東北大学大学院歯学研究科・歯学部

③ リアルワールドデータを用いたエビデンスの創出

リアルワールドデータを用いた分析により、歯科医療・歯科保健の推進の基礎となるエビデンスの創出に取り組んでいます。

1. Abbas H, Takeuchi K, Kusama T, Kiuchi S, Kondo K, Osaka K. Oral health and happiness after 3-years with causal mediation of oral functions. Journal of Dentistry. 2025;162:106036.
2. Abbas H, Takeuchi K, Kusama T, Kiuchi S, Osaka K. Oral Health and Social Isolation After 6 Years: Mediation of Oral Functions. Community Dentistry and Oral Epidemiology. 2025. (adv.pub.)
3. Abdurrahman F, Kusama T, Tamada Y, Kiuchi S, Saito M, Ojima T, Aida J, Kondo K, Osaka K, Takeuchi K. Tooth loss, dental prosthesis use, and cause-specific mortality in older Japanese adults: a 7-year cohort study. Scientific Reports. 2025;15(1):40650.
4. Asaeda M, Nishimura R, Suma S, Tsukamoto M, Kadomatsu Y, Kubo Y, Okada R, Nagayoshi M, Tamura T, Hishida A, Takeuchi K, Goto C, Imaeda N, Wakai K, Arimoto N, Maehara T, Naito M. Association of Number of Teeth Present With Nutrient Intake and Food Group Consumption. Journal of Oral Rehabilitation. 2025;52(10):1664-73.
5. Blechter B, Wang X, Dai J,…, Takeuchi K,…, Zhang H. Stratifying lung adenocarcinoma risk with multi-ancestry polygenic risk scores in East Asian never-smokers. J Natl Cancer Inst. 2025. doi: 10.1093/jnci/djaf272. (in press).
6. Fujita M, Takeuchi K, Tamada Y, Kusama T, Yamamoto T, Kondo K, Osaka K. Socioeconomic Inequalities in Oral Frailty Among Older Adults: A Causal Mediation Analysis on the Role of Prevention From Tooth Loss. Journal of Oral Rehabilitation. 2025;52(12):2412-9.
7. Hoshi-Harada M, Takeuchi K, Kusama T, Aida J, Egusa H, Osaka K. Removable partial denture, complete denture, and fixed partial denture use and health-related quality of life among older adults with tooth loss: A JAGES cross-sectional study. Journal of Prosthodontic Research. 2025. (adv.pub.)
8. Iwata M, Kinugawa A, Hanazato M, Kondo K, Osaka K, Takeuchi K. Perceived indoor thermal environment and depressive symptoms among older adults in the Japan Gerontological Evaluation Study. Scientific Reports. 2025;15(1):30871.
9. Kinugawa A, Takeuchi K, Tamada Y, Kusama T, Sato M, Maeda M, Murata F, Osaka K, Fukuda H. Differences in health care expenditure due to the comorbidity status of periodontal disease and diabetes mellitus. Journal of Periodontology. 2025;96:760–8.
10. Kiuchi S, Kusama T, Aida J, Osaka K, Takeuchi K. Willingness to pay and its determinants for missing tooth replacement among older adults: A cross-sectional study in Japan. The Journal of Prosthetic Dentistry. 2025. (adv.pub.).
11. Kiuchi S, Nakaya K, Cooray U, Takeuchi K, Motoike I, Nakaya N, Taki Y, Koshiba S, Mugikura S, Osaka K, Hozawa A. A principal component analysis of metabolome and cognitive decline among Japanese older adults: cross-sectional analysis using Tohoku Medical Megabank Cohort Study. J Epidemiol 2025;35(1):39-46.
12. Kusama T, Aida J, Osaka K, Takeuchi K. Association between infrequent denture cleaning and all-cause mortality risk among community-dwelling older adults: Findings from a six-year cohort study. The Journal of Prosthetic Dentistry. 2025;134(4):1171.e1-.e7.
13. Kusama T, Komiyama T, Takeuchi K, Sabbah W, Osaka K, Gallagher JE. Bidirectional longitudinal associations between subjective oral health and subjective well-being. Archives of Gerontology and Geriatrics. 2025;131:105740.
14. Kusama T, Tamada Y, Kiuchi S, Saito M, Ojima T, Aida J, Kondo K, Osaka K, Takeuchi K. Chewing difficulty, swallowing problems, xerostomia and cause-specific mortality among older adults: A 7-year follow-up JAGES cohort study. Geriatrics & Gerontology International. 2025;25(10):1332–40.
15. Kusama T, Tamada Y, Osaka K, Takeuchi K. Periodontal Care Is Associated With a Lower Risk of Dialysis Initiation in Middle-Aged Patients With Type 2 Diabetes Mellitus: A 6-Year Follow-Up Cohort Study Based on a Nationwide Healthcare Database. Journal of Clinical Periodontology. 2025;52(5):717-26.
16. Miyano T, Kusama T, Hoshi-Harada M, Osaka K, Takeuchi K. Clustering analysis of partial tooth loss patterns and their association with cardiovascular health using a Japanese claims database. J Am Med Dir Assoc. 2025. (in press).
17. Miyano T, Tamada Y, Kusama T, Osaka K, Takeuchi K. Impact of posterior occlusal contact loss on cardiovascular disease using a Japanese claims database. Scientific Reports. 2025;15(1):16693.
