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Intractable Diseases and Immunology

Introduction

In clinical medicine, immunology is an indispensable field. For example, anaphylactic shock by anesthesia, and infections by invasive treatment are major problems in the field of dentistry. In addition, to treat the patients bearing any systemic diseases, immunology is quite helpful. Furthermore, since many intractable diseases often first appear as lesions in the oral cavity, dentists with excellent knowledge of immunology are able to discover serious diseases.

In our laboratory, we conduct research on NK cells which work the forefront of immune system and we are investigating the NK cell function and roles of their receptors to understand pathogenesis of infections, tumors, autoimmune diseases (diabetes and intractable diseases), transplant rejection and allergies (metal, food, pollen). Studies on NK cells and their receptors are an attracting field in worldwide. We actively promote joint research with the world's top scientists, aiming at breakthrough. Interacting with various people from diverse fields is another appealing point of our laboratory. In our laboratory, researchers are composed of the Faculty of Medicine, Engineering, Dentistry, Pharmacy and Science. These researchers often join us and work together with us. We welcome and are hoping to share the excitement and thrill of our research with many students interested in the field.

Faculty configuration

  • kouetsu OgasawaraProf.kouetsu Ogasawara

Topics of Research

  • To explore how tumors escape from immune system
  • To examine the target recognition mechanism of NK cells
  • To explore the molecular mechanism of "dressed cells"
  • Understanding the molecular mechanism of the onset of autoimmune diseases and developing their treatment
  • Development of new methods for diagnosis and treatment of metal allergies

Recent Performance

  1. Nakayama M, Takeda K, Kawano M, Takai T, Ishii N, Ogasawara K. (2011) NK-dendritic cell interactions generate MHC class II-dressed NK cells that regulate CD4+ T cells. Proc Natl Acad Sci U S A. 108 (45):18360-18365
  2. Takeda K, Nakayama M, Sakaki M, Hayakawa Y, Imawari M, Ogasawara K, Okumura K, Smyth MJ. IFN-γ production by lung NK cells is critical for the natural resistance to pulmonary metastasis of B16 melanoma in mice. (2011) Journal of Leukocyte Biology 90(4):777-85.
  3. Honda T, Nakajima S, Egawa G, Ogasawara K, Malissen B, Miyachi Y, Kabashima K.(2010) Compensatory role of Langerhans cells and langerin-positive dermal dendritic cells in the sensitization phase of murine contact hypersensitivity J Allergy Clin Immunol 125(5):1154-1156.e2.
  4. Vilarinho S, Ogasawara K, Nishimura S, Lanier LL, Baron JL. (2007) Blockade of NKG2D on NKT cells prevents hepatitis and the acute immune response to hepatitis B virus. Proc Natl Acad Sci U S A. 104(46):18187-92.
  5. Ogasawara K, Benjamin J, Takaki R, Phillips J H, Lanier L L. (2005) Function of NKG2D in natural killer cell-mediated rejection of mouse bone marrow grafts. Nature Immunology 6(9):938-945.

Laboratory Contacts

E-mail:imbio1*idac.tohoku.ac.jp (Please change * to @.)
TEL:81-22-717-8579
FAX:81-22-717-8452

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