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口腔システム補綴学分野

分野の紹介

歯、顎骨等、顎口腔組織の欠損を回復するにあたっては、形態のみならず、その機能、生体力学的要件、力に対する生体反応、さらに治療に用いるバイオマテリアルと生体との生物学的、生体力学的なインターフェイスを考慮する必要があります。当分野では、これらをターゲットとして、異分野融合、産学連携のもと、補綴歯科治療の進展に寄与するバックグラウンドの解明、ならびに新たな治療技術、バイオマテリアル、医療機器の開発研究に取り組んでいます。

教員構成

主な研究テーマ

  • 生体情報の実測に基づく顎口腔系のバイオメカニクス、メカノバイオロジー
  • 欠損補綴・インプラント補綴・顎顔面再建における移植・再生・創建に関する研究
  • 欠損補綴・インプラント補綴・顎顔面再建における新規バイオマテリアルの開発と応用、機能性インターフェイスの創生に関する研究
  • 異分野融合・産学連携による新規歯科医療技術・歯科医療機器の開発とトランスレーショナルリサーチ
  • 欠損補綴・インプラント補綴・顎顔面再建の臨床アウトカムに関する研究

最近の業績

  1. Putra RH, Cooray U, Nurrachman AS, Yoda N, Judge R, Putri DK, Astuti ER. Radiographic alveolar bone assessment in correlation with primary implant stability: A systematic review and meta-analysis. Clin Oral Implants Res. 2024 Jan;35(1):1-20.
  2. Poovarodom P, Rungsiyakull C, Suriyawanakul J, Li Q, Sasaki K, Yoda N, Rungsiyakull P. Effect of customized abutment taper configuration on bone remodeling and peri-implant tissue around implant-supported single crown: A 3D nonlinear finite element study. J Prosthodont. 2023 Sep 28. doi: 10.1111/jopr.13776.
  3. Poovarodom P, Rungsiyakull C, Suriyawanakul J, Li Q, Sasaki K, Yoda N, Rungsiyakull P. Effect of gingival height of a titanium base on the biomechanical behavior of 2-piece custom implant abutments: A 3-dimensional nonlinear finite element study. J Prosthet Dent. 2023 Sep;130(3):380.e1-380.e9.
  4. Putra RH, Astuti ER, Putri DK, Widiasri M, Laksanti PAM, Majidah H, Yoda N. Automated permanent tooth detection and numbering on panoramic radiograph using a deep learning approach. Oral Surg Oral Med Oral Pathol Oral Radiol. 2023 Jun 8:S2212-4403(23)00505-9.
  5. Ichikawa H, Yoda N, Ogawa T, Iwamoto M, Kawata T, Egusa H, Sasaki K. Impact of implant location on load distribution of implant-assisted removable partial dentures: a review of in vitro model and finite-element analysis studies. Int J Implant Dent. 2023 Sep 19;9(1):31.
  6. Numazaki K, Seiryu M, Yamauchi K, Yoda N, Ito A, Mizoguchi I. Combined surgical-orthodontic and prosthetic treatment of a partially edentulous patient with skeletal Class III malocclusion. Clinical and Investigative Orthodontics. 2023, 82(3), 165-174.
  7. Hihara H, Izumita K, Kawata T, Akatsuka R, Tagaino R, Kitaoka A, Kayaba C, Ikeda K, Sasaki K. A novel treatment based on powder jet deposition technique for dentin hypersensitivity: a randomized controlled trial. BMC Oral Health. 2023, 27;23(1):695.
  8. Assoratgoon I, Shiraishi N, Tagaino R, Ogawa T, Sasaki K. Sensory neuromuscular electrical stimulation for dysphagia rehabilitation: A literature review. J Oral Rehabil. 2023 Feb;50(2):157-164.
  9. Wang H, Tenkumo T, Nemoto E, Kanda Y, Ogawa T, Sasaki K. Introduction of tenomodulin by gene transfection vectors for rat bone tissue regeneration. Regen Ther. 2023 Jan 12;22:99-108.
  10. Ogawa T. Prediction of mandibular advancement splint treatment response: moving toward individualized therapy for obstructive sleep apnea. Sleep. 2022 Jun 13;45(6):zsac072.