18. Nagayoshi M, Tamai M, Takeuchi K, Yamanashi H, Koyamatsu J, Nonaka F, Nobusue K, Honda Y, Kawashiri S-y, Nagata Y, Maeda T. Frequency of Conversation, Laughter and Other Vocalising Opportunities in Daily Life and Maximum Tongue Pressure: The Goto Longevity Study. Journal of Oral Rehabilitation. 2025;52(9):1288-96.
19. Nishimura K, Imai Y, Tsurumi Y, Kusama T, Miura C, Sato A, Muraki K, Tsuchiya S, Igarashi K. Long-term clinical outcomes of alveolar bone grafting in patients with unilateral cleft lip and palate: A retrospective study of the effects of orthodontic treatment with edgewise appliances. Heliyon. 2025;11(10):e43116.
20. Sato M, Hoshi-Harada M, Takeuchi K, Kusama T, Ikeda T, Kiuchi S, Saito M, Nakaya N, Osaka K. Combined association of social isolation and loneliness with frailty onset among independent older adults: A JAGES cohort study. Archives of Gerontology and Geriatrics. 2025;136:105914.
21. Shiota C, Takeuchi K, Kusama T, Tamada Y, Oda F, Maeda M, Osaka K, Fukuda H. No Cost Sharing for Public Assistance Recipients and Health Service Usage in Japan. JAMA Health Forum. 2025;6(10):e253713-e.
22. Tadokoro D, Honda K, Kusama T, Takeuchi K, Osaka K, Aida J. School-Based Fluoride Mouth-Rinse Programs and Dental Caries Treatment Expenditure: An Ecological Study of the NDB Open Data Japan. Community Dentistry and Oral Epidemiology. 2025;53(2):216-23.
23. Tamada Y, Takeuchi K, Tabuchi T. Secondhand tobacco exposure assessed using urinary cotinine among 10-year-old children in Japan: An 11-year repeated cross-sectional study. Nicotine Tob Res. 2025;27(3):534-541.
24. 原田真奈実，草間太郎，小坂健，竹内研時. 口腔の健康と全身の健康関連QOLの関連. 口腔衛生学会雑誌: 2025;76(1). (in press).

1. Ishimura K, Sakaniwa R, Shirai K, Aida J, Takeuchi K, Kondo K, Iso H. Frequency of Going Outdoors and Risk of Poor Oral Health Among Older Japanese Adults: A Longitudinal Cohort From the Japan Gerontological Evaluation Study. Journal of Epidemiology. 2024;34(2):63-9.
2. Kasahara C, Tamura T, Wakai K,…, Takeuchi K, Matsuo K; J-MICC Study Group. Association between consumption of small fish and all-cause mortality among Japanese: the Japan Multi-Institutional Collaborative Cohort Study. Public Health Nutr. 2024;27(1):e135.
3. Kino S, Tamada Y, Takeuchi K, Nakagomi A, Shiba K, Kusama T, Yamamoto T, Aida J. Exploring the relationship between oral health and multiple health conditions: An outcome-wide approach. Journal of Prosthodontic Research. 2024;68(3):415-24.
4. Kinugawa A, Yamamoto T, Kusama T, Takeuchi K, Osaka K. Association between Number of Teeth and Eating out of Home: A 2019 Statistical Survey of the Japanese Representative Population. Nutrients. 2024;16(13):2102.
5. Kiuchi S, Matsuyama Y, Takeuchi K, Kusama T, Cooray U, Osaka K, Aida J. Number of Teeth and Dementia-free Life Expectancy: A 10-Year Follow-Up Study from the Japan Gerontological Evaluation Study. Journal of the American Medical Directors Association. 2024;25(11):105258.
6. Kiuchi S, Nakaya K, Cooray U, Takeuchi K, Motoike IN, Nakaya N, Taki Y, Koshiba S, Mugikura S, Osaka K, Hozawa A. A principal component analysis of metabolome and cognitive decline among Japanese older adults: cross-sectional analysis using Tohoku Medical Megabank Cohort Study. Journal of Epidemiology. 2024;35(1):39-46.
7. Kiuchi S, Takeuchi K, Saito M, Kusama T, Nakazawa N, Fujita K, Kondo K, Aida J, Osaka K. Differences in Cumulative Long-Term Care Costs by Dental Visit Pattern Among Japanese Older Adults: The JAGES Cohort Study. The Journals of Gerontology: Series A. 2024;79(9).
8. Koyanagi YN, Nakatochi M, Namba S,…, Takeuchi K,…, Matsuo K. Genetic architecture of alcohol consumption identified by a genotype-stratified GWAS and impact on esophageal cancer risk in Japanese people. Sci Adv. 2024;10(4): eade2780.
9. Kudo Y, Takeuchi K, Kusama T, Kojima T, Waguri-Nagaya Y, Nagayoshi M, Kondo K, Mizuta K, Osaka K, Kojima M. Differences in prevalence of self-reported oral hypofunction between older adult patients with rheumatoid arthritis and the general older population: A cross-sectional study using propensity score matching. Journal of Oral Rehabilitation. 2024;51(6):924-30.
