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Periodontology and Endodontology


We focus on two major infectious oral diseases, periodontal diseases and endodontic diseases (pulp and apical periodontal tissue diseases). We are studying a mechanism of the onset and development of these chronic inflammatory diseases, and developing regenerative treatment for periodontal tissue and the pulp-dental complex.

In the recent years, it has been made clear that oral bacterial infections such as periodontal diseases can affect the systemic health. We try not only to develop effective diagnosis and treatment methods based on the onset mechanisms of these diseases, but also to research the regenerative medicine of periodontal tissue, which consists of soft and hard tissues, and the pulp-dentin complex. Our accomplishments so far have been reported in many prestigious international journals of not only dentistry but also of basic medical sciences.

We are responsible for the Departments of Periodontology and Endodontology at the Tohoku University Hospital Dental Division. We perform not only conduct clinical research and practice clinical trials, but also advanced medical treatment of periodontal and endodontic diseases. Our goal is establishing systemic health through oral health.

Faculty configuration

  • Prof.Satoru YamadaProf.Satoru Yamada
  • Associate Prof.Eiji NemotoAssociate Prof.
    Eiji Nemoto

Topics of Research

  • Molecular and Cellular Pathogenesis of Periodontal and Periapical Diseases
  • Molecular Pathogenesis of Periodontal-Systemic Link
  • Periodontal Regenerative Medicine
  • Development of Diagnostic Strategies of Periodontal Disease
  • Development of precise micro fabrication technology for producing biomaterials
  • Pathophysiology of the Dental Pulp and Periodontium

Recent Performance

  1. Tada H, Nemoto E, Foster BL, Somerman MJ, Shimauchi H. Phosphate increases bone morphogenetic protein-2 expression through cAMP-dependent protein kinase and ERK1/2 pathways in human dental pulp cells. Bone 48:1409-1416, 2011.
  2. Kanaya S, Nemoto E, Ebe Y, Somerman MJ, Shimauchi H. Elevated extracellular calcium increases fibroblast growth factor-2 gene and protein expression levels via a cAMP/PKA dependent pathway in cementoblasts. Bone 47:564-572, 2010.
  3. Mayanagi G, Kimura M, Nakaya S, Hirata H, Sakamoto M, Benno Y, Shimauchi H. Probiotic effects of orally administered Lactobacillus salivarius WB21-containing tablets on periodontopathic bacteria: a double-blinded, placebo-controlled, randomized clinical trial. Journal of Clinical Periodontology 36:506-513, 2009.
  4. Nemoto E, Koshikawa Y, Kanaya S, Tsuchiya M, Tamura M, Somerman, MJ, Shimauchi H. Wnt signaling inhibits cementoblast differentiation and promotes proliferation. Bone 44:805-812, 2009.
  5. Shimauchi H, Mayanagi G, Nakaya S, Minamibuchi M, Ito Y, Yamaki K, Hirata H. Improvement of periodontal condition by probiotics with Lactobacillus salivarius WB21: a randomized, double-blind, placebo-controlled study. Journal of Clinical Periodontology 35:897-905, 2008.

Laboratory Contacts

E-mail:e-nemoto*dent.tohoku.ac.jp (Please change * to @.)