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Oral Molecular Bioregulation


It is rare for diseases of the mouth (oral diseases) to produce life-threatening symptoms. However, oral diseases do cause a considerable drop in quality of life (QOL). Additionally, it is characteristic for systemic diseases to produce symptoms in the mouth and for oral diseases to produce symptoms throughout the body. Our laboratory works day and night to use immunology, molecular biology, and pharmacology to uncover the "mysteries" of these diseases. We then use this foundational research to take the first steps toward developing safe and effective prevention and treatment methods.

Our laboratory is composed not only of graduates from the school of dentistry but a staff of diverse backgrounds to seriously wrestle with our research. We openly welcome graduate students with an interest in the "mysteries" of life science, including those in dentistry. We are accepting many graduate students from clinical fields aspiring towards foundational research.

Faculty configuration

  • Prof.Shunji SugawaraProf.Shunji Sugawara

Topics of Research

  • Immunoregulation in the Oral Mucosa
  • Mechanism of Metal Allergy Development
  • Molecular Mechanism of Salivary Gland Diseases
  • Regulation of Inflammation by Biotin
  • Immunological and Physiological Functions of Histamine
  • Role of chronic allergic inflammation in oral infectious diseases
  • Role of epithelial barrier dysfunction in oral infectious diseases
  • Regulation of oral mucosal homeostasis by oral commensal bacteria
  • Innate immune responses of bacterial cellular components

Recent Performance

  1. Kuroishi T, Band, K, Tanaka Y, Shishido K, Kinbara M, Ogawa T, Muramoto K, Endo Y, Sugawara S. CXCL4 is a novel nickel-binding protein and augments nickel allergy. Clin. Exp. Allergy in press.
  2. Lu L, Tanaka Y, Ishii N, Sasano T, Sugawara S. CD103+CD11b− salivary gland dendritic cells have antigen cross-presenting capacity. Eur. J. Immunol. 47 (2): 305-313, 2017.
  3. Tanaka Y, Nagashima H, Bando K, Lu L, Ozaki A, Morita Y, Fukumoto S, Ishii N, Sugawara S. Oral CD103−CD11b+ classical dendritic cells present sublingual antigen and induce Foxp3+ regulatory T cells in draining lymph nodes. Mucosal Immunol. 10 (1): 79-90, 2017.
  4. Tada H, Matsuyama T, Nishioka T, Hagiwara M, Kiyoura Y, Shimauchi H, Matsushita K. Porphyromonas gingivalis gingipain-dependently enhances IL-33 production in human gingival epithelial cells. PLOS ONE, 11(4): e0152794. 2016.
  5. Nagai Y, Shiraishi D, Tanaka Y, Nagasawa Y, Ohwada S, Shimauchi H, Aso H, Endo Y, Sugawara S. Transportation of sublingual antigens across sublingual ductal epithelial cells to the ductal antigen-presenting cells in mice. Clin. Exp. Allergy 45 (3): 677-686, 2015.

Laboratory Contacts

E-mail:oral_immunology*dent.tohoku.ac.jp (Please change * to @.)