10. Kusama T, Takeuchi K, Kiuchi S, Aida J, Osaka K. Poor oral health and dementia risk under time-varying confounding: A cohort study based on marginal structural models. Journal of the American Geriatrics Society. 2024;72(3):729-41.
11. Kusama T, Takeuchi K, Kiuchi S, Aida J, Osaka K. The association between objective and subjective oral health conditions and the presence of anorexia of aging among Japanese older Adults. Appetite. 2024;198:107332.
12. Kusama T, Takeuchi K, Kiuchi S, Tamada Y, Tabuchi T, Osaka K. Tooth loss mediates the association between smoking and an increased risk of dementia among older adults: The JAGES prospective cohort study. Journal of Clinical Periodontology. 2024;51(12):1610-8.
13. Kusama T, Tamada Y, Maeda M, Murata F, Osaka K, Fukuda H, Takeuchi K. Changes in the utilization of outpatient and visiting dental care and per-attendance care cost by age groups during COVID-19 pandemic waves in Japan: A time-series analysis from LIFE study. Journal of Epidemiology. 2024;34(11):553-9.
14. Li W, Li Y, Gao S, Huang N, Kojima I, Kusama T, Ou Y, Iikubo M, Niu X. Integrating lipid metabolite analysis with MRI-based transformer and radiomics for early and late stage prediction of oral squamous cell carcinoma. BMC Cancer. 2024;24(1):795.
15. Miyano T, Tamada Y, Kusama T, Osaka K, Takeuchi K. Longitudinal association between posterior occlusal contact and dementia development in a large retrospective cohort study using a Japanese claims database. Scientific Reports. 2024;14(1):27513.
16. Nagayoshi M, Hishida A, Shimizu T,…, Takeuchi K, Wakai K. BMI and cardiometabolic traits in Japanese: a Mendelian randomization study. J Epidemiol. 2024;34(2):51-62.
17. Nakazawa N, Takeuchi K, Kusama T, Kiuchi S, Kondo K, Osaka K. Dental prosthesis use moderates association between tooth loss and risk of depressive symptoms in older adults with severe tooth loss: The JAGES cohort trial. Journal of Prosthodontic Research. 2024;68(4):578-84.
18. Okumura T, Nakagawa K, Yoshimi K, Saito M, Ito K, Itoda M, Takeuchi K, Mizutani S, Yoshida M, Watanabe Y, Tohara H. Present state and perceived future use of teledentistry in long-term care facilities in Japan: A cross-sectional study. Digit Health. 2024;10:20552076241282394.
19. Saito M, Watanabe R, Tamada Y, Takeuchi K, Tani Y, Kondo K, Ojima T. Social disconnection and suicide mortality among Japanese older adults: A seven-year follow-up study. Soc Sci Med. 2024;347:116778.
20. Shiraishi K, Takahashi A, Momozawa,…, Takeuchi K,…, Kohno T. Identification of telomere maintenance gene variations related to lung adenocarcinoma risk by genome-wide association and whole genome sequencing analyses. Cancer Commun (Lond). 2024;44(2):287-293.
21. Tamada Y, Kusama T, Maeda M, Murata F, Osaka K, Fukuda H, Takeuchi K. Public Periodontal Screening Increases Subsequent Regular Dental Visits: The Life Study. JDR Clinical & Translational Research. 2024;10(2):180-9.
22. Tamada Y, Kusama T, Ono S, Maeda M, Murata F, Osaka K, Fukuda H, Takeuchi K. Validity of claims-based definition of number of remaining teeth in Japan: Results from the Longevity Improvement and Fair Evidence Study. PLOS ONE. 2024;19(5):e0299849.
23. Tamada Y, Takeuchi K, Kusama T, Maeda M, Murata F, Osaka K, Fukuda H. Bivalent mRNA vaccine effectiveness against COVID-19 among older adults in Japan: a test-negative study from the VENUS study. BMC Infectious Diseases. 2024;24(1):135.
24. Tamada Y, Takeuchi K, Kusama T, Saito M, Ohira T, Shirai K, Yamaguchi C, Kondo K, Aida J, Osaka K. Reduced number of teeth with and without dental prostheses and low frequency of laughter in older adults: Mediation by poor oral function. Journal of Prosthodontic Research. 2024;68(3):441-8.
25. Tamada Y, Takeuchi K, Tabuchi T. Secondhand Tobacco Exposure Assessed Using Urinary Cotinine Among 10-Year-Old Children in Japan: An 11-Year Repeated Cross-sectional Study. Nicotine & Tobacco Research. 2024;27(3):534-41.
26. Tsukamoto M, Hishida A, Tamura T,…, Takeuchi K, Wakai K, Matsuo K. GWAS of folate metabolism with gene-environment interaction analysis revealed the possible role of lifestyles in the control of blood folate metabolites in Japanese - the J-MICC Study. J Epidemiol. 2024;34(5):228–237.
27. Yamamoto T, Cooray U, Kusama T, Kiuchi S, Abbas H, Osaka K, Kondo K, Aida Jl. Childhood Socioeconomic Status Affects Dental Pain in Later Life. JDR Clinical & Translational Research. 2024;0(0):23800844241271740.
28. Yamamoto T, Mochida Y, Irie K, Altanbagana NU, Fuchida S, Aida J, Takeuchi K, Fujita M, Kondo K. Regional Inequalities in Oral Frailty and Social Capital. JDR Clin Trans Res. 2024;9(4):368-377.

