Tohoku University
Graduate School of Dentistry

Research

Joint Research DepartmentNext-Generation Dental Material Engineering

Joint Research Department of Next-Generation Dental Material Engineering has been established at 2011 by GC corporation with the aim to make healthy and long-lived society into reality through the research of dental equipment and materials which contributes greatly to oral health care. We are hoping to introduce and clinically apply the innovative technology which corresponds to the national survey regarding dental care, such as "painless treatment","highly aesthetic shape of the mouth" and "oral care of elderly".

To be more specific, we analyze the basic engineering possibilities of dental materials for regenerating missing teeth and bone defect. In addition we conduct research on the design, processing and biological safety of materials including their ability to function as intermediate materials.. We are also in the process of developing a mandatory test method to ascertain the long-term durability of the materials themselves in the oral environment so that they can continue to function and maintain their shape when used in vivo.

Our goal is the establishment of new dental diagnostic methods and testing equipment as well as introduction of new dental materials grounded in our novel clinical research and safety test.

Staff

Topics of Research

  • Research on the development of next generation dental materials and their clinical application
  • Development of new evaluation methods for dental materials from the clinical viewpoint
  • Practicality and safety assessment of new dental materials
  • Consideration of an evaluation method incorporating clinical operations for dental materials
  • Evaluation of new dental diagnostic methods and testing equipment

