Innovative Liaison DentistryInternational Collaborative and Innovative Dentistry

Our major research is focus on development and applied research of functional biomaterials and digital transformation in health care and educational settings based on the international industry-academia/interdisciplinary collaboration to improve oral health related QOL.


  • Assist. Prof. Juan Ramón Vanegas Sáenz,

Topics of Research

  • Development of functional biomaterials
  • Rheology of biopolymer materials
  • Development of metal free dental implant materials
  • Establishment of the International Standard of dental materials
  • Research and development on digital transformation in healthcare and educational settings

Recent Publications

  1. Han Y., Xing X., Zhou L., Huang S., Lin Z., Hong G., Chen J. GL13K-modified titanium regulates osteogenic differentiation via the NF-κB pathway. Int Immunopharmacology 2024; 11: 111279.
  2. Nugraha A.P., Yang H., Chen J., Yang K., Kraisintu P., Zaww K., Ma A., Wang R., Alhadi N.E.A.M., Vanegas Sáenz J.R., Hong G. β-Tricalcium Phosphate as Alveolar Bone Grafting in Cleft Lip/Palate: A Systematic Review. Dent J 2023; 11: 234.
  3. Zhang Y.-D., Ma A.-B., Sun L., Chen J.-D., Hong G., Wu H.-K. Nanoclay-Modified Hyaluronic Acid Microspheres for Bone Induction by Sustained rhBMP-2 Delivery. Macromol Biosci 2023 (in-press).
  4. Hong G*, Hung CC, Mayanagi G, Nishioka T, Sun L, Lai HH Eddie, Lan TH, Sasaki K, Takahashi N. Questionnaire survey on the satisfaction of SimEx dental education system. J Dent Sci 2023; 18: 840-847.
  5. J Sun, N Yoda, Y Matsudate, G Hong, T Kawata, K Sasaki. Effect of Different Retightening Procedures on Screw Stability in External-hex and Internal Tri-channel Connections: An In Vitro Study. Int J Prosthodont, 2023; 36: 181-188.
  6. Luo, Y.-R.; Kudo, T.-a.; Tominami, K.; Izumi, S.; Tanaka, T.; Hayashi, Y.; Noguchi, T.; Matsuzawa, A.; Nakai, J.; Hong, G.; Wang, H.: SP600125 Enhances Temperature-Controlled Repeated Thermal Stimulation-Induced Neurite Outgrowth in PC12-P1F1 Cells. Int J Mol Sci 2022; 23: 15602.
  7. A. Corrales Zuniga, N.L. Sauceda Malespin, A.L. Vega Vilchez, O.J. Duarte Frenky, G. Hong, J.R. Vanegas Saenz. Evaluation of the ergonomic sitting position adopted by dental students while using dental simulators. J Dent Sci 2022; 18: 526-533.
  8. F Luo, R Li, H Zheng, Y Xu, L Yang, C Qu, G Hong*, Q Wan*. Differentiation of bone mesenchymal stem cell into vascular endothelial cell-like cell using functionalized single-walled carbon nanotubes. Front Bioeng Biotechnol 2022; 10: 913080.
  9. C Qu, F Luo. G Hong, Q Wan*. Performance of deep learning methods for the identification of dental implants: a systematic review and meta-analysis. Diagnostics, 2022 (accepted).
  10. C Qu, F Luo, G Hong, Q Wan*. Effect of photobiomodulation therapy on implant stability and postoperative recovery: a systematic review and meta-analysis. Br J Oral Maxillofac Surg 2022; 60: 712-721.
  11. Narita, K.; Kudo, TA.; Hong, G.; Tominami, K.; Izumi, S.; Hayashi, Y.; Nakai, J. Effect of Beta 2-Adrenergic Receptor Gly16Arg Polymorphism on Taste Preferences in Healthy Young Japanese Adults. Nutrients 2022; 14: 1430.
