Ecological DentistryPeriodontology and Endodontology
We focus on two major infectious oral diseases, periodontal diseases and endodontic diseases (pulp and apical periodontal tissue diseases). We are studying a mechanism of the onset and development of these chronic inflammatory diseases, and developing regenerative treatment for periodontal tissue and the pulp-dental complex.
In the recent years, it has been made clear that oral bacterial infections such as periodontal diseases can affect the systemic health. We try not only to develop effective diagnosis and treatment methods based on the onset mechanisms of these diseases, but also to research the regenerative medicine of periodontal tissue, which consists of soft and hard tissues, and the pulp-dentin complex. Our accomplishments so far have been reported in many prestigious international journals of not only dentistry but also of basic medical sciences.
We are responsible for the Departments of Periodontology and Endodontology at the Tohoku University Hospital Dental Division. We perform not only conduct clinical research and practice clinical trials, but also advanced medical treatment of periodontal and endodontic diseases. Our goal is establishing systemic health through oral health.
Staff
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Prof. Satoru Yamada,
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Associate Prof. Eiji Nemoto,
Topics of Research
- Molecular and Cellular Pathogenesis of Periodontal and Periapical Diseases
- Molecular Pathogenesis of Periodontal-Systemic Link
- Periodontal Regenerative Medicine
- Development of Diagnostic Strategies of Periodontal Disease
- Development of precise micro fabrication technology for producing biomaterials
- Pathophysiology of the Dental Pulp and Periodontium
Recent Publications
- Epigenetics in susceptibility, progression, and diagnosis of periodontitis. Shigeki Suzuki, Satoru Yamada. The Japanese dental science review 58 183-192 2022.
- Loss of IκBζ drives dentin formation via altered H3K4me3 status H. Yuan, S. Suzuki, H. Terui, S. Hirata-Tsuchiya, E. Nemoto, K. Yamasaki, M. Saito, H. Shiba, S. Aiba, S. Yamada. Journal of Dental Research 101(8) 951-961 2022.
- Extracellular vesicles derived from murine cementoblasts possess the potential to increase receptor activator of Nuclear Factor-κB Ligand-induced osteoclastogenesis. Rei Sato, Kentaro Maruyama, Eiji Nemoto, Yukihiko Sakisaka, Shigeki Suzuki, Jiajun Li, Kento Numazaki, Hiroyuki Tada, Satoru Yamada. Frontiers in physiology 13 825596-825596 2022.
- Porphyromonas gingivalis induces entero-hepatic metabolic derangements with alteration of gut microbiota in a type 2 diabetes mouse model. Yoichiro Kashiwagi, Shunsuke Aburaya, Naoyuki Sugiyama, Yuki Narukawa, Yuta Sakamoto, Masatomo Takahashi, Hayato Uemura, Rentaro Yamashita, Shotaro Tominaga, Satoko Hayashi, Takenori Nozaki, Satoru Yamada, Yoshihiro Izumi, Atsunori Kashiwagi, Takeshi Bamba, Yasushi Ishihama, Shinya Murakami. Scientific reports 11(1) 18398-18398 2021.
- PPARγ-induced global H3K27 acetylation maintains osteo/cementogenic abilities of periodontal ligament fibroblasts. Hang Yuan, Shigeki Suzuki, Shizu Hirata-Tsuchiya, Akiko Sato, Eiji Nemoto, Masahiro Saito, Hideki Shiba, Satoru Yamada. International journal of molecular sciences 22(16) 2021.
- Mouse model of Loeys-Dietz syndrome shows elevated susceptibility to periodontitis via alterations in Transforming Growth Factor-Beta signaling. Satoru Yamada, Kenichiro Tsushima, Masaki Kinoshita, Hiromi Sakashita, Tetsuhiro Kajikawa, Chiharu Fujihara, Hang Yuan, Shigeki Suzuki, Takayuki Morisaki, Shinya Murakami. Frontiers in physiology 12 715687-715687 2021.
- DMP-1 promoter-associated antisense strand non-coding RNA, panRNA-DMP-1, physically associates with EGFR to repress EGF-induced squamous cell carcinoma migration. Shigeki Suzuki, Hang Yuan, Shizu Hirata-Tsuchiya, Kazuma Yoshida, Akiko Sato, Eiji Nemoto, Hideki Shiba, Satoru Yamada. Molecular and cellular biochemistry 476(4) 1673-1690 2021.
- Mice lacking PLAP-1/asporin counteracts high fat diet-induced metabolic disorder and alveolar bone loss by controlling adipose tissue expansion. Hiromi Sakashita, Satoru Yamada, Masaki Kinoshita, Tetsuhiro Kajikawa, Tomoaki Iwayama, Shinya Murakami. Scientific reports 11(1) 4970-4970 2021.
