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Molecular Oral Oncology


Squamous cell carcinoma (SCC) is the most common type of oral carcinoma. In many human cancers including SCC, aberrant activation of a transcription factor Nrf2 has been detected, which strongly correlates with the poor clinical outcome. We are working on the role Nrf2 plays in cancer cells. Our goal is to clarify the molecular mechanisms underlying the malignant evolution of cancers.

Faculty configuration

  • Prof.Hozumi Motohashi

Topics of Research

  • Roles of Nrf2 in Cancer Initiation and Promotion
  • Stress Response Mechanism and Metabolic Reprogramming in Cancer Cells
  • Intranuclear Redox Homeostasis and Genome Protection in Carcinogenesis
  • Stress Response Mechanism in Cell Senescence

Laboratory Contacts

E-mail:hozumim*idac.tohoku.ac.jp (Please change * to @.)