  12. G Hong*, JK-H Tsoi, JM Han. Editorial: Biofunctional Applications of Zirconia in Dental Devices. Front Dent Med 2022; 3: 841120.
  13. T Takano, K Takashima, K Fujita, G Hong, K Ikematsu, Y Kitamura. A compact and low-cost VR tooth drill training system using mobile HMD and stylus smartphone. VRST 2021; 46: 3.
  14. YD Zhang, YF Zhang, HK Wu*, G Hong. Application of Hyaluronic Acid as a Biopolymer Materials in Reconstruction of Interdental Papilla in Rats. Front Mater 2021; 8: 798391.
  15. CX Qu, F Luo*, G Hong, QB Wan. Effects of platelet concentrates on implant stability and marginal bone loss: a systematic review and meta-analysis. BMC Oral Health, 2021; 21: 579.
  16. Kuntjoro M, Hendrijantini N, Rantam FA, Hong G, Salim S, Ari MDA. Osteoclast activity in osteoporosis mandibular bone based on RAKL and osteoprotegerin ratio. J Pharm Pahrmacogn Res 2021; 9: 870-877.
  17. TY Chang, ML Hsu, JS Kwon, MLS Kusdhany, G Hong*. Effect of online learning for dental education in Asia during the pandemic of COVID-19. J Dent Sci 2021; 16: 1095-1101.
  18. L Sun, G Hong*. Surface Modifications for Zirconia Dental Implants: A Review. Front Dent Med, 2021; 2: 733242.
  19. Luo F, Hong G, Wan Q. Artificial Intelligence in Biomedical Applications of Zirconia. Front Dent Med, 2021; 2: 689288.
  20. T Nishioka, G Mayanagi, Y Iwamatsu-Kobayashi, G Hong*: Impact of the COVID-19 pandemic on dental clinical training and future prospects. J Dent Educ, 2021; 85(Suppl. 3), 1999-2001.
  21. H Kashiwada, Y Shimizu*, Y Sano, K Yamauchi, G Hong, H Kumamoto, H Unuma, YJ Zhu: In vivo behaviors of Highly flexible paper consisting of ultralong hydroxyapatite nanowires. J Boimed Mater Res B Appl Biomater 2021; 109: 1611-1621.
  22. H Lin, CL Yin, AC Mo*, G Hong: Applications of hydrogel with special physical properties in bone and cartilage regeneration. Materials 2021; 14: 235.
  23. Y Ito*, G Hong, A Tsuboi, Y Kawai, H Kondo, et al. Multivariate analysis reveals oral health-related quality of life of complete denture wearers with denture adhesives: A multicenter randomized controlled trial. J Prosthodont Res 2021; 65: 353-359.
  24. Y Yamazaki, T Ito, T Ogawa, G Hong, Y Yamada, T Hamada, K Sasaki. Potential of pure cellulose nanofibers as a denture base material. J Oral Sci 2021; 63: 111-113.
  25. G Hong, TY Chang, A Terry, S Chuenjitwongsa, YS Park, James KH Tsoi, M.F. Lindawati S. Kusdhany, H Egusa, S Yamada, JS Kwon, LL Seow, Ma. Cristina Aurea G. Garcia, WM Loke, P Auychai, Allen ML Hsu*: Guidelines for innovation in dental education during the coronavirus disease 2019 pandemic. J Oral Sci 2021; 63: 107-110.
  26. N Hendrijantini, CK Hartono, RP Daniati, G Hong, RM Sitalaksmi, M Kuntjoro, MDA Aditya Ari: Human umbilical cord mesenchymal stem cell-induced osterix, bon morophogenetic protein-2, and tartrate-resistant acid phosphatase expression in osteoporotic mandibular bone. Eur J Dent 2021; 15: 84-89.
  27. TY Chang, G Hong, C Paganelli, P Phantumvanit, WJ Chang, YS Shieh, ML Hsu*: Innovation of dental education during COVID-19 pandemic. J Dent Sci 2021; 16: 15-20.
  28. G Hong*, Z Chen, JM Han, WQ Wang, P Gao, K Sasaki: Effect of amylase activity on mechanical properties of dental composite resin. Dent Mater J 2021; 40: 348-355.