1. Abbas H, Takeuchi K, Kiuchi S, Kondo K, Osaka K. Exposure to household dysfunction at childhood and later number of teeth among older Japanese adults: A life course study from the Japan Gerontological Evaluation Study. J Public Health Dent. 2023;83(3):299-308.
2. Abbas H, Takeuchi K, Kiuchi S, Kondo K, Osaka K. Exposure to household dysfunction at childhood and later number of teeth among older Japanese adults: A life course study from the Japan Gerontological Evaluation Study. Journal of Public Health Dentistry. 2023;83(3):299-308.
3. Abbas H, Takeuchi K, Koyama S, Osaka K, Tabuchi T. Association Between Toothbrushing Habits and COVID-19 Symptoms. Int Dent J. 2023;73(2):302-10.
4. Abbas H, Takeuchi K, Osaka K, Guarnizo-Herreño CC, Tsakos G, Watt RG. The role of science communication and academic health advocacy in improving population oral health and tackling inequalities. Community Dentistry and Oral Epidemiology. 2023;51(4):606-8.
5. Hanyuda A, Goto A, Katagiri R,…, Takeuchi K, Narita A, Hozawa A, Kinoshita K, Shimizu A, Tanno K, Matsuo K, Tsugane S, Wakai K, Sasaki M, Yamamoto M, Iwasaki M. Investigating the association between glycaemic traits and colorectal cancer in the Japanese population using Mendelian randomisation. Sci Rep. 2023;13(1):7052.
6. Hara M, Nishida Y, Tanaka K,…, Takeuchi K, Tamura T, Hishida A, Tsukamoto M, Kadomatsu Y, Matsuo K, Oze I, Haruo M, Miho K, Takezaki T, Ibusuki R, Suzuki S, Nakagawa-Senda H, Matsui D, Koyama T, Kuriki K, Takashima N, Nakamura Y, Arisawa K, Katsuura-Kamano S, Wakai K. Moderate-to-vigorous physical activity and sedentary behavior are independently associated with renal function: a cross-sectional study. J Epidemiol. 2023;33(6):285-293.
7. Inoue Y, Cooray U, Ishimaru M, Saito K, Takeuchi K, Kondo K, Aida J. Oral self-care, pneumococcal vaccination, and pneumonia among Japanese older people, assessed with machine learning. The Journals of Gerontology: Series A. 2023.
8. Iwamatsu-Kobayashi Y, Watanabe J, Kusama T, Endo H, Ikeda S, Tokuda K, Igarashi K, Egusa H. A 19-Year Study of Dental Needlestick and Sharps Injuries in Japan. International Dental Journal. 2023;73(1):114-20.
9. Kinugawa A, Kusama T, Takeuchi K, Aida J, Kiuchi S, Katagiri R, et al. Association between dietary pattern and insomnia symptoms among independent older adults: A cross-sectional study based on JAGES. Sleep Med. 2023;112:70-6.
10. Kusama T, Takeuchi K, Kiuchi S, Aida J, Hikichi H, Sasaki S, Kondo K, Osaka K. Dental prosthesis use is associated with higher protein intake among older adults with tooth loss. Journal of Oral Rehabilitation. 2023;50(11):1229-38.
11. Kusama T, Takeuchi K, Tamada Y, Kiuchi S, Osaka K, Tabuchi T. Compliance Trajectory and Patterns of COVID-19 Preventive Measures, Japan, 2020-2022. Emerging Infectious Diseases. 2023;29(9):1747-56.
12. Maehara T, Nishimura R, Yoshitake A, Tsukamoto M, Kadomatsu Y, Kubo Y, Okada R, Nagayoshi M, Tamura T, Hishida A, Takeuchi K, Wakai K, Naito M. Association of daily physical activity and leisure-time exercise with dysphagia risk in community-dwelling older adults: a cross-sectional study. Scientific Reports. 2023;13(1):10893.
13. Nagayoshi M, Takeuchi K, Tamada Y,..., Wakai K. Sex-specific Relationship between Stress Coping Strategies and All-Cause Mortality: Japan Multi-Institutional Collaborative Cohort Study. J Epidemiol. 2023;33(5):236-245.
14. Nakamura S, Fang X, Saito Y,…, Takeuchi K, Wakai K. Effects of gene-lifestyle interactions on obesity based on a multi-locus risk score: A cross-sectional analysis. PLoS One. 2023;18(2):e0279169.
15. Nakazawa N, Kusama T, Takeuchi K, Kiuchi S, Yamamoto T, Kondo K, Osaka K, Aida J. Co-Payments and Inequality in Gingival Bleeding and Dental Visits. International Dental Journal. 2023;73(5):628-35.
16. Nindita Y, Nakatochi M, Ibusuki R,…, Takeuchi K, Wakai K. Population-Based Impact of Smoking, Drinking, and Genetic Factors on HDL-Cholesterol Levels in J-MICC Study Participants. J Epidemiol. 2023;33(4):193–200.
17. Shi J, Shiraishi K, Choi J,…, Takeuchi K,…, Lan Q. Genome-wide association study of lung adenocarcinoma in East Asia and comparison with a European population. Nat Commun. 2023;14(1):3043.
