Rehabilitation DentistryBiomaterials Science and Engineering
We are focusing on the fundamental science and the applied research of biomaterials and medical devices used especially for tissue engineering of various bone defects in the fields of dentistry, oral surgery, and an orthopedic surgery. Especially, we are developing new functional biomaterials and new devices based on biomimetics in terms of biomaterials science and biology.
Staff
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Prof. Osamu Suzuki,
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Associate Prof. Masahiro Okada,
Topics of Research
- Bone regeneration using the synthetic Octacalcium phosphate, which transforms into hydroxyapatite (HA) spontaneously when implanted in vivo.
- Device development of the controlled release of the growth factor which regenerate bone and periodontal tissue.
- Development of organic-inorganic composites by applying biomineralization.
- Evaluation of biomaterials by using 3D-cell culture devices which control the cell differentiation.
- Development of new dental materials and their evaluation system.
- Development of soft biological adhesives and their clinical application.
Recent Publications
- Suzuki O, Hamai R, Sakai S. The material design of octacalcium phosphate bone substitute: increased dissolution and osteogenecity. Acta Biomater 2023, in press. DOI: 10.1016/j.actbio.2022.12.046
- Xiao L, Shiwaku Y, Hamai R, Baba K, Tsuchiya K, Imazato S, Sasaki K, Suzuki O. Osteogenic capacity of octacalcium phosphate involving macrophage polarization. J Biomed Mater Res A 2022, in press. DOI: 10.1002/jbm.a.37484
- Hamada S, Mori Y, Shiwaku Y, Hamai R, Tsuchiya K, Baba K, Oizumi I, Kanabuchi R, Miyatake N, Aizawa T, Suzuki O. Octacalcium phosphate/gelatin composite (OCP/Gel) enhances bone repair in a critical-sized trans-cortical femoral defect rat model. Clin Orthop Relat Res 2022, 480:2043-2055. DOI: 10.1097/CORR.0000000000002257
- Okuyama K, Shiwaku Y, Hamai R, Mizoguchi T, Tsuchiya K, Takahashi T, Suzuki O. Differentiation of committed osteoblast progenitors by octacalcium phosphate compared to calcium-deficient hydroxyapatite in Lepr-cre/Tomato mouse tibia. Acta Biomater 2022, 142:332-344. DOI: 10.1016/j.actbio.2022.02.016
- Koyama S, Hamai R, Shiwaku Y, Kurobane T, Tsuchiya K, Takahashi T, Suzuki O. Angio-osteogenic capacity of octacalcium phosphate co-precipitated with copper gluconate in rat calvaria critical-sized defect. Sci Technol Adv Mater 2022, 23:120-139. DOI: 10.1080/14686996.2022.2035193 (Open Access)
- Hamai R, Sakai S, Shiwaku Y, Anada T, Tsuchiya K, Ishimoto T, Nakano T, Suzuki O. Octacalcium phosphate crystals including a higher density dislocation improve its materials osteogenecity. Appl Mater Today 2022, 26:101279. DOI: 10.1016/j.apmt.2021.101279 (Open Access) ※Press release
- Saito S, Hamai R, Shiwaku Y, Hasegawa T, Sakai S, Tsuchiya K, Sai Y, Iwama R, Amizuka N, Takahashi T, Suzuki O. Involvement of distant octacalcium phosphate scaffolds in enhancing early differentiation of osteocytes during bone regeneration. Acta Biomater 2021, 129:309-322. DOI: 10.1016/j.actbio.2021.05.017
- Ozaki H, Hamai R, Shiwaku Y, Sakai S, Tsuchiya K, Suzuki O. Mutual chemical effect of autograft and octacalcium phosphate implantation on enhancing intramembranous bone regeneration. Sci Technol Adv Mater 2021, 22:345-362. DOI: 10.1080/14686996.2021.1916378 (Open Access)
- Suzuki O, Shiwaku Y, Hamai R. Octacalcium phosphate bone substitute materials: Comparison between properties of biomaterials and other calcium phosphate materials. Dent Mater J 2020, 39:187-199. DOI: 10.4012/dmj.2020-001 (Open Access)
- Kawai T, Kamakura S, Matsui K, Fukuda M, Takano H, Iino M, Ishikawa S, Kawana H, Soma T, Imamura E, Kizu H, Michibata A, Asahisa I, Miuram K, Nakamura N, Kibe T, Suzuki O, Takahashi T. Clinical study of octacalcium phosphate and collagen composite in pral and maxillofacial surger. J Tissue Eng 2020, 11:1-15. DOI: 10.1177/2041731419896449 (Open Access)