  29. H Yang, DW Hong, G Hong, H Yu*: Effects of low-temperature degradation on the surface roughness of Y-TZP ceramics: A systematic review and meta-analysis. J Prosthet Dent 2021; 25: 222-230.
  30. G Hong*, WQ Wang, L Sun, JM Han, K Sasaki: The dynamic viscoelasticity of dental soft polymer material containing citrate eater-based plasticizers. Materials 2020; 13: 5078.
  31. T Kudo*, K Tominami, S Izumi, Y Hayashi, T Noguchi, A Matsuzawa, G Hong, J Nakai: Characterization of PC12 cell subclones with different sensitivities to programmed thermal stimulation. Int J Mol Sci 2020; 21: 8356.
  32. Georgios P*, Annesha A, Nemoto E, Hong G, Leung WK, McGrath C: Effects of adjunctive probiotic L.reuteri lozenges on NSPT outcomes at molar sites with deep pockets. J Clin Periodontol 2020; 47: 1098-1107.
  33. YD Zhang, G Hong, YF Zhang, K Sasaki, HK Wu*: Minimally invasive procedures for deficient interdental papillae: A review. J Esthet Restor Dent 2020; 32: 463-471.
  34. L Sun, G Hong*, H Matsui, YJ Song, K Sasaki: The effect of syndecan on osteoblastic cell adhesion onto nano-zirconia surface. Int J Nanomed 2020; 15: 5061-5072,.
  35. JJ Huang, H Yu, G Hong, H Cheng, M Zheng*: Influence of the tea extracts on the antifungal effect on Candida albicans. Dent Mater J 2020; 39: 664-669.
  36. W Zou, G Hong*, Y Yamazaki, T Ogawa, J Washio, N Takahashi, K Sasaki: Use of cellulose nanofibers as a denture immersing solution. Dent Mater J 2020; 39: 80-88.
  37. K Watanabe, G Hong, K Tominami, S Izumi, Y Hayashi, T-A Kudo: Association between beta3-adrenergic receptor Trp64Arg polymorphism and fat preference in healthy young Japanese women. Tohoku J Exp Med 2019; 248: 181-192.
  38. YY Qu, G Hong*, L Liu, K Sasaki, XD Chen: Evaluation of silk fibroin electrogel coating for zirconia material surface. Dent Mater J 2019; 38: 813-820.
  39. F Luo, G Hong*, H Matsui, K Endo, QB Wan, K Sasaki: Initial osteoblast adhesion and subsequent differentiation on zirconia surface are regulated by integrins and heparin-sensitive molecule. Int J Nanomed 2018; 13: 7657-7667.
  40. YJ Song, AB Ma, J Ning, X Zhong, Q Zhang, X Zhang, G Hong, Y Li*, K Sasaki, CY Li: Loading icariin on titanium surfaces by phase-transited lysozyme priming and layer-by-layer self-assembly of hyaluronic acid/chitosan to improve surface osteogenesis ability. Int J Nanomed 2018; 13: 6751-6767.
  41. H Oka, Y Ishida, G Hong: Study of factors related to the attitudes toward studying abroad among preclinical/clinical undergraduate dental students at three dental schools in Japan. Clin Exp Dent Res 2018; 4: 119-124.
  42. F Luo, G Hong, T Wang, LL Jia, JY Chen, L Suo, XB Pei, QB Wan*: Static and dynamic evaluations of the wettability of commercial vinyl polysiloxane impression materials for artificial saliva. Dent Mater J 2018; 37: 818-824.
  43. T Tanaka, G Hong, K Tominami, T Kudo: Oral Fat Sensitivity Is Associated with Social Support for Stress Coping in Young Adult Men. Tohoku J Exp Med 2018; 244: 249-261.
  44. H Oka, Y Ishida, G Hong, PTT Nguyen. Perceptions of dental students in Japanese national universities about studying abroad. Eur J Dent Educ 2018; 22: e1-e6.
