HOME > Guide of course > Immune Regulation and Oral Immunity

Immune Regulation and Oral Immunity

Introduction

The oral mucosa is a front line of host defense system against microbes and hazardous antigens. It also becomes targets of inflammation caused by autoimmune or allergic responses. Immune regulation of oral immunity is critical issue to control infections and keep Quality of Life (QOL) of disease patients.We are investigating, 1) Signal transduction and regulation by microenvironments operating in the host defense system, 2) Mechanisms for the production of autoantibodies involved in the disease development and maintenance of autoimmune disorders including Sjögren syndrome, 3) Regulations for the maintenance and expansion of tissue stem cells, to manipulate and regulate immune responses in oral mucosa.

Faculty configuration

  • Visiting Prof.
    Satoshi Takaki

Topics of Research

  • Signal transduction and regulation in humoral immune responses.
  • Mechanisms for the generation and function of auto-antibodies involved in various autoimmune diseases.
  • Development of methods for manipulating or reconstituting the immune system.

Recent Performance

  1. Katayama H, Mori T, Seki Y, Anraku M, Iseki M, Ikutani M, Iwasaki Y, Yoshida N, Takatsu K, Takaki S. Lnk prevents inflammatory CD8+ T-cell proliferation and contributes to intestinal homeostasis. Eur J Immunol. 2014 Feb 17. doi: 10.1002/eji.201343883.
  2. Nishimura S, Manabe I, Takaki S, Nagasaki M, Otsu M, Yamashita H, Sugita J, Yoshimura K, Eto K, Komuro I, Kadowaki T, Nagai R. Adipose natural regulatory B cells negatively control adipose tissue inflammation. Cell Metabolism. 2013; 18:759-66.
  3. Ikutani M, Yanagibashi T, Ogasawara M, Tsuneyama K, Yamamoto S, Hattori Y, Kouro T, Itakura A, Nagai Y, Takaki S*, Takatsu K*. [*co-corresponding authors] Identification of innate IL-5-producing cells and their role in lung eosinophil regulation and antitumor immunity. J Immunol. 2012; 188: 703-13.
  4. Suzuki N, Yamazaki S, Ema H, Yamaguchi T, Nakauchi H, Takaki S. Homeostasis of hematopoietic stem cells regulated by the myeloproliferative disease associated-gene product Lnk/Sh2b3 via Bcl-xL. Exp Hematol. 2012; 40: 166-174.e3.
  5. Takizawa H, Nishimura S, Takayama N, Oda A, Nishikii H, Morita Y, Kakinuma S, Yamazaki S, Okamura S, Tamura N, Goto S, Sawaguchi A, Manabe I, Takatsu K, Nakauchi H, Takaki S*, Eto K*. [*co-corresponding authors] Lnk/Sh2b3 regulates integrin αIIbβ3 outside-in signaling in platelets leading to stabilization of developing thrombus in vivo. J Clin Invest. 2010;120: 179-90.

Laboratory Contacts

E-mail:lbstakaki*hospk.ncgm.go.jp (Please change * to @.)
TEL:81-47-375-4747
FAX:81-47-375-4761

Pagetop