K, Kanno T, Egusa H, Niwano Y: A novel pathway for the photooxidation of catechin in relation to its prooxidative activity. Sci Rep, 8(1): 12888, 2018.
  49. Tenkumo T, Vanegas Saenz JR, Nakamura K, Shimuzu Y, Sokolova V, Epple M, Kamano Y, Egusa H, Sugaya T, Sasaki K: Prolonged release of bone morphogenetic protein-2 in vivo by gene transfection with DNA-functionalized calcium phosphate nanoparticle-loaded collagen scaffolds. Mater Sci Eng C Mater Biol Appl, 92: 172-183, 2018.
  50. Tateshima S, Kaneko N, Yamada M, Duckwiler G, Vinuela F, Ogawa T: Increased affinity of endothelial cells to NiTi using ultraviolet irradiation: An in vitro study. J Biomed Mater Res A, 106(4): 1034-1038, 2018.

分野問い合わせ

医局長・山田 将博
E-mail：crbr.mrpros*tohoku.ac.jp（*を＠に変えてください。）
TEL：022-717-8363

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