Tohoku University
Graduate School of Dentistry

Research

Joint Research DepartmentNext-Generation Dental Material Engineering

Joint Research Department of Next-Generation Dental Material Engineering has been established at 2011 by GC corporation with the aim to make healthy and long-lived society into reality through the research of dental equipment and materials which contributes greatly to oral health care. We are hoping to introduce and clinically apply the innovative technology which corresponds to the national survey regarding dental care, such as "painless treatment","highly aesthetic shape of the mouth" and "oral care of elderly".

To be more specific, we analyze the basic engineering possibilities of dental materials for regenerating missing teeth and bone defect. In addition we conduct research on the design, processing and biological safety of materials including their ability to function as intermediate materials.. We are also in the process of developing a mandatory test method to ascertain the long-term durability of the materials themselves in the oral environment so that they can continue to function and maintain their shape when used in vivo.

Our goal is the establishment of new dental diagnostic methods and testing equipment as well as introduction of new dental materials grounded in our novel clinical research and safety test.

Staff

  •  

    Prof. (Chair) Hiroshi Egusa,DDS, PhD, FRCPath

    researchmap

Topics of Research

  • Research on the development of next generation dental materials and their clinical application
  • Development of new evaluation methods for dental materials from the clinical viewpoint
  • Practicality and safety assessment of new dental materials
  • Consideration of an evaluation method incorporating clinical operations for dental materials
  • Evaluation of new dental diagnostic methods and testing equipment

Recent Publications

Thesis

  1. Clements A, Shibuya Y, Hokugo A, Brooks Z, Roca Y, Kondo T, Nishimura I, Jarrahy R. In vitro assessment of Neuronal PAS domain 2 mitigating compounds for scarless wound healing. Front Med (Lausanne). 9:1014763. 2023 Feb. doi: 10.3389/fmed.2022.1014763. eCollection 2022.
  2. Kondo T, Egusa H, Nishimura I. Current perspectives of residual ridge resorption: pathological activation of oral barrier osteoclasts. Journal of Prosthodontic Research. 67(1):12-22, 2023 Jan. doi: 10.2186/jpr.JPR_D_21_00333.
  3. Akashi Y, Nagasaki A, Okawa H, Matsumoto T, Kondo T, Hirofumi Y, Nishimura I, Egusa H. Cyclic pressure-induced cytokines from gingival fibroblasts stimulate osteoclast activity: clinical implications for alveolar bone loss in denture wearers. Journal of Prosthodontic Research. 67(1):77-86, 2023 Jan. doi: 10.2186/jpr.JPR_D_21_00238. 
  4. Kakinuma H, Izumita K, Yoda N, Egusa H, Sasaki K. Comparison of the accuracy of resin-composite crowns fabricated by three-dimensional printing and milling methods. Dental Materials Journal. 41(6):808-815. 2022 Nov. doi: 10.4012/dmj.2022-074.
  5. Kondo T†, Okawa H†, Hokugo A, Shokeen B, Sundberg O, Zeng Y, McKenna CE, Lux R, Nishimura I. († Contributed equally) Oral microbial extracellular DNA initiates periodontitis through gingival degradation by fibroblast-derived cathepsin K in mice. Communications Biology. 5: 962, 2022 Sep. doi: 10.1038/s42003-022-03896-7.
  6. Okawa H, Hokugo A, Sun S, Kondo T, Campagna JJ, John V, Ebetino FH, John V, McKenna CE, Nishimura I. Chemically inactivated Risedronate prevented the development of bisphosphonate-related osteonecrosis of the jaw (BRONJ) in mice. Communications Medicine. 2: 112, 2022 Sep. doi: 10.1038/s43856-022-00172-x. eCollection 2022.
  7. Shokeen B, Pham E, Esfandi J, Kondo T, Okawa H, Nishimura I, Lux R. Effect of calcium ion supplementation on oral microbial composition and biofilm formation in vitro. Microorganisms. 10: 10780, 2022 Sep. doi: 10.3390/microorganisms10091780.
  8. Okawa H†, Kondo T†, Hokugo A, Cerian P, Campagna JJ, Lentini N, Sun S, Sung EC, Chiang S, Lin Y, Ebetino FH, John V, McKenna CE, Nishimura I. († Contributed equally) Mechanism of bisphosphonate-related osteonecrosis of the jaw (BRONJ) revealed by targeted removal of legacy bisphosphonate from jawbone using equilibrium competing inert hydroxymethylene diphosphonate. eLife. 11:e76207, 2022 Aug. doi: 10.7554/eLife.76207.
  9. Zhang M, Niibe K, Kondo T, Limraksasin P, Okawa H, Miao X, Kamano Y, Yamada M, Jiang X, Egusa H. Rapid and efficient generation of cartilage pellets from mouse induced pluripotent stem cells by transcriptional activation of BMP-4 with shaking culture. Journal of Tissue Engineering. 13: 20417314221114616, 2022 Jul. doi: 10.1177/20417314221114616.
  10. Mayanagi G, Yufang L, Hoshino T, Takahashi N. A water-soluble glass-based temporary restorative resin inhibited bacteria-induced pH reductions at the bacteria-material interface. Dental Materials Journal. 41(1):95-100, 2022 Feb. doi:10.4012/dmj.2021-129.
  11. Yoda N, Abe Y, Suenaga Y, Matsudate Y, Hoshino T, Sugano T, Nakamura K, Okino A, Sasaki K. Resin cement–zirconia bond strengthening by exposure to low-temperature atmospheric pressure multi-gas plasma. Materials. 15:631, 2022 Jan. doi: 10.3390/ma15020631.
  12. Kitaoka A, Akatsuka R, Kato H, Yoda N, Sasaki K. Clinical Evaluation of Monolithic Zirconia Crowns: A Short-Term Pilot Report. The International Journal of Prosthodontics. 31(2): 124-126. 2018 Apr. doi: 10.11607/ijp.54444.