  11. Hihara H, Izumita K, Iwatsu M, Sato T, Tagaino R, Shobara K, Shinohara Y, Hatakeyama T, Kayaba C, Sato M, Tokue A, Sugawara T, Ashino K, Ikeda K, Aida J, Sasaki K. Clinical Trial for Evaluating the Effectiveness and Safety of a New Dental Plaque Removal Device: Microscale Mist Unit. Antibiotics (Basel). 2022 Jun 19;11(6):825.
  12. Ogawa T, Sitalaksmi RM, Miyashita M, Maekawa K, Ryu M, Kimura-Ono A, Suganuma T, Kikutani T, Fujisawa M, Tamaki K, Kuboki T. Effectiveness of the socket shield technique in dental implant: A systematic review. J Prosthodont Res. 2022 Jan 11;66(1):12-18.
  13. Putra RH, Yoda N, Astuti ER, Sasaki K. The accuracy of implant placement with computer-guided surgery in partially edentulous patients and possible influencing factors: A systematic review and meta-analysis. J Prosthodont Res. 2022 Jan 11;66(1):29-39.
  14. Shimada E, Hihara H, Kitayama C, Kanno A, Kawashima R, Sato A, Imai Y, Nakasato N, Igarashi K, Kanetaka H. Somatosensory evoked magnetic fields induced by electrical palate stimulation in patients with unilateral cleft lip and palate after palatoplasty. Neurosci Res. 2022 Nov;184:30-37.
  15. Wan B, Yoda N, Zheng K, Zhang Z, Wu C, Clark J, Sasaki K, Swain M, Li Q. On interaction between fatigue of reconstruction plate and time-dependent bone remodeling. J Mech Behav Biomed Mater. 2022 Oct 4;136:105483.
  16. Takahashi M, Yamaguchi H, Takada Y. Ideal set-up angle between a pair of oval dental magnetic attachments for suppression of the loss in retentive force associated with horizontal displacement. Heliyon. 2022 Aug 22;8(8):e10361.
  17. Yoda N, Abe Y, Suenaga Y, Matsudate Y, Hoshino T, Sugano T, Nakamura K, Okino A, Sasaki K. Resin Cement-Zirconia Bond Strengthening by Exposure to Low-Temperature Atmospheric Pressure Multi-Gas Plasma. Materials (Basel). 2022 Jan 14;15(2):631.
  18. Sugano T, Ogawa T, Yoda N, Hashimoto T, Shobara K, Niizuma K, Kawashima R, Sasaki K. Morphological comparison of masseter muscle fibres in the mandibular rest and open positions using diffusion tensor imaging. J Oral Rehabil. 2022 Jun;49(6):608-615.
  19. Zheng K, Yoda N, Chen J, Liao Z, Zhong J, Wu C, Wan B, Koyama S, Sasaki K, Peck C, Swain M, Li Q. Bone remodeling following mandibular reconstruction using fibula free flap. J Biomech. 2022 Mar;133:110968.
  20. Koyama S, Izumita K, Sato N, Tagaino R, Hatakeyama T, Shiraishi N, Yoda N, Igarashi K, Takahashi T, Sasaki K. Medical-Dental Collaboration and Interprofessional Training for Maxillofacial Diseases at Tohoku University Hospital. Tohoku J Exp Med. 2022 Mar;256(3):225-234.
  21. Sugano T, Yoda N, Ogawa T, Hashimoto T, Shobara K, Niizuma K, Kawashima R, Sasaki K. Application of Diffusion Tensor Imaging Fiber Tractography for Human Masseter Muscle. Tohoku J Exp Med. 2022 Feb;256(2):151-160.
  22. Kakinuma H, Izumita K, Yoda N, Egusa H, Sasaki K. Comparison of the accuracy of resin-composite crowns fabricated by three-dimensional printing and milling methods. Dent Mater J. 2022 Nov 30;41(6):808-815.
  23. Xiang C, Tenkumo T, Ogawa T, Kanda Y, Nakamura K, Shirato M, Sokolova V, Epple M, Kamano Y, Egusa H, Sasaki K. Gene transfection achieved by utilizing antibacterial calcium phosphate nanoparticles for enhanced regenerative therapy. Acta Biomater. 2021 Jan 1;119:375-389.
