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口腔システム補綴学分野

分野の紹介

歯、顎骨等、顎口腔組織の欠損を回復するにあたっては、形態のみならず、その機能、生体力学的要件、力に対する生体反応、さらに治療に用いるバイオマテリアルと生体との生物学的、生体力学的なインターフェイスを考慮する必要があります。当分野では、これらをターゲットとして、異分野融合、産学連携のもと、補綴歯科治療の進展に寄与するバックグラウンドの解明、ならびに新たな治療技術、バイオマテリアル、医療機器の開発研究に取り組んでいます。

教員構成

  • 佐々木 啓一教授:佐々木 啓一

主な研究テーマ

  • 生体情報の実測に基づく顎口腔系のバイオメカニクス、メカノバイオロジー
  • 欠損補綴・インプラント補綴・顎顔面再建における移植・再生・創建に関する研究
  • 欠損補綴・インプラント補綴・顎顔面再建における新規バイオマテリアルの開発と応用、機能性インターフェイスの創生に関する研究
  • 異分野融合・産学連携による新規歯科医療技術・歯科医療機器の開発とトランスレーショナルリサーチ
  • 欠損補綴・インプラント補綴・顎顔面再建の臨床アウトカムに関する研究

最近の業績

  1. Sato T, Anada T, Hamai R, Shiwaku Y, Tsuchiya K, Sakai S, Baba K, Sasaki K, Suzuki O. Culture of hybrid spheroids composed of calcium phosphate materials and mesenchymal stem cells on an oxygen-permeable culture device to predict in vivo bone forming capability. Acta Biomater. 2019 Mar 4. pii: S1742-7061(19)30167-9.
  2. Luo F, Hong G, Matsui H, Endo K, Wan Q, Sasaki K. Initial osteoblast adhesion and subsequent differentiation on zirconia surfaces are regulated by integrins and heparin-sensitive molecule. Int J Nanomedicine. 2018 Nov 19;13:7657-7667.
  3. Tenkumo T, Vanegas Sáenz JR, Nakamura K, Shimizu Y, Sokolova V, Epple M, Kamano Y, Egusa H, Sugaya T, Sasaki K. Prolonged release of bone morphogenetic protein-2 in vivo by gene transfection with DNA-functionalized calcium phosphate nanoparticle-loaded collagen scaffolds. Mater Sci Eng C Mater Biol Appl. 2018 Nov 1;92:172-183.
  4. Wang S, Ogawa T, Zheng S, Miyashita M, Tenkumo T, Gu Z, Lian W, Sasaki K. The effect of low-magnitude high-frequency loading on peri-implant bone healing and implant osseointegration in Beagle dogs. J Prosthodont Res. 2018 Oct;62(4):497-502.
  5. Suenaga H, Tamahara T, Dodo M, Murakami T, Sasaki S, Ito K, Jingu K, Koseki T, Sasaki K. Design of the spacer for brachytherapy using (198)Au grain for carcinoma of the tongue as a tool of perioperative oral management. J Prosthodont Res. 2018 Oct;62(4):518-521.
  6. Miyashita M, Ogawa T, Naito H, Shibamoto A, Wang AS, Shobara K, Sasaki K. Evaluation of implant screw loosening by resonance frequency analysis with triaxial piezoelectric pick-up: in vitro model and in vivo animal study. Clin Oral Investig. 2018 Jun;22(5):2129-2134.
  7. Yoda N, Zheng K, Chen J, Liao Z, Koyama S, Peck C, Swain M, Sasaki K, Li Q. Biomechanical analysis of bone remodeling following mandibular reconstruction using fibula free flap. Med Eng Phys. 2018 Jun;56:1-8.
  8. Shibamoto A, Ogawa T, Duyck J, Vandamme K, Naert I, Sasaki K. Effect of high-frequency loading and parathyroid hormone administration on peri-implant bone healing and osseointegration. Int J Oral Sci. 2018 Mar 13;10(1):6.
  9. Koyama S, Kato H, Harata T, Sato N, Hanawa S, Sasaki K. Evaluation of water absorption properties and fabrication of hollow obturator model using 3D digital dentistry. Dent Mater J. 2018 Jul 29;37(4):521-525.
  10. Chaweewannakorn C, Tsuchiya M, Koide M, Hatakeyama H, Tanaka Y, Yoshida S, Sugawara S, Hagiwara Y, Sasaki K, Kanzaki M. Roles of IL-1α/β in regeneration of cardiotoxin-injured muscle and satellite cell function. Am J Physiol Regul Integr Comp Physiol. 2018 Jul 1;315(1):R90-R103.
  11. Yamamoto M, Ogawa T, Yokoyama M, Funaki Y, Shobara K, Shibamoto A, Vanegas Sáenz JR, Sasaki K. Na(18)F accumulates on the compressive side of peri-implant bone under immediate loading. Odontology. 2018 Jul;106(3):232-237.
  12. Vanegas Sáenz JR, Tenkumo T, Kamano Y, Egusa H, Sasaki K. Amiloride-enhanced gene transfection of octa-arginine functionalized calcium phosphate nanoparticles. PLoS One. 2017 Nov 16;12(11):e0188347. doi:10.1371/journal.pone.0188347. eCollection 2017. PubMed PMID: 29145481; PubMed Central PMCID: PMC5690608.
  13. Fukushima A, Mayanagi G, Sasaki K, Takahashi N. Corrosive effects of fluoride on titanium under artificial biofilm. J Prosthodont Res. 2018 Jan;62(1):104-109.
  14. Suzuki T, Ogawa T, Long J, Vanegas Sáenz JR, Miyashita M, Matsuda M, Sasaki K. Periodontal tactile sensation and occlusal loading condition of autotransplanted teeth: A retrospective pilot study. J Prosthodont Res. 2018 Jan;62(1):84-88.
  15. Long J, Ogawa T, Ito T, Matsuda M, Li W, Yu H, Sasaki K. Effect of bite openings and mandibular protrusion on genioglossus muscle activity in healthy adults with oral appliance. Odontology. 2018 Jan;106(1):90-95.
  16. Yoda N, Zheng K, Chen J, Li W, Swain M, Sasaki K, Li Q. Bone morphological effects on post-implantation remodeling of maxillary anterior buccal bone: A clinical and biomechanical study. J Prosthodont Res. 2017 Oct;61(4):393-402.
  17. Han JM, Hong G, Lin H, Shimizu Y, Wu Y, Zheng G, Zhang H, Sasaki K. Biomechanical and histological evaluation of the osseointegration capacity of two types of zirconia implant. Int J Nanomedicine. 2016 Dec 7;11:6507-6516.
  18. Matsuo Y, Ogawa T, Yamamoto M, Shibamoto A, Sáenz JRV, Yokoyama M, Kanda Y, Toyohara J, Sasaki K. Evaluation of peri-implant bone metabolism under immediate loading using high-resolution Na(18)F-PET. Clin Oral Investig. 2017 Jul;21(6):2029-2037.
  19. Liu J, Hong G, Wu YH, Endo K, Han JM, Kumamoto H, Wada T, Kato H, Gao P, Sasaki K. A novel method of surface modification by electrochemical deoxidation: Effect on surface characteristics and initial bioactivity of zirconia. J Biomed Mater Res B Appl Biomater. 2017 Nov;105(8):2641-2652.

分野問い合わせ

E-mail:junko.hagawa.a3*tohoku.ac.jp(*を@に変えてください。)
TEL:81-22-717-8369
FAX:81-22-717-8371

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