Recent Publications

Thesis

Research articles

  1. Kondo T, Thaweesapphithak S, Ambo S, Otake K, Ohori-Morita Y, Mori S, Vinaikosol N, Porntaveetus T, Egusa H. Fabrication of hard tissue constructs from induced pluripotent stem cells for exploring mechanisms of hereditary tooth/skeletal dysplasia. International Journal of Molecular Sciences. 26(2): 804, 2025 Jan.　doi: org/10.3390/ijms26020804
  2. Kondo T, Kakinuma H, Ambo S, Otake K, Sato Y, Egusa H. Influence of dual-cure resin-cement curing mode on gingival cytotoxicity and inflammatory responses. Journal of Dental Sciences. 20(1): 586-595, 2025 Jan. doi: 10.1016/j.jds.2024.04.019.
  3. Kondo T, Yamada M, Egusa H. Innate immune regulation in dental implant osseointegration. Journal of Prosthodontic Research. 68(4): 511-521, 2024 Oct. doi: 10.2186/jpr.JPR_D_23_00198.
  4. Tran HT, Kondo T, Ashry A, Fu Y, Okawa H, Sawangmake C, Egusa H. Effect of circadian clock disruption on type 2 diabetes. Frontiers in Physiology. 15: 1435848, 2024 Aug. doi: 10.3389/fphys.2024.1435848.
  5. Kondo T, Otake K, Kakinuma H, Sato Y, Ambo S, Egusa H. Zinc- and fluoride-releasing bioactive glass as a novel bone substitute. Journal of Dental Research. 105(5): 526-535, 2024 Apr. doi: 10.1177/00220345241231772.
  6. Kakinuma H, Koyama S, Kondo T, Harata T, Egusa H. In vitro evaluation of shape-memory hydrogels for removable dental prostheses and optimization of phase-transition temperature for intraoral use. Journal of Prosthetic Dentistry. 131(4): 708.e1-708.e8, 2024 Apr. doi: 10.1016/j.prosdent.2024.01.016.
  7. Kondo T. A case of esthetic improvement by occlusal reconstruction in a patient with decreased occlusal vertical dimension due to tooth wear. Annals of Japan Prosthodontic Society. 16(1): 143-146, 2024 Jan. doi: 10.2186/ajps.16.143.
  8. Kondo T, Gleason A, Okawa H, Hokugo A, Nishimura I. Mouse gingival single-cell transcriptomic atlas identified a novel fibroblast subpopulation activated to guide oral barrier immunity in periodontitis. eLife. 12: RP88183, 2023 Nov. doi: 10.7554/eLife.88183.
  9. Kondo T, Kakinuma H, Fujimura K, Ambo S, Otake K, Sato Y, Egusa H. Incomplete polymerization of dual-cured resin cement due to attenuated light through zirconia induces inflammatory responses. International Journal of Molecular Sciences. 24(12): 9861, 2023 Jun. doi: 10.3390/ijms24129861.
  10. Kondo T. A novel risk diagnosis of periodontitis by evaluation of patient plaque-derived extracellular DNA. Journal of the Japanese Association for Dental Science. 42: 74, 2023 Mar.
  11. Clements A, Shibuya Y, Hokugo A, Brooks Z, Roca Y, Kondo T, Nishimura I, Jarrahy R. In vitro assessment of Neuronal PAS domain 2 mitigating compounds for scarless wound healing. Frontiers in Medicine (Lausanne). 9: 1014763. 2023 Feb. doi: 10.3389/fmed.2022.1014763. eCollection 2022.
  12. Kondo T, Kanayama K, Egusa H, Nishimura I. Current perspectives of residual ridge resorption: Pathological activation of oral barrier osteoclasts. Journal of Prosthodontic Research. 67(1): 12-22, 2023 Jan. doi: 10.2186/jpr.JPR_D_21_00333.
  13. Akashi Y, Nagasaki A, Okawa H, Matsumoto T, Kondo T, Hirofumi Y, Nishimura I, Egusa H. Cyclic pressure-induced cytokines from gingival fibroblasts stimulate osteoclast activity: clinical implications for alveolar bone loss in denture wearers. Journal of Prosthodontic Research. 67(1): 77-86, 2023 Jan. doi: 10.2186/jpr.JPR_D_21_00238.
  14. Kakinuma H, Izumita K, Yoda N, Egusa H, Sasaki K. Comparison of the accuracy of resin-composite crowns fabricated by three-dimensional printing and milling methods. Dental Materials Journal. 41(6): 808-815. 2022 Nov. doi: 10.4012/dmj.2022-074.
  15. Kondo T, Okawa H, Hokugo A, Shokeen B, Sundberg O, Zeng Y, McKenna CE, Lux R, Nishimura I. Oral microbial extracellular DNA initiates periodontitis through gingival degradation by fibroblast-derived cathepsin K in mice. Communications Biology. 5: 962, 2022 Sep. doi: 10.1038/s42003-022-03896-7.
  16. Okawa H, Kondo T, Hokugo A, Cherian P, Sundberg O, Campagna JJ, Kashemirov BA, John V, Sun S, Ebetino FH, McKenna CE, Nishimura I. Fluorescent risedronate analogue 800CW-pRIS improves tooth extraction-associated abnormal wound healing in zoledronate-treated mice. Communications Medicine. 2: 112, 2022 Sep. doi: 10.1038/s43856-022-00172-x. eCollection 2022.
  17. Shokeen B, Pham E, Esfandi J, Kondo T, Okawa H, Nishimura I, Lux R. Effect of calcium ion supplementation on oral microbial composition and biofilm formation in vitro. Microorganisms. 10: 10780, 2022 Sep. doi: 10.3390/microorganisms10091780.
  18. Okawa H†, Kondo T†, Hokugo A, Cherian P, Campagna JJ, Lentini N, Sung EC, Chiang S, Lin Y, Ebetino FH, John V, Sun S, McKenna CE, Nishimura I. († Contributed equally) Mechanism of bisphosphonate-related osteonecrosis of the jaw (BRONJ) revealed by targeted removal of legacy bisphosphonate from jawbone using equilibrium competing inert hydroxymethylene diphosphonate. eLife. 11: e76207, 2022 Aug. doi: 10.7554/eLife.76207.
  19. Zhang M, Niibe K, Kondo T, Limraksasin P, Okawa H, Miao X, Kamano Y, Yamada M, Jiang X, Egusa H. Rapid and efficient generation of cartilage pellets from mouse induced pluripotent stem cells by transcriptional activation of BMP-4 with shaking culture. Journal of Tissue Engineering. 13: 20417314221114616, 2022 Jul. doi: 10.1177/20417314221114616.
  20. Mayanagi G, Yufang L, Hoshino T, Takahashi N. A water-soluble glass-based temporary restorative resin inhibited bacteria-induced pH reductions at the bacteria-material interface. Dental Materials Journal. 41(1): 95-100, 2022 Feb. doi: 10.4012/dmj.2021-129.
  21. Yoda N, Abe Y, Suenaga Y, Matsudate Y, Hoshino T, Sugano T, Nakamura K, Okino A, Sasaki K. Resin cement–zirconia bond strengthening by exposure to low-temperature atmospheric pressure multi-gas plasma. Materials. 15: 631, 2022 Jan. doi: 10.3390/ma15020631.
  22. Harada T, Koyama S, Hoshino T, Izumita K, Kato H, Sato N, Kawakami M, Hurukawa H, Sasaki K. Evaluation of the physical properties of shape memory hydrogel for dental application. Maxillofacial Prosthetics. 44(2): 48-57 2021 Dec. doi: 10.34333/jamp.44.2_48.
  23. Kitaoka A, Akatsuka R, Kato H, Yoda N, Sasaki K. Clinical evaluation of monolithic zirconia crowns: a short-term pilot report. The International Journal of Prosthodontics. 31(2): 124-126. 2018 Apr. doi: 10.11607/ijp.54444.
  24. Mizutani M, Kuji C, Ohisa H, Nishimura S, Mizutani K, Akatsuka R, Sasaki K, Xu S, Shimada K, Kuriyagawa T. Particle fracture behavior and deposition mechanism in powder jet deposition (PJD). Journal of the Japan Society of Grinding Engineers. 61(1): 28-33. 2017 Jan. doi: 10.11420/jsat.61.28.
  25. Koyama S, Fukushima S, Sasaki K. Recovery from deformation and elongation of new silicone material for facial prostheses. Maxillofacial Prosthetics. 37(1): 15-19 2014 Jun. doi: 10.34333/jamp.37.1_15.

