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Advanced Biofunctional Materials


When it comes to material composition equipment for substitution or reconstruction of biological hard tissues, the most important characteristics are safety in and reliability. Particularly with materials for heavier implants such as artificial joints, bone plates, artificial tooth roots, and blood vessel stents, special metallic materials are chosen with safety and reliability in mind. These biomedical metallic materials obviously require excellent mechanical properties and corrosion resistance, but they also require mechanical and physical chemical characteristics that allow them to work in harmony with body tissues, such as a bone-like low modulus of elasticity (10~30 GPa) or formation of bone constituents (i.e., hydroxyapatite).

In the field of advanced biofunctional materials, we conduct both foundational and practical research to invent metallic materials which combine all of the various characteristics required for use in biomedicine.

Faculty configuration

  • Masaaki NakaiAssociate Prof.
    Masaaki Nakai

Topics of Research

  • Design and Development of New Biomedical Metallic Materials That Work in Harmony with the Body Tissues
  • Prototyping of Biomedical Devices Made of Metallic Materials and Evaluation of Their Efficiency Both Outside and Inside of the Body
  • Strengthening and prolonging Lifespan and Texture Control of Biomedical Metallic Materials through Thermomechanical Treatment
  • Addition of Specific Physical Properties to Biological Metal Materials through Strong Processing Treatment
  • Adaption of Biological Metal Materials to Hard and Soft Tissues through Surface Modification

Recent Performance

  1. Mechanical properties and cytocompatibility of oxygen-modified β-type Ti-Cr alloys for spinal fixation devices, Huihong Liu, Mitsuo Niinomi, Masaaki Nakai, Ken Cho, Kengo Narita, Mustafa Şen, Hitoshi Shiku and Tomokazu Matsue, Acta Biomaterialia, 12(2015), pp. 352-361, doi: 10.1016/j.actbio.2014.10.014.
  2. Predominant factor determining wear properties of β-type and (α+β)-type titanium alloys in metal-to-metal contact for biomedical applications, Yoon-Seok Lee, Mitsuo Niinomi, Masaaki Nakai, Kengo Narita, Junko Hieda and Ken Cho, Journal of the Mechanical Behavior of Biomedical Materials, 41(2015), pp. 208-220, doi: 10.1016/j.jmbbm.2014.10.005.
  3. Changeable Young’s Modulus with Large Elongation-to-failure in β-type Titanium Alloys for Spinal Fixation Applications, Huihong Liu, Mitsuo Niinomi, Masaaki Nakai, Junko Hieda and Ken Cho, Scripta Materialia, 82(2014)pp. 29-32, doi: 10.1016/j.scriptamat.2014.03.014.
  4. Microstructural Evolution of Precipitation-hardened β-type Titanium Alloy through High-pressure Torsion, H. Yilmazer, M. Niinomi, K. Cho, M. Nakai, J. Hieda, S. Sato and Y. Todaka, Acta Materialia, 80(2014), pp. 172-182, doi: 10.1016/j.actamat.2014.07.041.
  5. Deformation-induced Changeable Young’s Modulus with High Strength in β-type Ti-Cr-O Alloys for Spinal Fixture, Huihong Liu, Mitsuo Niinomi, Masaaki Nakai, Junko Hieda and Ken Cho, Journal of the Mechanical Behavior of Biomedical Materials (JMBBM), 30(2014), pp. 205-213, doi: 10.1016/j.jmbbm.2013.11.001.

Laboratory Contacts

E-mail: wbiomat*imr.tohoku.ac.jp (Please change * to @.)
TEL: 81-22-215-2372
FAX: 81-22-215-2553