  45. WQ Wang, G Hong*, JM Han, H Murata, K Sasaki: The effect of crude drugs on the angiogenic property and dynamic viscoelasticity of PEMA-based soft polymer materials. Dent Mater J 2017; 36: 770-777.
  46. F Luo, L Pan, G Hong, T Wang, X Pei, J Wang, Q Wan: In vitro and in vivo characterization of multi-walled carbon nanotubes/polycaprolactone composite scaffolds for bone tissue engineering applications. J Biomater Tiss Eng 2017; 7: 787-797.
  47. K Harada, S Miura, G Hong, T Hashida, H Abekura, H Murata, M Nishimura, H Nikawa.: Accelerating effects of cellulose in the removal of denture adhesives from acrylic denture base. J Prosthodont Res 2017; 61: 185-192.
  48. J Liu, G Hong*, YH Wu, K Endo, JM Han, H Kumamoto, T Wada, H Kato, K Sasaki: A novel method of surface modification by electrochemical deoxidation: effect on surface characteristics and initial bioactivity of zirconia. J Biomed Mater Res Part B 2017; 105B, 2641-2652.
  49. JM Han, G Hong*, H Lin, Y Shimizu, G Zheng, HY Zhang, K Sasaki: Biomechanical and histological evaluation of the osseointegration capacity of two types of zirconia implant. Int J Naomed 2016; 11: 6507-6516.
  50. S Izumi, G Hong, K Iwasaki, M Izumi, Y Matsuyama, M Chiba, T Toda, T Kudo*: Gustatory Salivation Is Associated with Body Mass Index, Daytime Sleepiness, and Snoring in Healthy Young Adults. Tohoku J Exp Med 2016; 240: 153-165.
  51. J Sun, E Nemoto, G Hong, K Sasaki. Modulation of stromal cell-derived factor 1 alpha (SDF-1α) and its receptor CXCR4 in Porphyromonas gingivalis-induced periodontal inflammation. BMC Oral Health 2016; 17: 26.
  52. K Harada-Hada*, G Hong, H Abekura, H Murata.: Evaluation of the efficiency of denture cleaner for removing denture adhesives. Gerodontology 2016; 33: 453-460.
  53. M Asano, G Hong, Y Matsuyama, WQ Wang, S Izumi, M Izumi, T Toda, T Kudo*: Association of Oral Fat Sensitivity with Body Mass Index, Taste Preference, and Eating Habits in Healthy Japanese Young Adults. Tohoku J Exp Med 2016; 238: 93-103.
  54. JM Han, G Hong*, MS Dilinuer, H Lin, G Zheng, XZ Wang, K Sasaki.: The adhesive strength and initial viscosity of denture adhesives. Acta Odontol Scand 2014; 72: 839-845.
  55. JM Han, G Hong*, H Matsui, Y Shimizu, G Zheng, H Lin, K Sasaki. The surface characterization and bioactivity of NANOZR in vitro. Dent Mater J 2014; 33: 210-219.
  56. JM Han, G Hong*, K Hayashida, T Maeda, H Murata, K Sasaki.: Influence of composition on the adhesive strength and initial viscosity of denture adhesives. Dent Mater J 2014; 33: 98-103.
  57. G. Hong*, T. Maeda, H. Murata, K. Sasaki.: The dynamic viscoelasticity and plasticizer leachability of tissue conditioners. Gerodontology 2012; 29: 284-291.
  58. G. Hong*, H. Tsuka, T. Maeda, Y. Akagawa, K. Sasaki.: The dynamic viscoelasticity and water absorption characteristics of soft acrylic resin materials containing adipates and maleate plasticizer. Dent Mater J 2012; 31: 139-149.
  59. T. Maeda, G. Hong*, S. Sadamori, T. Hamada, Y. Akagawa.: Durability of peel bond of resilient denture liners to acrylic denture base resin. J Prosthodont Res 2012; 56: 136-141.
  60. Hong G: Denture Care. Dental Diamond, Tokyo, 1st edition, P43, 2011.

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