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Orthodontics and Dentofacial Orthopaedics


The department of Orthodontics and Dentofacial Orthopedics mainly focus on a basic research and treatment of malocclusion, cleft lip palate, congenital diseases, and orthognathic surgery cases.

In the recent years, remarkable progress occurred in the field of orthodontics with the advancement of technology and introduction of new biomedical materials. Clinical research topics in our department includes clinical evaluation of treatment effects usinfg miniscrews as orthodontic anchorage, the use of functional evaluation, treatment of sleep apnea syndrome, and creative clinical research of relationship between the facial aesthetics and brain functions. As for projects with a biological related studies, mechanisms of tooth movement and mechanical response in chondrocyted and osteocytes, stem cell differentiation and regeneration of tooth derived tissue, and regeneration of tooth bioengineered tooth germ are the main topics in our department. Our aim is to provide contributions to the development of safe and high quality medical care by merging the latest treatment technology and scientific findings into our current treatment.

In addition, we have established an advanced treatment techniques and a pioneer in developing and using miniscrews as orthodontic anchorage and orthpedic correction that is widely accepted among orthodontists all around the world. Many cases are treated by using lingual appliance that requires advanced technique in our clinic. We have been published numerous international journals, invited as international speaker, presented in many meetings and received many awards that contributes providing important information to other orthodontists.

Faculty configuration

  • Itaru MizoguchiProf. Itaru Mizoguchi
  • Hideki KitauraAssociate Prof.
    Hideki Kitaura

Topics of Research

  • Development of orthodontic treatment using orthodontic anchor screws.
  • Development of 3D simulation system for surgical orthodontic treatment.
  • Research in process of bone deformation by mechanical stress.
  • Histological and molecular biological study of periodontal cells and bone cells.
  • Basic study on development of artificial tooth germ.
  • Analysis of osteoclast differentiation and activation mechanisms and identification of inhibitory factor of pathological bone resorption.
  • Clarification about regulatory mechanisms of endochondral bone formation.
  • Clarification about effects of joint loading on expression of matrix components in TMJ.

