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Advanced Biocompatible Materials


We are conducting research on the development of new biocompatible materials, physical-chemical surface structure processing techniques to promote integration to tissue, and artificial hybrid tissues, in order to construct human tissue.

We adjust the microstructure of metallic biomaterials through thermomechanical treatment to meet the strength and ductility required for their effective use. However, due to the fact that passive film forms on metallic materials when inside the body, it is necessary to enhance tissue integration through bioceramic coating in order to preserve their bulk characteristic. Utilizing physical vapor deposition (PVD) and chemical vapor deposition (CVD) we coat various metallic materials with bioceramic coating and perform tests on them both inside and outside the body to eventually design ideal high-performance interface for metal/ceramics.

Faculty configuration

  • Takashi GotoProf.Takashi Goto

Topics of Research

  • Synthesis of biocompatible membrane through physical and chemical vapor deposition
  • Microstructure control of biocompatible membrane utilizing plasma and lasers
  • Development of cellular adhesiveness and tissue integration enhancing surface texture processing techniques of titanium and hydroxyapatite
  • Development of artificial hybrid tissue exhibiting superior cell affinity, adhesiveness, water retentivity, heat-retaining properties and workability
  • Development of self-organizing displaceable biocompatible materials exhibiting superior strength, elasticity and water retentivity

Recent Performance

  1. T. Goto, T. Narushima, K. Ueda: Bioceramic Coating on Titanium by Physical and Chemical Vapor Deposition, "BIOMLOGICAL and BIOMEDICAL COATINGS HANDBOOK - Processing and Characterization, Volume 1: Processing and Characterization", 2010, CRC Press, pp. 299-332.
  2. S. Nath, R. Tu, T. Goto: Apatite formation in Hanks' solutionon β-Ca2SiO4 films prepared by MOCVD, Surface & Coatings Technology, 206 [1] (2011) 172-177.
  3. S. Nath, R. Tu, T. Goto: Preparation of Ca-Si-O films by chemical vapor deposition, Surface & Coatings Technology, 205[7] (2010) 2618-2623.
  4. Y. Orii, H. Masumoto, Y. Honda, T. Anada, T. Goto, K. Sasaki, O. Suzuki: Enhancement of octacalcium phosphate deposition on a titanium surface activated by electron cyclotron resonance plasma oxidation, Journal of Biomedical Materials Research Part B: Applied Biomaterials, 93B[2] (2010) 476-483.
  5. M. Sato, R. Tu, T. Goto, K. Ueda, T. Narushima: Preparation of Ca-Si-O films Apatite formation behavior on bio-ceramic films prepared by MOCVD, Journal of the Ceramic Society of Japan, 117[4] (2009) 461-465.
  6. M. Sato, R. Tu, T. Goto, K. Ueda, T. Narushima: Preparation behavior in a Hanks' solution on Ca-P-O films prepared by laser CVD, Materials Transactions, 50[10] (2009) 2455-2459.
  7. Z.-K. Kim, J.-J. Oak, H. Kimudra, T. Goto, A. Inoue, S.-Y. Yoon: Achitecture of porous hydroxyapatite scaffolds using polymer foam process, Journal of Biomechanical Science and Engineering, 4[3] (2009) 377-383.

Laboratory Contacts

E-mail: goto*imr.tohoku.ac.jp (Please change * to @.)