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Craniofacial Anomalies


Our division is a clinical dentistry field specializing in research on the diagnosis and treatment of craniofacial anomalies, such as cleft lip and palate.

Including members from other departments in and outside our hospital, a special team performs treatment of abnormal occlusion and jaw deformities caused by congenital anomalies of craniofacial area such as cleft lip and palate.

The clinic of our department has been accredited by the Japanese Orthodontic Society as a training institute for orthodontists.

Faculty configuration

  • Kaoru IgarashiProf.Kaoru Igarashi

Topics of Research

  • Research on the diagnosis and treatment of craniofacial anomalies, such as cleft lip and palate
  • Research on the role of immune cells in osteoclastogenesis
  • Research on the effect of dietary habit on glycemic homeostasis
  • Development of a new anti-inflammatory bisphosphonate that also promote bone formation
  • Development of a new biocompatible shape memory alloy

Recent Performance

  1. Kanzaki H, Imai Y, Nakajo T, Daimaruya T, Sato A, Tachi M, Nunomura Y, Itagaki Y, Nishimura K, Kochi S, Igarashi K. Midfacial changes through anterior maxillary distraction osteogenesis in patients with cleft lip and palate. Journal of Craniofacial Surgery 2017;28(4):1057-1062.
  2. Tsuchiya S, Chiba M, Kishimoto KN, Nakamura H, Tsuchiya M, Hayashi H. Transfer of the bone morphogenetic protein 4 gene into rat periodontal ligament by in vivo electroporation. Archives of Oral Biology 2017;74:123-132.
  3. Takizawa A, Chiba M, Ota T, Yasuda M, Suzuki K, Kanemitsu T, Itoh T, Shinoda H, Igarashi K. The novel bisphosphonate disodium dihydrogen-4-[(methylthio)phenylthio] methanebisphosphonate increases bone mass in post-ovariectomy rats. Journal of Pharmacological Sciences 2016;131:37-50.
  4. Nunome S, Kanetaka H, Kudo T, Endoh K, Hosoda H, Igarashi K. In vitro evaluation of biocompatibility of Ti–Mo–Sn–Zr superelastic alloy. Journal of Biomaterials Applications 2015;30(1):119-130.
  5. Nishimura M, Sannohe M, Nagasaka H, Igarashi K, Sugawara J. Nonextraction treatment with temporary skeletal anchorage devices to correct a Class II division 2 malocclusion with excessive gingival display. American Journal of Orthodontics and Dentofacial Orthopedics 2014;145:85-94.

Laboratory Contacts

E-mail:igarashi*tohoku.ac.jp (Please change * to @.)