- Expression of asporin reprograms cancer cells to acquire resistance to oxidative stress. Yuto Sasaki, Kurara Takagane, Takumi Konno, Go Itoh, Sei Kuriyama, Kazuyoshi Yanagihara, Masakazu Yashiro, Satoru Yamada, Shinya Murakami, Masamitsu TanakaCancer science 112(3) 1251-1261 2021.
- Inhibition of the CXCL9-CXCR3 axis suppresses the progression of experimental apical periodontitis by blocking macrophage migration and activation. Tatsuya Hasegawa, V Venkata Suresh, Yoshio Yahata, Masato Nakano, Shigeto Suzuki, Shigeki Suzuki, Satoru Yamada, Hideki Kitaura, Itaru Mizoguchi, Yuichiro Noiri, Keisuke Handa, Masahiro Saito. Scientific reports 11(1) 2613-2613 2021.
- A large-scale observational study to investigate the current status of diabetic complications and their prevention in Japan (JDCP study 6): baseline dental and oral findings. Koji Inagaki, Takeshi Kikuchi, Toshihide Noguchi, Akio Mitani, Keiko Naruse, Tatsuaki Matsubara, Masamitsu Kawanami, Jun Negishi, Yasushi Furuichi, Eiji Nemoto, Satoru Yamada, Hiromasa Yoshie, Koichi Tabeta, Sachiyo Tomita, Atsushi Saito, Sayaka Katagiri, Yuichi Izumi, Hiroshi Nitta, Takanori Iwata, Yukihiro Numabe, Matsuo Yamamoto, Nobuo Yoshinari, Tsuyoshi Fujita, Hidemi Kurihara, Fusanori Nishimura, Toshihiko Nagata, Hiromichi Yumoto, Toru Naito, Kazuyuki Noguchi, Koichi Ito, Shinya Murakami, Rimei Nishimura, Naoko Tajima. Diabetology international 12(1) 52-61 2021.
- Guidelines for innovation in dental education during the coronavirus disease 2019 pandemic. Guang Hong, Tsai-Yu Chang, Andrew Terry, Supachai Chuenjitwongsa, Young-Seok Park, James K Tsoi, M F Lindawati S Kusdhany, Hiroshi Egusa, Satoru Yamada, Jae-Sung Kwon, Liang-Lin Seow, Ma Cristina A G Garcia, Mun-Loke Wong, Prim Auychai, Ming-Lun Hsu. Journal of oral science 63(1) 107-110 2020.
- Evaluation of preosteoblast MC3T3-E1 cells cultured on a microporous titanium membrane fabricated using a precise mechanical punching process. Jingyu Zhang, Yukihiko Sakisaka, Hiroshi Ishihata, Kentaro Maruyama, Eiji Nemoto, Shigeki Chiba, Masaru Nagamine, Hiroshi Hasegawa, Satoru Yamada. Materials (Basel, Switzerland) 13(22) 1-15 2020.
- A small nuclear acidic protein (MTI-II, Zn2+-binding protein, parathymosin) attenuates TNF-α inhibition of BMP-induced osteogenesis by enhancing accessibility of the Smad4-NF-κB p65 complex to Smad binding element. Hirata-Tsuchiya S, Suzuki S, Okamoto K, Saito N, Yuan H, Yamada S, Jimi E, Shiba H, Kitamura C. Molecular and Cellular Biochemistry 469(1-2) 133-142 2020.
- Dentin phosphoprotein inhibits lipopolysaccharide-induced macrophage activation independent of its serine/aspartic acid-rich repeats. Nakanishi J, Suzuki S, Yoshida K, Hirata-Tsuchiya S, Haruyama N, Yamada S, Shiba H. Archives of Oral Biology 110 104634-104634 2020.
- Mechanical regulation of macrophage function - cyclic tensile force inhibits NLRP3 inflammasome-dependent IL-1β secretion in murine macrophages. Maruyama K, Nemoto E, Yamada S. Inflammation and Regeneration 39(1) 3-3 2019.
- Heparin–LL37 complexes are less cytotoxic for human dental pulp cells and have undiminished antimicrobial and LPS-neutralizing abilities. Yoshida K, Suzuki S, Kawada-Matsuo M, Nakanishi J, Hirata-Tsuchiya S, Komatsuzawa H, Yamada S, Shiba H. International Endodontic Journal 52(9) 1327-1343 2019.
- Cyclic Stretch force induces periodontal ligament cells to secrete exosomes that Suppress IL-1β production through the inhibition of the NF-κB signaling pathway in macrophages. Wang Z, Maruyama K, Sakisaka Y, Suzuki S, Tada H, Suto M, Saito M, Yamada S, Nemoto E. Frontiers in Immunology 10 1310-1310 2019.
- Cyclic stretch negatively regulates IL-1β secretion through the inhibition of NLRP3 inflammasome activation by attenuating the AMP kinase pathway. Maruyama K, Sakisaka Y, Suto M, Tada H, Nakamura T, Yamada S, Nemoto E. Frontiers in Physiology 9 802 2018.