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Craniofacial Function Engineering


In the field of Craniofacial Function Engineering, we explore regenerative medicine, biological material science and tissue engineering. We study the mechanism of biomineralization in bones and teeth through research at the very boundary between engineering and dentistry. We also research alternatives to autogenous bone grafting, such as new bone regeneration materials and regeneration therapy.

More specifically, basing our research on materials science, chemistry, engineering and biology, we concentrate on the following themes of biomaterial fabrication and tissue regeneration for regeneration of bone defects (including oral and maxillofacial region): . (1)Bone regeneration on the molecular, cellular and tissue levels using octacalcium phosphate (OCP). (2)Mechanical stress impact on local control on the cellular and tissue level. (3)Development of new methods for drug delivery for bone disease treatment and bone regeneration. In regards to OCP research, we were devised the world's first stable method of OCP synthesis and were the first to discover bone regeneration ability of OCP (Suzuki O et al. Tohoku J Exp Med 164:37-50, 1991). As a field leading the world in pioneering bone regeneration research, we shall continue to do everything we can to improve the present state of medical treatment.

Faculty configuration

  • Osamu SuzukiProf.Osamu Suzuki

Topics of Research

  • Bone regeneration using self-organising octacalcium phosphate (OCP) to hydroxyapatite.
  • Surface topographic design of metal implants to yield higher mechanical adaptability and bone regenerative capacity.
  • Basic research on calcification regulatory factors and bone regeneration using biological and synthetic polymer carriers applying biomineralization.
  • Investigating osteoblasts and myoblasts based on micro and nano manipulation in cell culture techniques from a tissue engineering viewpoint.
  • Development of new drug and gene delivery methods using synthetic calcium phosphate and the application of these methods to bone regeneration treatment.

Recent Performance

  1. K Kobayashi, T Anada, T Handa, N Kanda, M Yoshinari, T Takahashi, O Suzuki. (2014) Osteoconductive property of a mechanical mixture of octacalcium phosphate and amorphous calcium phosphate. ACS Applied Materials & Interfaces, 6 (24): 22602-22611
  2. K Suzuki, T Anada, T Miyazaki, N Miyatake, Y Honda, K N Kishimoto, M Hosaka, H Imaizumi, E Itoi, O Suzuki. (2014) Effect of addition of hyaluronic acids on osteoconductivity and biodegradability of synthetic octacalcium phosphate. Acta Biomater, 10(1):531-543.
  3. T Kawai, S Echigo, K Matsui, Y Tanuma, T Takahashi, O Suzuki, S Kamakura. (2014) First clinical application of octacalcium phosphate collagen composite in human bone defect Tissue Eng Part A, 20:1336-1341
  4. T Anada, J Fukuda, Y Sai, O Suzuki. (2012) An oxygen-permeable spheroid culture system for the prevention of central hypoxia and necrosis of spheroids. Biomaterials 33: 8430-8441
  5. Y Shiwaku, T Anada, H Yamazaki, Y Honda, S Morimoto, K Sasaki, O Suzuki. (2012) Structural, morphological and surface characteristics of two types of octacalcium phosphate-derived fluoride-containing apatitic calcium phosphates. Acta Biomater 8:4417-4425

Laboratory Contacts

E-mail:suzuki-o*m.tohoku.ac.jp (Please change * to @.)