Recent Performance

  1. Ida H, Seiryu M, Takeshita N, Iwasaki M, Yokoyama Y, Tsutsumi Y, Ikeda E, Sasaki S, Miyashita S, Sasaki S, Fukunaga T, Deguchi T, Takano-Yamamoto T. Biosafety, stability, and osteogenic activity of novel implants made of Zr70Ni16Cu6Al8 bulk metallic glass for biomedical application. Acta Biomater 74:505–517, 2018.
  2. Sugisawa H, Kitaura H, Ueda K, Kimura K, Ishida M, Ochi Y, Kishikawa A, Ogawa S, Takano-Yamamoto T. Corrosion resistance and mechanical properties of titanium nitride plating on orthodontic wires. Dent Mater J 37(2):286–292, 2018.
  3. Matsuzawa H, Toriya N, Nakao Y, Konno-Nagasaka M, Arakawa T, Okayama M, Mizoguchi I. Cementocyte cell death occurs in rat cellular cementum during orthodontic tooth movement. Angle Orthod 87(3):416–422, 2018.
  4. Takano-Yamamoto T, Sasaki K, Fatemeh G, Fukunaga T, Seiryu M, Daimaruya T, Takeshita N, Kamioka H, Adachi T, Ida H, Mayama A. Synergistic acceleration of experimental tooth movement by supplementary high-frequency vibration applied with a static force in rats. Sci Rep 7(1):13969, 2017.
  5. Bando K, Tanaka Y, Kuroishi T, Sasaki K, Takano-Yamamoto T, Sugawara S, Endo Y. Mouse model of hydroquinone hypersensitivity via innate and acquired immunity and its promotion by combined reagents. J Invest Dermatol 137(5):1082–1093, 2017.
  6. Shima K, Tsuchiya M, Oizumi T, Takano-Yamamoto T, Sugawara S, Endo Y. Inflammatory Effects of nitrogen-containing bisphosphonates (N-BPs): Modulation by non-N-BPs. Biol Pharm Bull 40(1):25-33, 2017.
  7. Takano-Yamamoto T, Fukunaga T, Takeshita N. Gene expression analysis of CCN protein in bone under mechanical stress. Methods Mol Biol 1489:283–308, 2017.
  8. Takeshita N, Hasegawa M, Sasaki K, Seki D, Seiryu M, Miyashita S, Takano I, Oyanagi T, Miyajima Y, Takano-Yamamoto T. In vivo expression and regulation of genes associated with vascularization during early response of sutures to tensile force. J Bone Miner Metab 35(1):40–51, 2017.
  9. Saeed J, Kitaura H, Kimura K, Ishida M, Sugisawa H, Ochi Y, Kishikawa A, Takano-Yamamoto T. IL-37 inhibits lipopolysaccharide-induced osteoclast formation and bone resorption in vivo. Immunol Lett 175: 8–15, 2016.
  10. Shima K, Nemoto W, Tsuchiya M, Tan-No K, Takano-Yamamoto T, Sugawara S, Endo Y. The bisphosphonates clodronate and etidronate exert analgesic effects by acting on glutamate- and/or ATP-related pain transmission pathways. Biol Pharm Bull 39(5):770–777, 2016.
  11. Kinbara M, Bando K, Shiraishi D, Kuroishi T, Nagai Y, Ohtsu H, Takano-Yamamoto T, Sugawara S, Endo Y. Mast cell histamine-mediated transient inflammation following exposure to nickel promotes nickel allergy in mice. Exp Dermatol 25(6):466–471, 2016.
  12. Yoshida M, Hata K, Takashima R, Ono K., Nakamura E, Takahata Y, Murakami T, Iseki S, Takano-Yamamoto T, Nishmura R, Yoneda T. The transcription factor Foxc1 is necessary for Ihh-Gli2-regulated endochondral ossification. Nat Commun 26(6):6653, 2015.
  13. Ishida M, Kitaura H, Kimura K, Sugisawa H, Aonuma T, Takada H, Takano-Yamamoto T. Muramyl dipeptide enhances lipopolysaccharide-induced osteoclast formation and bone resorption through increased RANKL expression in stromal cells. J Immunol Res (Clin Dev Immunol), Article ID 132765, 12 pages, 2015.
  14. Hakami ZW, Kitaura H, Kimura K, Ishida M, Sugisawa H, Ida H, Takano-Yamamoto T. Effect of Interleukin-4 on orthodontic tooth movement and associated root resorption. Eur J Orthod 37(1):87–94, 2015.
  15. Deguchi T, Seiryu M, Daimaruya T, Garetto LP, Takano-Yamamoto T, Roberts WE. Decreased alveolar bone turnover is related to the occurrence of root resorption during experimental tooth movement in dogs. Angle Orthod 85(3):386–393, 2015.
  16. Nakao Y, Konno-Nagasaka M, Toriya N, Arakawa T, Kashio H, Takuma T, Mizoguchi I. Proteoglycan expression is influenced by mechanical load in TMJ discs. J Dent Res 94(1):93–100, 2015.
  17. Hoshi K, Kawaki H, Takahashi I, Takeshita N, Seiryu M, Murshid SA, Masuda T, Anada T, Kato R, Kitaura H, Suzuki O, Takano-Yamamoto T. Compressive force-produced CCN2 induces osteocyte apoptosis through ERK1/2 pathway. J Bone Miner Res 29(5):1244–1257, 2014.
  18. Hosoya H, Kitaura H, Hashimoto T, Ito M, Kinbara M, Deguchi T, Irokawa T, Ohisa T, Ogawa H, Takano-Yamamoto T. Relationship between sleep bruxism and sleep respiratory events in patients with obstructive sleep apnea syndrome. Sleep Breath 18(4):837–844, 2014.
  19. Kimura K, Kitaura H, Fujii T, Ishida M, Hakami ZW, Takano-Yamamoto T. An anti-c-Fms antibody inhibits osteoclastogenesis in a mouse periodontitis model. Oral Dis 20(3):319–324, 2014.
  20. Bando K, Takahashi H, Kinbara M, Tanaka Y, Kuroishi T, Sasaki K, Takano-Yamamoto T, Sugawara S, Endo Y. Resin monomers act as adjuvants in Ni-induced allergic dermatitis in vivo. J Dent Res 93(11):1101–1107, 2014.
  21. Kitaura H, Kimura K, Ishida M, Sugisawa H, Kohara H, Yoshimatsu M, Takano-Yamamoto T. Effect of cytokines on osteoclast formation and bone resorption during mechanical force loading of the periodontal membrane. Sci World J 617032, 2014.

Laboratory Contacts

E-mail:mizo*tohoku.ac.jp (Please change * to @.)