Other publications

  1. Kondo T, Ambo S, Egusa H, Nishimura I.
    A dental plaque-derived extracellular DNA drives periodontitis.
    Medical Science Digest Vol.50 (4) 48-51, 2024.
    The New Science Co., Ltd.
  2. Kondo T.
    A winner's voice of oral presentation competition of biology in the 132nd Annual Meeting of the Japan Prosthodontic Society.
    Letter for Members by Japanese Prosthodontic Society. 73: 21-22, 2023.
    Japanese Association for Dental Research
  3. Kondo T.
    A report of the 101th General Session & Exhibition of the IADR.
    Newsletter for JADR. 2: 5, 2023.
    Japanese Association for Dental Research
  4. Kondo T.
    Research and clinical work in America during the coronavirus pandemic.
    Dental Outlook. 139(4): 766-772, 2022.
    Ishiyaku Pubishers Inc.

Awards

  1. Kondo T. Tohoku University Dental Society Research Encouragement Award. 2024/12/13
  2. Sato Y, Kondo T, Egusa H. Japanese Association for Dental, Oral, and Craniofacial Research（JADR） GC Young Investigator Award. 2024/11/16
  3. Kondo T, Egusa H. Japan Prosthodontic Society Dentsply Sirona Award. 2024/7/7
  4. Kakinuma H, Koyama S, Egusa H, Yoda N. Japan Prosthodontic Society Dentsply Sirona Award. 2024/7/7
  5. Kondo T, Nishimura I, Egusa H. Japan Prosthodontic Society 1st place in oral presentation competition of Biology. 2023/5/21
  6. Lee C, Kondo T, Okawa H, Hokugo A, Hamada Y, Nishimura I. California Society of Periodontists Research Award. 2023/3/4

