Community Social DentistryPediatric Dentistry

In the field of pediatric dentistry, we focus on general dental care in children in order to promote oral health.

In particular, we are in the process of identifying causative genes and understanding the pathogenic mechanism of diseases that cause morphological abnormalities of the teeth. We also work on control of the form and number of teeth in oral cavity through utilization of information gained through research and development of new tooth regeneration technology through application of stem cells (iPS cells).

Also, by using the previously discarded “milk teeth” as a cell source for regenerative medicine, we have developed a less invasive cell preparation method that we are introducing nationwide to help make regenerative dental care a reality. We also strive to improve the quality of dental carry treatment, the main goal of current pediatric dentistry, by developing and utilizing various materials which help in prevention and treatment of the disease. We closely monitor the current condition of cavities in local children to come up with new approaches to dietary education.


Topics of Research

  • Identification and functional analysis of disease genes related to the oral
  • Analysis of enamel and dentin formation
  • Research on differentiation mechanisms of ectodermal organs
  • Research on anti-tumor method by inducing calcification
  • Development of novel dental materials for calcification and anti-caries
  • Research on relationship between lifestyle and development in children

Recent Publications

  1. Tadano M, Matsunaga Y, Saito K, Suzuki Y, Nakamura T, Hoshikawa S, Chiba M, Hino R, Maruya Y, Fukumoto E, Yamada A, Fukumoto S. The correlation between the inner canthal distance and maxillary mesiodens in children. Pediatric Dental Journal, 33(2):125-132. 2023 doi: 10.1016/j.pdj.2023.04.001
  2. Miyata K, Chiba Y, Marchelina T, Inada S, Oka S, Saito K, Yamada A, Fukumoto S. Single-cell RNA-sequence of dental epithelium reveals responsible genes of dental anomalies in human. Pediatric Dental Journal, 33(2):102-115. 2023 doi: 10.1016/j.pdj.2023.03.004
  3. Chiba Y, Yoshizaki K, Sato H, Ikeuchi T, Rhodes C, Chiba M, Saito K, Nakamura T, Iwamoto T, Yamada A, Yamada Y, Fukumoto S. Deficiency of G-protein coupled receptor Gpr111/Adgrf2 causes enamel hypomineralization in mice by alteration of the expression of kallikrein-related peptidase 4 (Klk4) during pH cycling process. FASEB Journal, 37(4):e22861. 2023 doi: 10.1096/fj.202202053R
  4. Tadano M, Nakamura T, Hoshikawa S, Hino R, Maruya Y, Yamada Y, Fukumoto S, Saito K. The Retention Effect of Resin-Based Desensitizing Agents on Hypersensitivity—A Randomized Controlled Trial. Materials, 15(15):5172. 2022 doi:10.3390/ma15155172
  5. Iwata K, Kawarabayashi K, Yoshizaki K, Tian T, Saito K, Sugimoto A, Kurogoushi R, Yamada A, Yamamoto A, Kudo Y,Ishimaru N, Fukumoto S, Iwamoto T. von Willebrand factor D and EGF domains regulates ameloblast differentiation and enamel formation. Journal of cellular physiology, 237(3):1964-1979. 2022 doi:10.1002/jcp.30667
  6. Jia L, Chiba Y, Saito K, Yoshizaki K, Tian T, Han X, Mizuta K, Chiba M, Wang X, Al Thamin S, Yamada A, Fukumoto S. The tooth-specific basic-helix-loop-helix factor AmeloD promotes differentiation of ameloblasts. Journal of cellular physiology, 237(2):1597-1606. 2022 doi:10.1002/jcp.30639
  7. Chiba Y, Yoshizaki K, Tian T, Miyazaki K, Martin D, Saito K, Yamada A, Fukumoto S. Integration of single-cell RNA- and CAGE-seq reveals tooth-enriched genes. Journal of Dental Research, 101(5):220345211049785. 2022 doi:10.1177/00220345211049785
  8. Tadano M, Yamada A, Maruya Y, Hino R, Nakamura T, Hoshikawa S, Fukumoto S, Saito K. Evaluation of a Hypersensitivity Inhibitor Containing a Novel Monomer that Induces Remineralization – a case series in pediatric patients. Children, 8(12):1189. 2021 doi:10.3390/children8121189.

Laboratory Contacts