HOME > Guide of course > Dental and Oral Anesthesiology

Dental and Oral Anesthesiology


Research is essential for improving patients’ care. The mission of the Department of Dento-oral Anesthesiology is to become a premier center of clinical and translational research for dental anesthesiology.

Exploring Novel Therapeutic Targets for Bronchospasm and Asthma:
Peri-operative bronchospasm remains a clinical problem for the anesthesiologist due in part to inadequate therapies for controlling airway smooth muscle tone. Our main area of research interests is in the identification of novel therapeutic targets (GPCRs) of bronchospasm and asthma, and understanding of their signal transduction pathways. Our department has collaborated with Department of Anesthesiology at Columbia University College of Physicians and Surgeons over 10 years.

Exploring Novel Therapeutic Strategies for Orofacial Pain:
Trigeminal neuralgia is one of the most common types of orofacial pain. Our department investigates the role of channels and GPCRs that contributes pathogenesis of orofacial pain.

Parasympathetic reflex vasodilatation in orofacial area:
Blood flow in orofacial area is regulated by the parasympathetic nervous system. We have focused on the effect of anesthetics on parasympathetic reflex vasodilatation in orofacial area.

Faculty configuration

  • Kentaro Mizuta
    Prof. Kentaro Mizuta

Topics of Research

  • Obesity-induced asthma
  • GPCRs-mediated bronchospasm and asthma
  • Contribution of oral and gut microbiota on pathogenesis of asthma
  • Research on parasympathetic reflex vasodilatation in orofacial area

Recent Publications

  1. Matoba A, Matsuyama N, Shibata S, Masaki E, Emala CW, and Mizuta K. The free fatty acid receptor 1 promotes airway smooth muscle cell proliferation through MEK/ERK and PI3K/Akt signaling pathways. Am. J. Physiol. Lung Cell. Mol. Physiol., 314(3): L333-L348, 2018.
  2. Matsuyama N, Shibata S, Matoba A, Kudo T, Danielsson J, Kohjitani A, Masaki E, Emala CW, and Mizuta K: The dopamine D1 receptor is expressed and induces CREB phosphorylation and MUC5AC expression in human airway epithelium. Respir. Res., 19(1): 53, 2018.
  3. Hoshijima H, Mihara T, Maruyama K, Denawa Y, Mizuta K, Shiga T, and Nagasaka H. C-MAC videolaryngoscope versus Macintosh laryngoscope for tracheal intubation: a systematic review and meta-analysis with trial sequential analysis. J. Clin. Anesth., 49: 53-62, 2018.
  4. Hoshijima H, Takeuchi R, Mihara T, Kuratani N, Mizuta K, Wajima Z, Masaki E, and Shiga T. Weekend versus weekday admission and short-term mortality: A meta-analysis of 88 cohort studies including 56,934,649 participants. Medicine (Baltimore), 96: e6685, 2017.
  5. Masaki E, Mizuta K, Ohtani N, and Kido K.: Early postoperative nociceptive threshold and production of brain-derived neurotrophic factor induced by plantar incision are not influenced with minocycline in a rat: role of spinal microglia. Neurosignals., 24(1): 15-24, 2016.
  6. Mizuta K, Zhang Y, Mizuta F, Hoshijima H, Shiga T, Masaki E, and Emala CW. Novel identification of the free fatty acid receptor FFAR1 that promotes contraction in airway smooth muscle. Am J Physiol Lung Cell Mol Physiol, 309(9): L970-L982, 2015.
  7. Mizuta K, Zhang Y, Xu D, Mizuta F, D’Ovidio F, Masaki E, and Emala CW. The dopamine D1 receptor is expressed and facilitates relaxation in airway smooth muscle. Respir. Res. 14:89, 2013.
  8. Mizuta K, Zhang Y, Xu D, Masaki E, Panettieri RA Jr., and Emala CW. The dopamine D2 receptor is expressed and sensitizes adenylyl cyclase activity in airway smooth muscle. Am. J. Physiol. Lung Cell. Mol. Physiol., 302(3):L316-324, 2012.
  9. Kawakami S, Izumi H, Masaki E, Kuchiiwa S, and Mizuta K. Role of medullary GABA signal transduction on parasympathetic reflex vasodilatation in the lower lip. Brain Res., 1437:26-37, 2012.
  10. Izumi H, Ishii H, and Mizuta K. Anterior hypothalamic inhibition of reflex parasympathetic vasodilatation in the lower lip and palate of anaesthetized cats. Dent. J. Health., 30(2): 43-52, 2011.
  11. Mizuta K, Mizuta F, Xu D, Masaki E, Panettieri RA Jr., and Emala CW. Gi-coupled γ-aminobutyric acid-B receptors cross-regulate phospholipase C and calcium in airway smooth muscle. Am. J. Respir. Cell Mol. Biol., 45(6):1232-1238, 2011.

Laboratory Contacts

E-mail: kentaro.mizuta.e6*tohoku.ac.jp (Please change * to @.)