Conference Presentation

2022

  1. Fujimura K, Ambo S, Kondo T, Kakinuma H, Egusa H.
    Residual monomers from dual-cured resin cements due to light attenuation through zirconia induced inflammatory responses in vitro.
    Campus Asia Plus in Dentistry International Symposium 2023
    Sendai 2023/ 1/28-29
  2. Kakinuma H, Sasaki K.
    Bond strength to implant abutment materials and chemical polymerization property of self-adhesive resin cements.
    100th General Session & Exhibition of the IADR
    Virtual experience 2022/6/20-25

2021

  1. Kakinuma H, Sasaki K.
    Mechanical properties of hybrid resin blocks immersed in a water for one-year.
    99th General Session & Exhibition of the IADR
    Virtual experience 2021/7/21-24

2019

  1. Hoshino T, Matsudate Y, Sasaki K
    Wear resistance of CAD/CAM glass ceramic blocks
    98th GENERAL SESSION & EXHIBITION OF THE IADR
    U.S.A 2020/3/18-21
  2. Y. Abe, Y. Suenaga, M. Yoshida, Y. Matsudate, T. Hoshino, T. Sugano, N. Yoda, K. Sasaki, A. Okino
    Improvement of bond strength on dental materials using low temperature multi-gas plasma
    46th European Physical Society Conference on Plasma Physics (EPS 2019)
    Milan 2019/7/8-12
  3. Hoshino T, Matsudate Y, Sasaki K.
    Chemical durability of CAD/CAM glass-ceramic blocks
    97th General Session & Exhibition of the IADR
    Vancouver 2019/6/19-22

2018

  1. Hoshino T, Matsudate Y, Sasaki K.
    Physical Properties of CAD/CAM hybrid resin blocks after water immersion
    The 96th General Session & Exhibition of the IADR
    London 2018/7/25-28

2017

  1. Akiyama S, Akatsuka R, Sasaki K.
    Influence of cement thickness on dentin-adhesion of CAD/CAM nano-ceramic block
    The 95th General Session & Exhibition of the IADR
    Moscone West, San Francisco 2017/3/22-25

2016

  1. Akiyama S, Akatsuka R, Sasaki K.
    Wear Resistance Evaluation of Adhesive Resin Cement for Esthetic Restorations
    The 94th General Session & Exhibition of the IADR
    CoEX Convention & Exhibition Center
    Seoul 2016/6/22-25
  2. Izumita K, Akatsuka R, Tomie A, Kuji C, Kuriyagawa T, Sasaki K. Development of Powder Jet Deposition Technique and New Treatment for Discolored Teeth
    Interface Oral Health Science 2016 Innovative Research on Biosis-Abiosis Intelligent Interface
    Japan 2016/1/18-19

2015

  1. Akiyama S, Fujimi A, Fukushima S, Kumagai T, Sasaki K.
    Influence of cement film thickness on cyclic loading to CAD/CAM composite blocks
    HKU-Tohoku University 1st Bilateral Dental Symposium
    Prince Philip Dental Hospital Hong Kong 2015/10/16
  2. Akiyama S, Akatsuka R, Sasaki K.
    Evaluation of Gloss-retention and Self-polishing Property of CAD/CAM CompositeBlock
    The 93rd General Session & Exhibition of the IADR
    Hynes Convention Center Boston 2015/3/11-14

2013

  1. Sato N, Koyama S, Fukushima S, Sasaki K.
    Material property of cohesive silicone for the denture
    15th Biennial Meeting of the International College of Prosthodontists
    Lingotto Congress Center Torino Italy 2013/9/18-21
  2. Takeuchi Y, Fukushima S, Washio J, Ishiguro K, Takahashi N, Sasaki K.
    The bending strength and surface property of a soft acrylic resin for denture material in comparison with conventional denture materials
    15th Biennial Meeting of the International College of Prosthodontists
    Lingotto Congress Center Torino Italy 2013/9/18-21
  3. Fukushima S, Akatsuka R, Sasaki K.
    Influence of surface treatment of Lithium disilicate glass-ceramics on TBS
    The 91th General Session & Exhibition of the IADR Washington State Convention Center Seattle 2013/3/20-23
  4. Fukushima S, Akatsuka R, Sasaki K.
    Bond Durability of Self-Adhesive Resin Cement to CAD/CAM Restorative materials
    American Association for Dental Research (AADR) ANNUAL MEETING
    CHARLOTTE Convention Center
    CHARLOTTE 2014/3/19-22

2012

  1. Fukushima S, Akatsuka R, Sasaki K.
    Effect of mixing methods on the physical properties of glass ionomer cements
    American Association for Dental Research (AADR) ANNUAL MEETING
    Tampa Convention Center Tampa 2012/3/21-24
  2. Akatsuka R, Fukushima S, Sasaki K.
    Effect of mixing methods on the bonding strength of glass ionomer cements
    American Association for Dental Research (AADR) ANNUAL MEETING
    Tampa Convention Center Tampa 2012/3/21-24

Laboratory Contacts

@
+81-22-717-8433

Research