18. Shiota C, Kusama T, Takeuchi K, Kiuchi S, Osaka K. Oral Hypofunction and Risk of Weight Change among Independent Older Adults. Nutrients. 2023;15(20):4370.
19. Takao N, Furuta M, Takeshita T, Kageyama S, Goto T, Zakaria MN, Takeuchi K, Yamashita Y. Association of second-hand smoke exposure, quantified by salivary cotinine, with dental caries in Japanese adolescents. Journal of Oral Science. 2023;65(2):107-10.
20. Tamada Y, Takeuchi K, Kusama T, Maeda M, Murata F, Osaka K, Fukuda H. Effectiveness of COVID-19 vaccines against infection in Japan: A test-negative study from the VENUS study. Vaccine. 2023;41(37):5447-53.
21. Tani Y, Yamamoto T, Kusama T, Kinugawa A, Aida J, Fujiwara T, Kondo K. Cooking skills modify the association between oral health and mortality. Age and Ageing. 2023;52(9):afad180.
22. Yamamoto-Kuramoto K, Kiuchi S, Takeuchi K, Kusama T, Nakazawa N, Tamada Y, et al. Oral status and incident functional disability: A 9-year prospective cohort study from the JAGES. Arch Gerontol Geriatr. 2023;111:105009.
23. Yamamoto-Kuramoto K, Kusama T, Kiuchi S, Kondo K, Osaka K, Takeuchi K, Aida J. Lower socio-economic status in adolescence is associated with poor oral health at an older age: Mediation by social and behavioural factors. Gerodontology. 2023;40(4):509-17.
24. 谷直道, 竹内研時, 福田治久. 地域住民の成人歯科健診における歯周ポケット検査と糖尿病発症の関連性: LIFE Study. 日本公衆衛生雑誌. 2023;70(1):39-47.
25. 野口有紀, 藤田美枝子, 種村崇, 竹内研時, 吉田直樹. 高齢者における緑茶摂取と主観的な口腔健康状態との関連‐横断研究より‐. 東海公衆衛生雑誌. 2023;11(1):65-70.
26. 齋藤義信, 小熊祐子, 中村翔, 成松宏人, 中嶋綾子, 池崎裕昭, 田中恵太郎, 原めぐみ, 玉田雄大, 永吉真子, 田村高志, 菱田朝陽, 尾瀬功, 谷山祐香里, 三上春夫, 永瀬浩喜, 嶽﨑俊郎, 指宿りえ, 鈴木貞夫, 大谷隆浩, 小山晃英, 渡邉功, 栗木清典, 喜多義邦, 高嶋直敬, 有澤孝吉, 釜野桜子, 竹内研時, 若井建志, J-MICC研究グループ. 質問紙で調査した成人の身体活動：日本多施設共同コーホート研究（J-MICC Study）. 運動疫学研究. 2023;25(1):112-113.

1. Aida J, Takeuchi K, Furuta M, Ito K, Kabasawa Y, Tsakos G. Burden of Oral Diseases and Access to Oral Care in an Ageing Society. International Dental Journal. 2022;72(4, Supplement):S5-S11.
2. Fujii R, Hishida A, Nakatochi M,…, Takeuchi K, Wakai K; J-MICC Study Group. Associations of Genome-Wide Polygenic Risk Score and Risk Factors With Hypertension in a Japanese Population. Circ Genom Precis Med. 2022;15(4):e003612.
3. Fujii R, Hishida A, Nishiyama T,…, Takeuchi K, Wakai K. Assessing the relationship between high-sensitivity C-reactive protein and kidney function employing mendelian randomization in a Japanese community based J-MICC Study. J Epidemiol. 2022;32(11):483-488.
4. Furukawa T, Nishida Y, Hara M,…, Takeuchi K, Wakai K; Japan Multi-Institutional Collaborative Cohort (J-MICC) Study Group. Effect of the interaction between physical activity and estimated macronutrient intake on HbA1c: population-based cross-sectional and longitudinal studies. BMJ Open Diabetes Res Care. 2022;10(1): e002479.
5. Furuta M, Takeuchi K, Takeshita T, Shibata Y, Suma S, Kageyama S, Asakawa M, Shimazaki Y, Hata J, Ninomiya T, Yamashita Y. Baseline periodontal status and modifiable risk factors are associated with tooth loss over a 10-year period: Estimates of population attributable risk in a Japanese community. Journal of Periodontology. 2022;93(4):526-36.
6. Hishida A, Yamada H, Ando Y,…, Takeuchi K, Wakai K. Investigation of miRNA expression profiles using cohort samples reveals potential early detectability of colorectal cancers by serum miR-26a-5p before clinical diagnosis. Oncol Lett. 2022;23(3):87.
7. Inomata M, Harada A, Kasahara S, Kusama T, Ozaki A, Katsuda Y, Egusa H. Potential complications of CAD/CAM-produced resin composite crowns on molars: A retrospective cohort study over four years. PloS one. 2022;17(4):e0266358-e.
8. Iwagami M, Goto A, Katagiri R,…, Takeuchi K, Yamamoto M, Sasaki M, Matsuo K, Tsugane S, Wakai K, Iwasaki M. Blood lipids and the risk of colorectal cancer: Mendelian randomization analyses in the Japanese Consortium of Genetic Epidemiology studies. Cancer Prev Res (Phila). 2022;15(12): 827-836.