Conference presentation

2024

  1. Kondo T.
    Oral membrane regulates alveolar bone metabolism
    The 84th Tohoku University Dental Society
    Sendai，2024/12/13
  2. Sato Y, Kondo T, Egusa H.
    Innate Lymphoid Cells Promote Alveolar Bone Formation
    The 72nd Annual Meeting of Japanese Association for Dental, Oral, and Craniofacial Research
    Kagoshima, 2024/11/16-17
  3. Kondo T.
    Single-cell analysis for prosthodontic research
    The 133rd Annual Meeting of the Japan Prosthodontic Society
    Chiba 2024/7/5-7
  4. Kondo T, Egusa H.
    Fabrication of in vitro hard tissue constructs from human induced pluripotent stem cells towards elucidation of mechanisms of odontogenesis/osteogenesis imperfecta
    The 133rd Annual Meeting of the Japan Prosthodontic Society
    Chiba 2024/7/5-7
  5. Kakinuma H, Koyama S, Egusa H, Yoda N.
    Development of 3D Printing Shape Memory Hydrogels for Maxillofacial Prosthesis
    The 133rd Annual Meeting of the Japan Prosthodontic Society
    Chiba 2024/7/5-7
  6. Kondo T.
    Elucidation of the regulation mechanism of tooth extraction socket healing by immune cells
    The 2nd Research Association for Organ Regeneration/Stem Cells
    Okayama 2024/5/25-26

2023

  1. Otake K, Kondo T, Kakinuma H, Sato Y, Ambo S, Egusa H.
    Zn- and F- Releasing Bioactive Glass as a Novel Bone Substitute
    The 101th General Session & Exhibition of the IADR
    Bogota 2023/6/21-24
  2. Kondo T, Nishimura I, Egusa H.
    Newly identified gingival fibroblast subpopulation regulate oral barrier tissue immunity
    The 132nd Annual Meeting of the Japan Prosthodontic Society
    Yokohama 2023/5/19-21
  3. Kakinuma H, Koyama S, Egusa H.
    Characterization of Shape Memory Hydrogels for Prosthetic Dental Material
    The 132nd Annual Meeting of the Japan Prosthodontic Society
    Yokohama 2023/5/19-21
  4. Lee C, Kondo T, Okawa H, Hokugo A, Hamada Y, Nishimura I.
    An Investigation of the Role of Npas2 in Alveolar Bone Regeneration in the Mouse Periodontitis Model
    CSP Perio-Hygiene Collaborative Carlsbad
    California 2023/3/4

2022

  1. Fujimura K, Ambo S, Kondo T, Kakinuma H, Egusa H. Residual monomers from dual-cured resin cements due to light attenuation through zirconia induced inflammatory responses in vitro
    Campus Asia Plus in Dentistry International Symposium 2023
    Sendai 2023/1/28-29
  2. Kondo T, Egusa H.
    A novel risk diagnosis of periodontitis by evaluation of patient plaque-derived extracellular DNA
    The 38th Meeting for Promotion of Comprehensive Research by Japanese Association for Dental Science
    Tokyo 2023/1/20
  3. Kondo T.
    Next-generation prosthodontic treatment using online communication
    The 40th Annual Meeting of the Academy of Clinical Dentistry
    Web 2022/11/1-24
  4. Kakinuma H, Sasaki K.
    Bond strength to implant abutment materials and chemical polymerization property of self-adhesive resin cements
    The 100th General Session & Exhibition of the IADR
    Virtual experience 2022/6/20-25

2021

  1. Kakinuma H, Sasaki K.
    Mechanical properties of hybrid resin blocks immersed in a water for one-year
    The 99th General Session & Exhibition of the IADR
    Virtual experience 2021/7/21-24

