Rehabilitation DentistryAdvanced Prosthetic Dentistry

The research and education of this division cover wide range of prosthodontic fields involving biomechanics, mechanobiology, stomatognathic function, and biomaterials. Our purpose is to restore, reconstruct and maintain the form and function of stomatognathic system. We are developing new treatment technology involving the use of implants, transplants, regenerative techniques and reconstructive techniques in addition to conventional dental prosthetic techniques. We also conduct various activities for biological, epidemiological and biomaterial researches based on biomechanics and mechanobiology at the interfaces between prostheses, biomaterials and the living body. We are developing various novel biomaterials, technologies and equipment collaborated with other disciplines in Tohoku University and other organizations. We hope to contribute the good quality of life (QOL) for people.


Topics of Research

  • Biomechanics and mechanobiology for stomatognathic morphology and function based on in vivo measurements and evaluation
  • Studies on transplantation, regeneration and construction for prosthodontics, implantology and maxillofacial rehabilitation
  • Studies on development and clinical application of novel biomaterials and creation of novel interfaces for prosthodontics, implantology and maxillofacial rehabilitation
  • Developmental and translational research for novel dental treatment technology and dental equipment based upon multi-disciplinary research and academia-industrial collaboration
  • Studies on clinical outcome of prosthodontics, implantology and maxillofacial rehabilitation