9. Kinugawa A, Kusama T, Yamamoto T, Kiuchi S, Nakazawa N, Kondo K, Osaka K, Aida J. Association of poor dental status with eating alone: A cross-sectional Japan gerontological evaluation study among independent older adults. Appetite. 2022;168:105732-.
10. Koga K, Hara M, Shimanoe C,…, Takeuchi K, Wakai K. Association of perceived stress and coping strategies with the renal function in middle-aged and older Japanese men and women. Sci Rep. 2022;12(1): 291.
11. Kusama T, Kiuchi S, Takeuchi K, Ikeda T, Nakazawa N, Kinugawa A, Osaka K, Tabuchi T. Information Usage and Compliance with Preventive Behaviors for COVID-19: A Longitudinal Study with Data from the JACSIS 2020/JASTIS 2021. Healthcare. 2022;10(3):521.
12. Kusama T, Kiuchi S, Tani Y, Aida J, Kondo K, Osaka K. The lack of opportunity to eat together is associated with an increased risk of weight loss among independent older adults: a prospective cohort study based on the JAGES. Age and Ageing. 2022;51(3):afac022.
13. Kusama T, Nakazawa N, Takeuchi K, Kiuchi S, Osaka K. Free Sugar Intake and Periodontal Diseases: A Systematic Review. Nutrients. 2022;14(21):4444.
14. Kusama T, Takeuchi K, Kiuchi S, Aida J, Kondo K, Osaka K. Weight Loss Mediated the Relationship between Tooth Loss and Mortality Risk. J Dent Res. 2022;102(1):45-52.
15. Ma J, Furuta M, Uchida K, Takeshita T, Kageyama S, Asakawa M, Takeuchi K, Suma S, Sakata S, Hata J, Sohn W, Ninomiya T, Yamashita Y. Yogurt product intake and reduction of tooth loss risk in a Japanese community. Journal of Clinical Periodontology. 2022;49(4):345-52.
16. Matsunaga T, Kadomatsu Y, Tsukamoto M,…, Takeuchi K, Wakai K. Associations of breastfeeding history with metabolic syndrome and cardiovascular risk factors in community-dwelling parous women: The Japan Multi-Institutional Collaborative Cohort Study. PLoS One. 2022;17(1): e0262252.
17. Nakamura Y, Tamura T, Narita A,…, Takeuchi K, Wakai K; J-MICC Research Group Consortium. A genome-wide association study on adherence to low-carbohydrate diets in Japanese. Eur J Clin Nutr. 2022;76(8):1103-1110.
18. Nakayama A, Kawamura Y, Toyoda Y, Shimizu S, Kawaguchi M, Aoki Y, Takeuchi K, Okada R, Kubo Y, Imakiire T, Iwasawa S, Nakashima H, Tsunoda M, Ito K, Kumagai H, Tkada T, Ichida K, Shinomiya N, Matsuo H. Genetic-epidemiological analysis of hypouricemia from 4,993 Japanese on nonfunctional variants of URAT1/SLC22A12 gene. Rheumatology. 2022;61(3):1276-1281.
19. Nakazawa N, Kusama T, Cooray U, Yamamoto T, Kiuchi S, Abbas H, Yamamoto T, Kondo K, Osaka K, Aida J. Large contribution of oral status for death among modifiable risk factors in older adults: the JAGES prospective cohort study. The Journals of Gerontology: Series A. 2022;78(1):167-73.
20. Nguyen TV, Arisawa K, Katsuura-Kamano S,…, Takeuchi K, Wakai K. Associations of metabolic syndrome and metabolically unhealthy obesity with cancer mortality: The Japan Multi-Institutional Collaborative Cohort (J-MICC) study. PLoS One. 2022;8;17(7):e0269550.
21. Ohashi M, Miura K, Takashima N,…, Takeuchi K, Kita Y, Wakai K; Japan Multi-institutional Collaborative Cohort (J-MICC) Study Group. The association of reproductive history with hypertension and obesity according to menopausal status: the J-MICC Study. Hypertens Res. 2022;45(4):708-714.
22. Omichi C, Koyama T, Kadotani H,…, Takeuchi K, Wakai K; J-MICC Study Group. Irregular sleep and all-cause mortality: A large prospective cohort study. Sleep Health. 2022;S2352-7218(22)00150-4.
23. Saita K, Sumitani M, Nishizawa D, Tamura T, Ikeda K, Wakai K, Sudo Y, Abe H, Otonari J, Ikezaki H, Takeuchi K, Hishida A, Tanaka K, Shimanoe C, Takezaki T, Ibusuki R, Oze I, Ito H, Ozaki E, Matsui D, Nakamura Y, Kusakabe M, Suzuki S, Nakagawa-Senda H, Arisawa K, Katsuura-Kamano S, Kuriki K, Kita Y, Nakamura Y, Momozawa Y, Uchida K. Genetic polymorphism of pleiotrophin is associated with pain experience in Japanese adults: Case-control study. Medicine (Baltimore). 2022;16;101(37):e30580.
24. Suma S, Furuta M, Takeuchi K, Tomioka M, Iwasa Y, Yamashita Y. Number of teeth, denture wearing and cognitive function in relation to nutritional status in residents of nursing homes. Gerodontology. 2022;39(2):197-203.