  24. Tagaino R, Washio J, Otani H, Sasaki K, Takahashi N. Bifacial biological effects of ethanol: acetaldehyde production by oral Streptococcus species and the antibacterial effects of ethanol against these bacteria. J Oral Microbiol. 2021 Jun 9;13(1):1937884.
  25. Shobara K, Ogawa T, Shibamoto A, Miyashita M, Ito A, Sitalaksmi RM. Osteogenic effect of low-intensity pulsed ultrasound and whole-body vibration on peri-implant bone. An experimental in vivo study. Clin Oral Implants Res. 2021 May;32(5):641-650.
  26. Shinohara Y, Washio J, Kobayashi Y, Abiko Y, Sasaki K, Takahashi N. Hypoxically cultured cells of oral squamous cell carcinoma increased their glucose metabolic activity under normoxic conditions. PLoS One. 2021 Oct 22;16(10):e0254966.
  27. Hihara H, Tagaino R, Washio J, Laosuwan K, Wicaksono DP, Izumita K, Koide R, Takahashi N, Sasaki K. Effectiveness and safety of a new dental plaque removal device utilizing micro mist spray for removing oral biofilm in vitro. BMC Oral Health. 2021 Jun 4;21(1):286.
  28. Putra RH, Doi C, Yoda N, Astuti ER, Sasaki K. Current applications and development of artificial intelligence for digital dental radiography. Dentomaxillofac Radiol. 2022 Jan 1;51(1):20210197.
  29. Nii M, Yoda N, Putra RH, Aida J, Sasaki K. Evaluation of the optimal hardness and thickness of music splints for wind instrument players. J Prosthet Dent. 2021 Aug 4:S0022-3913(21)00362-0.
  30. Assoratgoon I, Yoda N, Iwamoto M, Sato T, Kawata T, Egusa H, Sasaki K. In vivo measurement of three-dimensional load exerted on dental implants: a literature review. Int J Implant Dent. 2022 Nov 14;8(1):52.
  31. Putra RH, Yoda N, Astuti ER, Sasaki K. Potential Imaging Capability of Optical Coherence Tomography as Dental Optical Probe: A Mini-Review. Applied Sciences. 2021; 11(22):11025.
  32. Ohkoshi A, Sato N, Kurosawa K, Miyashita H, Ishii R, Nakanome A, Ogawa T, Tachi M, Takahashi T, Katori Y. Impact of CAD/CAM mandibular reconstruction on chewing and swallowing function after surgery for locally advanced oral cancer: A retrospective study of 50 cases. Auris Nasus Larynx. 2021 Oct;48(5):1007-1012.
  33. Shobara K, Ogawa T, Sitalaksmi RM, Ito A, Miyashita M, Shibamoto A, Sasaki K. Tightening and Loosening of the Abutment Screw Negatively Affects Implant Osseointegration in the Early Healing Stage in Rat Tibiae. Int J Prosthodont. 2021 March/April;34(2):199–203.
  34. Tenkumo T, Rojas-Sánchez L, Vanegas Sáenz JR, Ogawa T, Miyashita M, Yoda N, Prymak O, Sokolova V, Sasaki K, Epple M. Reduction of inflammation in a chronic periodontitis model in rats by TNF-α gene silencing with a topically applied siRNA-loaded calcium phosphate paste. Acta Biomater. 2020 Mar 15;105:263-279.
  35. Tenkumo T, Ishiyama K, Prymak O, Nakamura K, Shirato M, Ogawa T, Miyashita M, Takahashi M, Epple M, Kanno T, Sasaki K. Bactericidal activity and recovery effect of hydroxyl radicals generated by ultraviolet irradiation and silver ion application on an infected titanium surface. Sci Rep. 2020 May 22;10(1):8553.

分野問い合わせ

E-mail:junko.hagawa.a3*tohoku.ac.jp(*を@に変えてください。)
TEL:81-22-717-8369
FAX:81-22-717-8371

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