Recent Publications

  1. Assoratgoon I, Shiraishi N, Tagaino R, Ogawa T, Sasaki K. Sensory neuromuscular electrical stimulation for dysphagia rehabilitation: A literature review. J Oral Rehabil. 2023 Feb;50(2):157-164.
  2. Wang H, Tenkumo T, Nemoto E, Kanda Y, Ogawa T, Sasaki K. Introduction of tenomodulin by gene transfection vectors for rat bone tissue regeneration. Regen Ther. 2023 Jan 12;22:99-108.
  3. Ogawa T. Prediction of mandibular advancement splint treatment response: moving toward individualized therapy for obstructive sleep apnea. Sleep. 2022 Jun 13;45(6):zsac072.
  4. Hihara H, Izumita K, Iwatsu M, Sato T, Tagaino R, Shobara K, Shinohara Y, Hatakeyama T, Kayaba C, Sato M, Tokue A, Sugawara T, Ashino K, Ikeda K, Aida J, Sasaki K. Clinical Trial for Evaluating the Effectiveness and Safety of a New Dental Plaque Removal Device: Microscale Mist Unit. Antibiotics (Basel). 2022 Jun 19;11(6):825.
  5. Ogawa T, Sitalaksmi RM, Miyashita M, Maekawa K, Ryu M, Kimura-Ono A, Suganuma T, Kikutani T, Fujisawa M, Tamaki K, Kuboki T. Effectiveness of the socket shield technique in dental implant: A systematic review. J Prosthodont Res. 2022 Jan 11;66(1):12-18.
  6. Putra RH, Yoda N, Astuti ER, Sasaki K. The accuracy of implant placement with computer-guided surgery in partially edentulous patients and possible influencing factors: A systematic review and meta-analysis. J Prosthodont Res. 2022 Jan 11;66(1):29-39.
  7. Shimada E, Hihara H, Kitayama C, Kanno A, Kawashima R, Sato A, Imai Y, Nakasato N, Igarashi K, Kanetaka H. Somatosensory evoked magnetic fields induced by electrical palate stimulation in patients with unilateral cleft lip and palate after palatoplasty. Neurosci Res. 2022 Nov;184:30-37.
  8. Wan B, Yoda N, Zheng K, Zhang Z, Wu C, Clark J, Sasaki K, Swain M, Li Q. On interaction between fatigue of reconstruction plate and time-dependent bone remodeling. J Mech Behav Biomed Mater. 2022 Oct 4;136:105483.
  9. Takahashi M, Yamaguchi H, Takada Y. Ideal set-up angle between a pair of oval dental magnetic attachments for suppression of the loss in retentive force associated with horizontal displacement. Heliyon. 2022 Aug 22;8(8):e10361.
  10. Yoda N, Abe Y, Suenaga Y, Matsudate Y, Hoshino T, Sugano T, Nakamura K, Okino A, Sasaki K. Resin Cement-Zirconia Bond Strengthening by Exposure to Low-Temperature Atmospheric Pressure Multi-Gas Plasma. Materials (Basel). 2022 Jan 14;15(2):631.
  11. Sugano T, Ogawa T, Yoda N, Hashimoto T, Shobara K, Niizuma K, Kawashima R, Sasaki K. Morphological comparison of masseter muscle fibres in the mandibular rest and open positions using diffusion tensor imaging. J Oral Rehabil. 2022 Jun;49(6):608-615.
  12. Zheng K, Yoda N, Chen J, Liao Z, Zhong J, Wu C, Wan B, Koyama S, Sasaki K, Peck C, Swain M, Li Q. Bone remodeling following mandibular reconstruction using fibula free flap. J Biomech. 2022 Mar;133:110968.
  13. Koyama S, Izumita K, Sato N, Tagaino R, Hatakeyama T, Shiraishi N, Yoda N, Igarashi K, Takahashi T, Sasaki K. Medical-Dental Collaboration and Interprofessional Training for Maxillofacial Diseases at Tohoku University Hospital. Tohoku J Exp Med. 2022 Mar;256(3):225-234.
  14. Sugano T, Yoda N, Ogawa T, Hashimoto T, Shobara K, Niizuma K, Kawashima R, Sasaki K. Application of Diffusion Tensor Imaging Fiber Tractography for Human Masseter Muscle. Tohoku J Exp Med. 2022 Feb;256(2):151-160.
  15. Kakinuma H, Izumita K, Yoda N, Egusa H, Sasaki K. Comparison of the accuracy of resin-composite crowns fabricated by three-dimensional printing and milling methods. Dent Mater J. 2022 Nov 30;41(6):808-815.
  16. Xiang C, Tenkumo T, Ogawa T, Kanda Y, Nakamura K, Shirato M, Sokolova V, Epple M, Kamano Y, Egusa H, Sasaki K. Gene transfection achieved by utilizing antibacterial calcium phosphate nanoparticles for enhanced regenerative therapy. Acta Biomater. 2021 Jan 1;119:375-389.
  17. Tagaino R, Washio J, Otani H, Sasaki K, Takahashi N. Bifacial biological effects of ethanol: acetaldehyde production by oral Streptococcus species and the antibacterial effects of ethanol against these bacteria. J Oral Microbiol. 2021 Jun 9;13(1):1937884.
  18. Shobara K, Ogawa T, Shibamoto A, Miyashita M, Ito A, Sitalaksmi RM. Osteogenic effect of low-intensity pulsed ultrasound and whole-body vibration on peri-implant bone. An experimental in vivo study. Clin Oral Implants Res. 2021 May;32(5):641-650.
  19. Shinohara Y, Washio J, Kobayashi Y, Abiko Y, Sasaki K, Takahashi N. Hypoxically cultured cells of oral squamous cell carcinoma increased their glucose metabolic activity under normoxic conditions. PLoS One. 2021 Oct 22;16(10):e0254966.
  20. Hihara H, Tagaino R, Washio J, Laosuwan K, Wicaksono DP, Izumita K, Koide R, Takahashi N, Sasaki K. Effectiveness and safety of a new dental plaque removal device utilizing micro mist spray for removing oral biofilm in vitro. BMC Oral Health. 2021 Jun 4;21(1):286.
  21. Putra RH, Doi C, Yoda N, Astuti ER, Sasaki K. Current applications and development of artificial intelligence for digital dental radiography. Dentomaxillofac Radiol. 2022 Jan 1;51(1):20210197.
  22. Nii M, Yoda N, Putra RH, Aida J, Sasaki K. Evaluation of the optimal hardness and thickness of music splints for wind instrument players. J Prosthet Dent. 2021 Aug 4:S0022-3913(21)00362-0.
  23. Assoratgoon I, Yoda N, Iwamoto M, Sato T, Kawata T, Egusa H, Sasaki K. In vivo measurement of three-dimensional load exerted on dental implants: a literature review. Int J Implant Dent. 2022 Nov 14;8(1):52.
  24. Putra RH, Yoda N, Astuti ER, Sasaki K. Potential Imaging Capability of Optical Coherence Tomography as Dental Optical Probe: A Mini-Review. Applied Sciences. 2021; 11(22):11025.
  25. Ohkoshi A, Sato N, Kurosawa K, Miyashita H, Ishii R, Nakanome A, Ogawa T, Tachi M, Takahashi T, Katori Y. Impact of CAD/CAM mandibular reconstruction on chewing and swallowing function after surgery for locally advanced oral cancer: A retrospective study of 50 cases. Auris Nasus Larynx. 2021 Oct;48(5):1007-1012.
  26. Shobara K, Ogawa T, Sitalaksmi RM, Ito A, Miyashita M, Shibamoto A, Sasaki K. Tightening and Loosening of the Abutment Screw Negatively Affects Implant Osseointegration in the Early Healing Stage in Rat Tibiae. Int J Prosthodont. 2021 March/April;34(2):199–203.
  27. Tenkumo T, Rojas-Sánchez L, Vanegas Sáenz JR, Ogawa T, Miyashita M, Yoda N, Prymak O, Sokolova V, Sasaki K, Epple M. Reduction of inflammation in a chronic periodontitis model in rats by TNF-α gene silencing with a topically applied siRNA-loaded calcium phosphate paste. Acta Biomater. 2020 Mar 15;105:263-279.
  28. Tenkumo T, Ishiyama K, Prymak O, Nakamura K, Shirato M, Ogawa T, Miyashita M, Takahashi M, Epple M, Kanno T, Sasaki K. Bactericidal activity and recovery effect of hydroxyl radicals generated by ultraviolet irradiation and silver ion application on an infected titanium surface. Sci Rep. 2020 May 22;10(1):8553.

Laboratory Contacts