25. Tamada Y, Takeuchi K, Okawa S, Tabuchi T. Secondhand Aerosol Exposure From Heated Tobacco Products and Its Socioeconomic Inequalities in Japan: The JASTIS Study 2017–2020. Nicotine Tobacco Res. 2022;24(9):1430-8.
26. Tamada Y, Yamaguchi C, Saito M, Ohira T, Shirai K, Kondo K, et al. Does laughing with others lower the risk of functional disability among older Japanese adults? The JAGES prospective cohort study. Prev Med. 2022;155:106945.
27. Wang Y, Shirai K, Ohira T, Hirosaki M, Kondo N, Takeuchi K, Yamaguchi C, Tamada Y, Kondo K, Cadar D, Iso H. Occasions for laughter and dementia risk: Findings from a six-year cohort study. Geriatr Gerontol Int. 2022;22(5):392-398.
28. Yamamoto-Kuramoto K, Kiuchi S, Kusama T, Kondo K, Takeuchi K, Osaka K, Aida J. Subjective cognitive complaints and dental clinic visits: A cross-sectional study from the Japan Gerontological Evaluation Study. Geriatrics & Gerontology International. 2022;22(9):773-8.
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1. Fujii R, Kondo T, Tsukamoto M, …, Takeuchi K, Wakai K. Association of self-reported moderate vegetable juice intake with small decline in kidney function in a five-year prospective study. Nutrition. 2021;84:111114.
2. Furuta M, Takeuchi K, Takeshita T, Shibata Y, Suma S, Kageyama S, Asakawa M, Hata J, Yoshida D, Shimazaki Y, Ninomiya T, Yamashita Y. 10-year trend of tooth loss and associated factors in a Japanese population-based longitudinal study. BMJ Open. 2021;11(8):e048114.
3. Hirosaki M, Ohira T, Shirai K, Kondo N, Aida J, Yamamoto T, Takeuchi K, Kondo K. Association between frequency of laughter and oral health among community-dwelling older adults: a population-based cross-sectional study in Japan. Qual Life Res. 2021;30:1561-1569.
4. Hishida A, Nakatochi M, Tamura T, …, Takeuchi K, Wakai K. Genome-wide association study of serum prostate-specific antigen levels based on 1000 Genomes imputed data in Japanese: the Japan Multi-Institutional Collaborative Cohort Study. Nagoya J Med Sci. 2021;83(1):183-194.
5. Igarashi A, Aida J, Kusama T, Tabuchi T, Tsuboya T, Sugiyama K, Yamamoto T, Osaka K. Heated Tobacco Products Have Reached Younger or More Affluent People in Japan. Journal of Epidemiology. 2021;31(3):187-93.
6. Iwase M, Matsuo K, Nakatochi M, …, Takeuchi K, Okada R, Kubo Y, Shimanoe C, Tanaka K, Ikezaki1 H, Murata M, Takezaki T, Nishimoto D, Kuriyama N, Ozaki E, Suzuki S, Watanabe M, Mikami H, Nakamura Y, Uemura H, Katsuura-Kamano S, Kuriki K, Kita Y, Naoyuki T, Nagino M, Momozawa Y, Kubo M, Wakai K. Differential effect of polymorphisms on body mass index across the life course of Japanese: the Japan Multi-Institutional Collaborative Cohort Study. J Epidemiol. 2021;31(3):172-179.
7. Katsuura-Kamano S, Arisawa K, Uemura H, …, Takeuchi K, Wakai K; Japan Multi-Institutional Collaborative Cohort J-MICC Study. Association of skipping breakfast and short sleep duration with the prevalence of metabolic syndrome in the general Japanese population: Baseline data from the Japan Multi-Institutional Collaborative cohort study. Prev Med Rep. 2021;24:101613.
8. Kawamura Y, Nakayama A, Shimizu S, …, Takeuchi K, Takada T, Tsunoda M, Arisawa K, Takezaki T, Tanaka K, Ichida K, Wakai K, Shinomiya N, Matsuo H. A Proposal for Practical Diagnosis of Renal Hypouricemia: Evidenced from Genetic Studies of Nonfunctional Variants of URAT1/SLC22A12 among 30,685 Japanese Individuals. Biomedicines. 2021;9(8):1012.
9. Kiuchi S, Cooray U, Kusama T, Yamamoto T, Abbas H, Nakazawa N, Kondo K, Osaka K, Aida J. Oral Status and Dementia Onset: Mediation of Nutritional and Social Factors. Journal of Dental Research. 2021;101(4):420-7.
10. Kiuchi S, Kusama T, Sugiyama K, Yamamoto T, Cooray U, Yamamoto T, Kondo K, Osaka K, Aida J. Longitudinal association between oral status and cognitive decline by fixed-effects analysis. Journal of Epidemiology. 2021;32(7):330-6.
11. Koyama T, Ozaki E, Kuriyama N, …, Takeuchi K, Wakai K. Effect of Underlying Cardiometabolic Diseases on the Association Between Sedentary Time and All-cause Mortality in a Large Japanese Population: A Cohort Analysis Based on the J-MICC Study. J Am Heart Assoc. 2021;10(13):e018293.
12. Koyama T, Takeuchi K, Tamada Y, Aida J, Koyama S, Matsuyama Y, Tabuchi T. Prolonged sedentary time under the state of emergency during the first wave of coronavirus disease 2019: assessing the impact of work environment in Japan. J Occup Health. 2021;63(1):e12260.