2019

  1. Hoshino T, Matsudate Y, Sasaki K.
    Wear resistance of CAD/CAM glass ceramic blocks
    The 98th General Session & Exhibition of the IADR
    U.S.A 2020/3/18-21
  2. Yoda N, Abe Y, Mastsudate Y, Hoshino T, Sugano T, Suenaga Y, Yoshida M, Hong G, Okino A, Sasaki K.
    Effect of low temperature multi-gas plasma on improvement of bond strength on dental materials
    The 4th International Symposium on Biomedical Engineering
    Shizuoka 2019/11/14-15
  3. Abe Y, Suenaga Y, Hoshino T, Matsudate Y, Sugano T, Yoda N, Okino A, Sasaki K.
    Examination of atmospheric plasma treatment conditions for bonding strength improvement of dental materials
    The 80th JSAP Autumn Meeting
    Hokkaido 2019/9/18-21
  4. Y. Abe, Y. Suenaga, M. Yoshida, Y. Matsudate, T. Hoshino, T. Sugano, N. Yoda, K. Sasaki, A. Okino
    Improvement of bond strength on dental materials using low temperature multi-gas plasma
    The 46th European Physical Society Conference on Plasma Physics (EPS 2019)
    Milan 2019/7/8-12
  5. Hoshino T, Matsudate Y, Sasaki K.
    Chemical durability of CAD/CAM glass-ceramic blocks
    The 97th General Session & Exhibition of the IADR
    Vancouver 2019/6/19-22
  6. Abe Y, Suenaga Y, Hoshino T, Matsudate Y, Sugano T, Yoda N, Sasaki K, Okino A.
    Spectroscopic measurement of surface condition for improving adhesion strength of zirconia by atmospheric pressure plasma treatment
    The Annual Meeting of the Spectroscopical Society of Japan 2019
    Kyoto 2019/5/14-16
  7. Matsudate Y, Yoda N, Hoshino T, Sugano T, Abe Y, Suenaga Y, Okino A, Sasaki K.
    Effect of gas species used for atmospheric plasma surface treatment on the surface of dental zirconia
    The 128th Annual Meeting of the Japan Prosthodontic Society
    Hokkaido 2019/5/10-12/

2018

  1. Hoshino T, Matsudate Y, Sasaki K.
    Physical properties of CAD/CAM hybrid resin blocks after water immersion
    The 96th General Session & Exhibition of the IADR
    London 2018/7/25-28

2017

  1. Akiyama S, Akatsuka R, Sasaki K.
    Influence of cement thickness on dentin-adhesion of CAD/CAM nano-ceramic block
    The 95th General Session & Exhibition of the IADR
    San Francisco 2017/3/22-25

2016

  1. Akatsyka R.
    Development and practical application of medical device for dental treatment without re-treatment
    The Autum Symposium of the Japan Society for Precision Engineering 2016
    Ibaraki 2016/9/5-7
  2. Akiyama S, Akatsuka R, Sasaki K.
    Wear resistance evaluation of adhesive resin cement for esthetic restorations
    The 94th General Session & Exhibition of the IADR
    Seoul 2016/6/22-25
  3. Hirama M, Michii T, Akiyama S, Shigemitsu R, Abe J, Orii Y, Sasaki K. Development of the method to fabricate CAD/CAM complete denture using tooth arrangement template
    The 7th Scientific Meeting of the Japan Academy of Digital Dentistry
    Hokkaido 2016/5/28-29
  4. Izumita K, Akatsuka R, Tomie A, Kuji C, Kuriyagawa T, Sasaki K.
    Development of powder jet deposition technique and new treatment for discolored teeth
    Interface Oral Health Science 2016 Innovative Research on Biosis-Abiosis Intelligent Interface
    Japan 2016/1/18-19

2015

  1. Akiyama S, Fujimi A, Fukushima S, Kumagai T, Sasaki K.
    Influence of cement film thickness on cyclic loading to CAD/CAM composite blocks
    HKU-Tohoku University 1st Bilateral Dental Symposium
    Hong Kong 2015/10/16
  2. Akiyama S, Akatsuka R, Sasaki K.
    Evaluation of gloss-retention and self-polishing property of CAD/CAM composite block
    The 93rd General Session & Exhibition of the IADR
    Boston 2015/3/11-14

