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Oral Cancer Therapeutics


Small GTPases function as molecular switches in cell proliferation, cell movement and intracellular traffic. We are investigating roles of small GTPases in oral cancer proliferation, invasion and metastasis. Bisphosphonates are used for the therapy of osteoporosis by inhibiting lipid modification of small GTPases in osteoclasts. We are also investigating about the posttranslational lipid modification.

Faculty configuration

    Prof.Hisanori Horiuchi

Topics of Research

  • Regulatory Mechanism of Oral Tumor Proliferation, Invasion and Metastasis by Small GTPases
  • Research on Lipid Modification of small GTPases
  • Sensing Mechanism of Intracellular Nutrients
  • Basic and Clinical Research on Thrombus Formation

Laboratory Contacts

E-mail:horiuchi*idac.tohoku.ac.jp (Please change * to @.)