13. Kuroe K, Furuta M, Takeuchi K, Takeshita T, Suma S, Shinagawa T, Shimazaki Y, Yamashita Y. Association between periodontal condition and fibrotic progression of non-alcoholic fatty liver disease among Japanese adults. J Clin Periodontol. 2021;48(3):368-377.
14. Kusama T, Nakazawa N, Kiuchi S, Kondo K, Osaka K, Aida J. Dental prosthetic treatment reduced the risk of weight loss among older adults with tooth loss. Journal of the American Geriatrics Society. 2021;69(9):2498-2506.
15. Kusama T, Kiuchi S, Umehara N, Kondo K, Osaka K, Aida J. The Deterioration of Oral Function and Orofacial Appearance Mediated the Relationship between Tooth Loss and Depression among Community-dwelling Older Adults: A JAGES Cohort Study using Causal Mediation Analysis. Journal of Affective Disorders. 2021;286:174-179.
16. Matsuyama Y, Aida J, Takeuchi K, Koyama S, Tabuchi T. Dental pain and worsened socioeconomic conditions due to COVID-19 pandemic. J Dent Res. 2021;100(6):591-598.
17. Nakamura Y, Narita A, Sutoh Y, …, Takeuchi K, Kita Y, Wakai, K. A genome-wide Association Study on Meat Consumption in a Japanese Population- The Japan Multi-Institutional Collaborative Cohort study. J Nutr Sci. 2021;10:e61.
18. Ozeki S, Takeuchi K, Yasuoka M, Kamiji K, Kojima T, Waguri-Nagaya Y, Ojima T, Kondo K, Wakai K, Kojima M. Comparison of frailty associated factors between older adult patients with rheumatoid arthritis and community dwellers. Arch Gerontol Geriatr. 2021;96:104455.
19. 19. Takeshita T, Matsumoto K, Furuta M, Fukuyama S, Takeuchi K, Ogata H, Asakawa M, Kageyama S, Hata J, Ninomiya T, Inoue H, Yamashita Y. Airflow limitation and tongue microbiota in community-dwelling elderly individuals. ERJ Open Res. 2021;7(2):00616-2020.
20. Tamada Y, Takeuchi K, Yamaguchi C, Saito M, Ohira T, Shirai K, Kondo K. Does Laughter Predict Onset of Functional Disability and Mortality Among Older Japanese Adults? The JAGES Prospective Cohort Study. Journal of Epidemiology. 2021;31(5):301-7.
21. Toyoda Y, Kawamura Y, Nakayama A,…, Takeuchi K, Inoue I, Ichida K, Suzuki H, Shinomiya N, Takada T, Matsuo H. Substantial anti-gout effect conferred by common and rare variants of URAT1/SLC22A12. Rheumatology. 2021;60(11):5224-5232.
22. Usui Y, Matsuo K, Oze I,…, Takeuchi K, Tamura T, Tsukamoto M, Kadomatsu Y, Hara M, Nishida Y, Shimoshikiryo I, Takezaki T, Ozaki E, Matsui D, Watanabe I, Suzuki S, Watanabe M, Nakagawa-Senda H, Mikami H, Nakamura Y, Arisawa K, Uemura H, Kuriki K, Takashima N, Kadota A, Ikezaki H, Murata M, Nakatochi M, Momozawa Y, Kubo M, Wakai K. Impact of PSCA polymorphisms on the risk of duodenal ulcer. J Epidemiol. 2021;31(1):12-20.
23. Suzuki S, Goto A, Nakatochi M,…, Takeuchi K, Tanno K, Shimizu A, Tamiya G, Hozawa A, Kinoshita K, Wakai K, Sasaki M, Yamamoto M, Matsuo K, Tsugane S, Iwasaki M. Body mass index and colorectal cancer risk: a Mendelian randomization study. Cancer Sci. 2021;112(4):1579-1588.
24. Suzuki T, Nakamura Y, Doi Y,…, Takeuchi K, Kita Y, Wakai K. A Genome-wide Association Study on Confection Consumption in a Japanese Population – The Japan Multi-Institutional Collaborative Cohort Study. Br J Nutr. 2021;126(12):1843-1851.
25. Suzuki T, Nakamura Y, Matsuo K,…, Takeuchi K, Tamura T, Okada R, Kubo Y, Momozawa Y, Kubo M, Kita Y, Wakai K, for the J-MICC Research Group. A Genome-wide association study on fish consumption in a Japanese population – The Japan Multi-Institutional Collaborative Cohort Study: A conventional and a conditional analyses. Eur J Clin Nutr. 2021;75(3):480-488.
26. Suzuki H, Nakamura Y, Matsuo K,…, Takeuchi K, Wakai K, for the J-MICC Research Group. A genome-wide association study in Japanese identified one variant associated with a preference for a Japanese dietary pattern. Eur J Clin Nutr. 2021;75(6):937-945.
27. 相田潤, 草間太郎, 五十嵐彩夏, 小関健由, 小坂健, 人見早苗, 渡部千代. 歯科衛生士の離職防止と復職に関連する要因: ストレスモデルと歯科医師との意識の差. 口腔衛生学会雑誌. 2021;71(2):72-80.