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Oral Diagnosis


It is said that there are about 220 kinds of diseases originating in the oral cavity. Their causes vary, but sometimes their symptoms partly overlap with those of systemic illnesses or concomitant diseases. For example, there are cases when the cause of gingival bleeding is leukemia or the cause of toothache is a brain tumor. In the oral diagnosis department, we focus on the relationship between the body and oral health and conduct research on oral diseases from oral medicine, oral diagnosis and oral radiology viewpoints.

Clinically, we propel physiological and immunological research on taste disorders and xerostomia. Furthermore, to provide more comprehensive medical treatment, our oral medical therapy takes the whole body into consideration.

In regards to theoretical research, the functional correlation between pain and blood flow is our primary research interest. We have demonstrated proved that vasodilatation and plasma leakage are evoked in the innervated areas (e.g., dental pulp and oral mucosa) when sensory nerves are stimulated in a peripheral direction (antidromical stimulation) (Professor Takashi Sasano: J Dent Res, 1996). garnered attention as an example of neurogenic inflammatory response in the oral area. Please see below for information on our other research.

Faculty configuration

  • Prof. Tetsu Takahashi (collateral office)

Topics of Research

  • Research on systemic illnesses and oral symptoms
  • Research on diagnosis and treatment of taste disorder
  • Research on the diagnosis and medical therapy of oral mucosal disease
  • Research on the functional correlation between pain and blood flow
  • Research on diagnostic imaging of oral diseases

Recent Performance

  1. Diagnostic performance of MR imaging of three major salivary glands for Sjögren’s syndrome
    Kojima I, Sakamoto M, Iikubo M, Kumamoto H, Muroi A, Sugawara Y, Satoh-Kuriwada S, Sasano T
    Oral Diseases 23: 84-90, 2017. DOI:10.1111/odi.12577
  2. Umami: Why is the fifth taste so important?
    Takashi Sasano
    NATURE. 9 JUNE 2016. Vol 534. No. 7606.
  3. Editorial: Sensory Science of Oral Health for Creating New Preventive Medicines
    Sasano T, Uneyama H, Hummel T
    Curr Pharm Des. 2016; 22(15):2193-2194.
  4. Clinical Significance of Umami Taste and Umami-Related Gene Expression Analysis for the Objective Assessment of Umami Taste Loss.
    Shoji N, Satoh-Kuriwada S, Sasano T
    Curr Pharm Des. 2016; 22(15):2238-2244.
  5. Dentin hypersensitivity-like tooth pain seen in patients receiving steroid therapy: An exploratory study.
    Shoji N, Endo Y, Iikubo M, Ishii T, Harigae H, Aida J, Sakamoto M, Sasano T.
    J Pharmacol Sci. 2016 Nov;132(3):187-191. doi: 10.1016/j.jphs.2016.10.004.
  6. Influence of voxel size and scan field of view on fracture-like artifacts from gutta-percha obturated endodontically treated teeth on cone-beam computed tomography images.
    Iikubo M, Nishioka T, Okura S, Kobayashi K, Sano T, Katsumata A, Ariji E, Kojima I, Sakamoto M, Sasano T.
    Oral Surg Oral Med Oral Pathol Oral Radiol. 122、631-637、2016
  7. The important role of umami taste in oral and overall health
    Takashi Sasano, Shizuko Satoh-Kuriwada, Noriaki Shoji
    Flavour 2015, 4:10 doi: 10.1186/2044-7248-4-10
  8. Comparison of bisecting and paralleling intraoral radiography and cone beam computed tomography for detection of various horizontal angle root fractures.
    Iikubo M, Kamio T, Hashimoto N, Nishioka T, Wakoh M, Sano T, Igarashi C, Kobayashi K, Seki K, Katsumata A, Ariji E, Sasano T, Sakamoto M, Kojima I.
    Oral Radiol. 31, 173-180, 2015
  9. Root canal filling materials spread pattern mimicking root fractures in dental CBCT images.
    Iikubo M, Osano T, Sano T, Katsumata A, Ariji E, Kobayashi K, Sasano T, Wakoh M, Seki K, Kojima I, Sakamoto M.
    Oral Surg Oral Med Oral Pathol Oral Radiol. 120, 521-527, 2015.
  10. Insulin-like growth factor I inhibits alveolar bone loss following tooth extraction in rats.
    Akira Kumasaka, Masahiro Iikubo, Takashi Nishioka, Ikuho Kojima, Noriaki Shoji, Maya Sakamoto, Takashi Sasano.
    Clin Implant Dent Relat Res. 2015 December; 17(6): 1174-1179.

Laboratory Contacts

E-mail:tsasano*dent.tohoku.ac.jp (Please change * to @.)