2014

  1. Koyama S, Fukushima S, Sasaki K.
    Recovery from deformation and elongation of new silicone material for facial prostheses
    The 31th Annual Meeting of Japanese Academy of Maxillofacial Prosthetics
    Sendai 2014/6/20-22
  2. Michii T, Kumagai T, Yamamoto S, Iwaki M, Kanazawa M, Minakuchi S, Orii Y, Fukushima S, Abe J, Sasaki K.
    Physical properties of resin discs in CAD/CAM denture systems
    The 123th Annual Meeting of the Japan Prosthodontic Society
    Sendai 2014/5/24-25
  3. Orii Y, Takeuchi H, Michii T, Fukushima S, Ishiguro K, Abe J, Kumagai T, Sasaki K.
    Evaluation of the S. mutans attachment to acrylic resin for complete denture
    The 123th Annual Meeting of the Japan Prosthodontic Society
    Sendai 2014/5/24-25
  4. Fukushima S, Akatsuka R, Sasaki K.
    Effects of thermal shock and acid immersion on degradation of CAD/CAM blocks
    The 123th Annual Meeting of the Japan Prosthodontic Society
    Sendai 2014/5/24-25
  5. Fukushima S, Akatsuka R, Sasaki K.
    Bond durability of self-adhesive resin cement to CAD/CAM restorative materials
    American Association for Dental Research (AADR) 2014 Annual Meeting
    Charlotte 2014/3/19-22

2013

  1. Ishiguro K, Washio J, Sakuma Y, Takeuchi H, Fukushima S, Sasaki K, Takahashi N.
    Evaluation of attachment of the periodontitis-related bacteria to the surface of denture resin (PMMA)
    The 55th Annual Meeting of Japanese Association for Oral Biology
    Okayama 2013/9/21-22
  2. Sato N, Koyama S, Fukushima S, Sasaki K.
    Material property of cohesive silicone for the denture
    15th Biennial Meeting of the International College of Prosthodontists
    Italy 2013/9/18-21
  3. Takeuchi Y, Fukushima S, Washio J, Ishiguro K, Takahashi N, Sasaki K.
    The bending strength and surface property of a soft acrylic resin for denture material in comparison with conventional denture materials
    15th Biennial Meeting of the International College of Prosthodontists
    Italy 2013/9/18-21
  4. Koyama S, Fukushima S, Sasaki K.
    Recovery from deformation and elongation of new silicone material for facial prostheses
    The 30th Annual Meeting of Japanese Academy of Maxillofacial Prosthetics
    Koriyama 2013/6/20-22
  5. Orii Y, Michii T, Fukushima S, Abe J, Kanazawa M, Kumagai T, Minakuchi S, Sasaki K.
    Fabrication of complete denture using CAD/CAM and wax resin
    The 122th Annual Meeting of the Japan Prosthodontic Society
    Fukuoka 2013/5/18-19
  6. Fukushima S, Akatsuka R, Sasaki K.
    Influence of surface treatment of Lithium disilicate glass-ceramics on TBS
    The 91th General Session & Exhibition of the IADR
    Seattle 2013/3/20-23

2012

  1. Fukushima S, Sasaki K.
    Physicochemical properties of glass-fiber-reinforced composite resins
    The 60th General Session of the Japanese Society for Dental Materials and Devices
    Fukuoka 2012/10/13-14
  2. Fukushima S, Akatsuka R, Sasaki K.
    Effect of mixing methods on the physical properties of glass ionomer cements
    American Association for Dental Research (AADR) 2012 Annual Meeting
    Tampa 2012/3/21-24
  3. Akatsuka R, Fukushima S, Sasaki K.
    Effect of mixing methods on the bonding strength of glass ionomer cements
    American Association for Dental Research (AADR) 2012 Annual Meeting
    Tampa 2012/3/21-24

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Research