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Advanced Prosthetic Dentistry


At the Division of Advanced Prosthetic Dentistry, we are involved in various studies aimed at the restoration of form and function after the partial loss of teeth, alveolar process and jawbone.

Specifically, we are developing new treatments involving the use of implants, transplants, regenerative techniques and reconstructive techniques in addition to conventional dental prosthetic techniques, and we are actively involved in research based on a long-term strategy geared towards clarifying the background of biological and biomechanical interfaces between prostheses, biomaterials and the living body. We are also working on the development of advanced active-surface dental implants and innovative new prosthetic materials.

In the future, through the proactive clinical application of new treatment techniques and new materials developed as our research progresses, we hope to contribute to an improved quality of life (QOL) for dental patients.

Faculty configuration

  • Keiichi SasakiProf.Keiichi Sasaki

Topics of Research

  • Biomechanical studies on partial denture prosthesis and implant prosthodontics
  • Nuclear medicine and histological studies on bone remodelling due to prosthetic appliances
  • Transplantation, regeneration and reconstruction of maxillofacial region
  • Creation of new biological materials and new interface related to dentistry
  • Long-term prognosis of removable partial dentures and implant dentures

Recent Performance

  1. Sasaki K: Consideration of dental implant treatment based on biomechanics and mechanobiology: Clinical oral implants research 2016; 10.1111/clr.26_12956.
  2. Yoda N, Ogawa T, Gunji Y, Vanegas JR, Kawata T, Sasaki K: Effects of food texture on three-dimensional loads on implants during mastication based on in vivo measurements: Implant Dentistry 25(4) 2016; 515-519.
  3. Tenkumo T, Vanegas Sáenz JR, Takada Y, Takahashi M, Rotan O, Sokolova V, Epple M, Sasaki K: Gene transfection of human mesenchymal stem cells with a nano-hydroxyapatite-collagen scaffold containing DNA-functionalized calcium phosphate nanoparticles: Genes Cells 21(7) 2016; 682-695.
  4. Matsudate Y, Yoda N, Nanba M, Ogawa, T, Sasaki K: Load distribution on abutment tooth, implant and residual ridge with distal-extension implant-supported removable partial denture: Journal of prosthodontic research 60(4) 2016; 282-288.
  5. Zhang Q, Matsui H, Horiuchi H, Liang X, Sasaki K: A-Raf and C-Raf differentially regulate mechanobiological response of osteoblasts to guide mechanical stress-induced differentiation: Biochem Biophys Res Commun.5;476(4) 2016; 438-444.
  6. Long J, Ogawa T, Ito T, Matsuda M, Li W, Yu H, Sasaki K: Effect of bite openings and mandibular protrusion on genioglossus muscle activity in healthy adults with oral appliance: Odontology 2017 (in press)
  7. Wang WQ, Hong G, Han JM, Murata H, Sasaki K: The effect of crude drugs on the angiogenic property and dynamic viscoelasticity of PEMA-based soft polymer materials: Dental Materials Journal 2017 (in press)

Laboratory Contacts

E-mail:j-yoshidaya*umin.ac.jp (Please change * to @.)